The Simultaneous Application of Transcranial Magnetic Stimulation and Virtual Reality to Treat Cognitive Deficits Among Stroke Patients: A Randomized Controlled Trial DOI Open Access

Priya Chauhan,

Sanjib K Das,

SD Shahanawaz

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 15, 2024

Background and objective Integrating virtual reality (VR) transcranial magnetic stimulation (TMS) offers a promising strategy for stroke rehabilitation, as it specifically focuses on reorganizing neural connections activating brain activity in the cortex. The main goal is to create equitable between brain's two hemispheres enhance execution of voluntary movements by stimulating central executive network (CEN) strengthen both motor cognitive abilities. This study aims propose therapeutic approach that can improve recovery overall quality life patients after stroke. Methods A total 69 participants were enrolled based certain inclusion exclusion criteria. underwent pre-assessment randomly allocated into three groups: Group 1 received simultaneous repetitive TMS (rTMS) treatment (VRT), 2 rTMS combined with sham VRT, 3 1:1:1 ratio using opaque, sealed, stapled envelopes (SNOSE). Post-assessment was carried out same measures: National Institutes Health Stroke Scale (NIHSS), Addenbrooke's Cognitive Test (ACE III), Montreal Assessment (MOCA). Statistical analysis conducted determine specific outcomes. Data IBM SPSS Statistics version 29 (IBM Corp., Armonk, NY), employing student's t-test within-group comparisons repeated measures ANOVA between-group comparisons. significance level set at 5%. Results results demonstrated statistical NIHSS scores across all groups (p<0.001). Regarding outcomes, improvements observed memory, language, performance III) within (p<0.05), significant outcomes (p = 0.009, p 0.01, 0.004, respectively), suggesting variations effects domains. However, no differences found terms fluency visuospatial skills 0.49, 0.13), indicating these Conclusions Based our findings, intervention involving compared treatments, demonstrates alleviating severity improving functions such performance. Additionally, administration more effective therapy than when they are administered separately.

Language: Английский

Repetitive transcranial magnetic stimulation elevates the serum levels of neurotrophic factors and serotonin and its metabolites in patients with ischemic stroke DOI Creative Commons
Wei Li, Wenyan Li,

Yinghua Wen

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

Repetitive transcranial magnetic stimulation (rTMS) can effectively treat cognitive impairment in stroke patients; however, its mechanism of action remains unclear. The aim this study was to investigate whether rTMS improves function by regulating the levels brain-derived neurotrophic factor (BDNF), nerve growth (NGF), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA). In a 4-week study, 70 patients with ischemic were randomly assigned two groups: one received (n = 35) other sham-stimulation addition conventional medication rehabilitation training. Patients group treated at 10 Hz for 20 min per session. Montreal Cognitive Assessment (MoCA) response time n-back task used assess severity disease. Fasting venous blood collected early morning, both before after treatment. peripheral BDNF, NGF, 5-HT, 5-HIAA measured using enzyme-linked immunosorbent assay (ELISA). BDNF NGF higher than sham (p 0.017, p 0.008), treatment, 5-HT also elevated 0.049, 0.004). changes serum treatment correlated MoCA task. There positive correlation between (r 0.4034). Our results showed that upregulated which likely contributed improvements quality life stroke. https://www.chictr.org.cn/showproj.html?proj=216761, ChiCTR2400082383.

Language: Английский

Citations

0
Therapeutic efficacy of repetitive transcranial magnetic stimulation on gait and limb balance function in patients with lower limb dysfunction post-cerebral infarction: a systematic review and meta-analysis DOI Creative Commons

De-mei Jia,

Xuan Li,

Bin-cang Zhang

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 24, 2025

This investigation is designed to evaluate the effects of rTMS and its varying stimulation parameters target sites on therapeutic outcomes for post-stroke lower limb motor impairment balance, with objective pinpointing locations that are both reasonable applicable in clinical practice. An exhaustive search was carried out across PubMed, MEDLINE, Embase, CENTRAL, Web Science databases identify RCTs assessed effectiveness treatment following a stroke. Meta-analysis performed usingR statistical environment (V.4.2.2, www.r-project.org ). The review period encompassed interval from databases' origination through February 18, 2024. Research reveals applying unaffected cortex markedly enhances gait speed stroke patients,exhibiting significant effect (SMD: 1.117, 95% CI:0.40, 1.82, I2 = 0.0%). sessions comprising 1000–1500 pulses 0.92, CrI:0.63, 1.21, 42%, six studies), total session count ≥ 10 0.85, CrI:0.53, 1.18, 54.1%, high-frequency 0.83, CrI:0.34, 1.09, 46.3%, three studies) exhibit efficacyin improving balance post-stroke. research indicates has been instrumental enhancing prognosis balance. Nevertheless, efficacy subject diversity parameter settings.

Language: Английский

Citations

0
Repetitive Transcranial Magnetic Stimulation for Refractory and Super-refractory Status Epilepticus: A Systematic Review DOI Creative Commons

Chloé Algoet,

Kato Van Rooy,

Paul Boon

et al.

Neuromodulation Technology at the Neural Interface, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Age-defying swallowing DOI Creative Commons

María-Itatí Palacio,

Rafael Abella Bermejo,

Ana-María Lucas-Ochoa

et al.

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: April 7, 2025

Swallowing disorders, which are generally underdiagnosed, affect the elderly, leading to a decreased quality of life and complications, including aspiration pneumonia death. Understanding neurophysiology swallowing causes its dysfunction is fundamental tool for prevention, early diagnosis, treatment dysphagia. New technologies open wide range possibilities implementation new care protocols this disorder.

Language: Английский

Citations

0
Non-invasive brain stimulation lighting the human life quality’s bulb DOI Creative Commons

T. Zhang,

Xiaofeng Jing,

Qiongfang Cao

et al.

Brain-Apparatus Communication A Journal of Bacomics, Journal Year: 2025, Volume and Issue: 4(1)

Published: April 6, 2025

Language: Английский

Citations

0
A new treatment for neuropathic pain: a narrative review of non-invasive magnetic stimulation based on the central nervous system DOI

Chenyuan Zhai,

Jili Cai,

Yan Gong

et al.

Advanced technology in neuroscience ., Journal Year: 2025, Volume and Issue: 2(2), P. 91 - 96

Published: April 8, 2025

Neuropathic pain is a prevalent condition resulting from damage or dysfunction of the central peripheral nervous system. With increasing incidence neuropathic pain, its management has become significant public health concern. This review aims to provide comprehensive mechanisms action and recent research progress related use non-invasive magnetic stimulation system in treatment pain. The secondary pathophysiological changes after lesion disease somatosensory system, including sensitization ion channels, activation immune cells, involvement glial-derived mediators, are underlying that lead persistence Over past 20 years, shown potential for chronic Repetitive transcranial emerged as an effective neuromodulation technique, providing substantial relief patients with Currently, therapeutic targets repetitive primarily include brain’s M1, insular, prefrontal cortex regions. Additionally, trans-spinal been reduce spinal cord neuroinflammation, suggesting may serve novel target managing particularly cases injury.

Language: Английский

Citations

0
High-Frequency Repetitive Transcranial Magnetic Stimulation Enhances White Matter Integrity in a Rat Model of Ischemic Stroke: A Diffusion Tensor Imaging Study using Tract-Based Spatial Statistics DOI Creative Commons
Jiemei Chen, Chao Li,

Jiena Hong

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: 311, P. 121204 - 121204

Published: April 11, 2025

Ischemic stroke leads to white matter damage and neurological deficits. Previous studies have revealed that high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) has beneficial effects on reorganization recovery after stroke. However, the characteristics of poststroke repair treatment with HF-rTMS remain unclear. Therefore, this study used diffusion tensor imaging (DTI) investigate impact integrity following middle cerebral artery occlusion (MCAO) in a rat model. The modified severity score (mNSS) T2-weighted data were assess function infarct size. We tract-based spatial statistics (TBSS) approach analyze changes fractional anisotropy (FA) across various tracts. Furthermore, we performed Luxol fast blue (LFB) staining transmission electron microscopy (TEM) detect myelin damage. results compared tMCAO group, tMCAO+rTMS group presented significant decrease size mNSS, as well significantly greater FA values, mostly left external capsule, internal optic tract, deep matter, stria terminalis right capsule. LFB are consistent DTI results. These findings suggest contributes function. This underscores importance noninvasive intervention for enhancing by improving integrity.

Language: Английский

Citations

0
Comparison of the effects of different physical stimulation therapies on reducing upper limb spastic paralysis and motor dysfunction in stroke survivors after stroke: a network meta-analysis of randomized controlled trials DOI Creative Commons

Mingtong Bian,

Fuyan Chen,

Hui‐Zhen Su

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Upper limb spasticity is a common and disabling sequela of stroke, which significantly impairing motor function the capacity to perform activities daily living (ADL). The relative efficacy different physical therapies their combinations compared monotherapies remains unclear. Methods A comprehensive database search was conducted identify randomized controlled trials (RCTs) published from inception 2024 that evaluated for post-stroke upper spasticity. Data were analyzed using RevMan STATA/R software with Bayesian framework network meta-analysis. Evidence consistency assessed via node-splitting approaches, intervention ranked surface under cumulative ranking curve (SUCRA). Effect sizes expressed as mean differences (MD) 95% confidence intervals (CI), study quality Grading Recommendations, Assessment, Development, Evaluations (GRADE) system. Results Forty-nine RCTs involving 3,219 patients included. combination rehabilitation (PR) repetitive transcranial magnetic stimulation (rTMS) electro-acupuncture (EA) demonstrated highest improvement in Fugl-Meyer Assessment Extremity (FMA-UE) scores (91.1%), outperforming PR alone (13.2%) or EA monotherapy (30.3%). combined rTMS body acupuncture (BA) shows most significant Modified Barthel Index (MBI) (83.1%), superior (20.8%) BA (23.8%) alone. Adverse events (e.g., minor bruising EA) infrequent self-resolving. Conclusion Current evidence indicates synergistic application (EA/BA) enhances ADL capacity. However, GRADE evaluations rated moderate quality, limited by implementation bias, insufficient subgroup analyses, lack long-term follow-up data. Future studies should adopt standardized protocols investigate variations across stroke subtypes. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42025633289 , identifier [CRD42025633289].

Language: Английский

Citations

0
Neural correlates of fine motor grasping skills: Longitudinal insights into motor cortex activation using fNIRS DOI Creative Commons
Xiaoli Li, Minxia Jin, Nan Zhang

et al.

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 1, 2024

Motor learning is essential for performing specific tasks and progresses through distinct stages, including the rapid phase (initial skill acquisition), consolidation (skill refinement), stable performance mastery maintenance). Understanding cortical activation dynamics during these stages can guide targeted rehabilitation interventions.

Language: Английский

Citations

3
Clinical Effect Analysis of Wearable Sensor Technology-Based Gait Function Analysis in Post-Transcranial Magnetic Stimulation Stroke Patients DOI Creative Commons
L Wang,

Likai Wang,

Z.-H. Wang

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(10), P. 3051 - 3051

Published: May 11, 2024

(1) Background: This study evaluates the effectiveness of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in improving gait post-stroke hemiplegic patients, using wearable sensor technology for objective analysis. (2) Methods: A total 72 stroke patients were randomized into control, sham stimulation, and LF-rTMS groups, with all receiving standard medical treatment. The group underwent on unaffected hemisphere 6 weeks. Key metrics including Fugl-Meyer Assessment Lower Extremity (FMA-LE), Berg Balance Scale (BBS), Modified Barthel Index (MBI), parameters measured before after (3) Results: showed significant improvements FMA-LE, BBS, MBI, various compared to control groups (p < 0.05). Specifically, FMA-LE scores improved by an average 5 points (from 15 ± 3 20 2), BBS increased 8 35 43 4), MBI rose 10 50 60 7), notable enhancements observed: cycle time was reduced from 2.05 0.51 s 1.02 0.11 s, stride length 0.56 0.04 m 0.97 0.08 m, walking speed 35.95 7.14 cm/s 75.03 11.36 (all p 0.001). No adverse events reported. exhibited but not as significant. (4) Conclusions: significantly enhances lower-limb function, balance, daily living activities subacute showing a improvement. Wearable proves effective providing detailed, analysis, offering valuable insights clinical applications rehabilitation.

Language: Английский

Citations

3