Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 632 - 632

Published: March 13, 2024

Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), present life-threatening conditions characterized by inflammation endothelial injury, leading to increased vascular permeability edema. Key players in the pathogenesis resolution of ALI are macrophages (Mφs) cells (ECs). The crosstalk between these two cell types has emerged as a significant focus for potential therapeutic interventions ALI. This review provides brief overview roles Mφs ECs their interplay ALI/ARDS. Moreover, it highlights significance investigating perivascular (PVMs) immunomodulatory (IMECs) crucial participants Mφ–EC crosstalk. sheds light on paves way innovative treatment approaches.

Language: Английский

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Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 15, 2024

Sepsis is a multi-organ dysfunction characterized by an unregulated host response to infection. It associated with high morbidity, rapid disease progression, and mortality. Current therapies mainly focus on symptomatic treatment, such as blood volume supplementation antibiotic use, but their effectiveness limited. Th17/Treg balance, based its inflammatory property, plays crucial role in determining the direction of regression organ damage sepsis patients. This review provides summary changes T-helper (Th) 17 cell regulatory T (Treg) differentiation function during sepsis, heterogeneity balance response, relationship between damage. exerts significant control over bloom wanes throughout sepsis.

Language: Английский

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Inhalable and bioactive lipid-nanomedicine based on bergapten for targeted acute lung injury therapy via orchestrating macrophage polarization

Bioactive Materials, Journal Year: 2024, Volume and Issue: 43, P. 406 - 422

Published: Oct. 1, 2024

Language: Английский

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Pathophysiological mechanisms of ARDS: a narrative review from molecular to organ-level perspectives

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 13, 2025

Acute respiratory distress syndrome (ARDS) remains a life-threatening pulmonary condition with persistently high mortality rates despite significant advancements in supportive care. Its complex pathophysiology involves an intricate interplay of molecular and cellular processes, including cytokine storms, oxidative stress, programmed cell death, disruption the alveolar-capillary barrier. These mechanisms drive localized lung injury contribute to systemic inflammatory response multiple organ dysfunction syndrome. Unlike prior reviews that primarily focus on isolated mechanisms, this narrative review synthesizes key pathophysiological processes ARDS across molecular, cellular, tissue, levels. By integrating classical theories recent research advancements, we provide comprehensive analysis how mediators, metabolic reprogramming, immune dysregulation synergistically onset progression. Furthermore, critically evaluate current evidence-based therapeutic strategies, such as lung-protective ventilation prone positioning, while exploring innovative therapies, stem therapy, gene immunotherapy. We emphasize significance subtypes their inherent heterogeneity guiding development personalized treatment strategies. This provides fresh perspectives for future research, ultimately enhancing patient outcomes optimizing management approaches ARDS.

Language: Английский

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Laminarin Alleviates Acute Lung Injury Induced by LPS Through Inhibition of M1 Macrophage Polarisation

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

The lipopolysaccharide-induced acute lung injury (ALI) mouse model is used to simulate human respiratory distress syndrome (ARDS), which has a high mortality rate. An imbalance between M1 and M2 macrophages, characterised by an increase in was observed sepsis-induced ALI. We report that laminarin, active ingredient found algae, exhibits exceptional performance of It ameliorates edema, enhances the survival rate mice reduces levels inflammatory factors TNF-α IL-6. Furthermore, laminarin reduced expression CD86, are markers associated with macrophages. Laminarin treatment secretion IL-6 LPS-stimulated also decreases glucose uptake Transcriptome sequencing reveals genes downregulated macrophages following predominantly enriched HIF-1α signalling pathway. Experimental validation confirms significantly related indicators ROS NLRP3. After using siRNA knock down RAW264.7 cells, inhibitory effect on LPS-induced polarisation abolished. This suggests may potentially inhibit macrophage towards phenotype downregulating signal. In conclusion, data presented our study demonstrate can effectively reduce signalling. makes it novel candidate drug for

Language: Английский

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Extracellular vesicles from Candida albicans modulate immune cells function and play a protective role in fungal keratitis

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 189, P. 106606 - 106606

Published: March 2, 2024

Language: Английский

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Biomimetic Nanomodulator Regulates Oxidative and Inflammatory Stresses to Treat Sepsis-Associated Encephalopathy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(41), P. 28228 - 28245

Published: Oct. 5, 2024

Sepsis-associated encephalopathy (SAE) is a devastating complication of sepsis, affecting approximately 70% patients with sepsis in intensive care units (ICU). Although the pathophysiological mechanisms remain elusive, typically accompanied by systemic inflammatory response syndrome (SIRS) and hyper-oxidative conditions. Here, we introduce biomimetic nanomodulator (mAOI NP) that specifically targets inflammation site simultaneously regulates oxidative stresses. mAOI NPs are constructed using metal-coordinated polyphenolic antioxidants (tannic acid) flavonoid quercetin, which then coated macrophage membrane to enhance pharmacokinetics enable SAE targeting. In cecal ligation puncture (CLP)-induced severe model, effectively mitigate stress purging reactive oxygen species, repairing mitochondrial damage activating Nrf2/HO-1 signaling pathway; while polarizing M1 macrophages or microglia toward anti-inflammatory M2 subtype. potently inhibit progress, prolong overall survival from 25 66% learning memory capabilities mice. Further proteomics analysis reveals modulate neurodevelopment processes related formation also exerting antioxidative effects on brain tissue responses associated pathology. This study offers significant potential for improving patient outcomes revolutionizing treatment landscape this sepsis.

Language: Английский

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Sinensetin, a polymethoxyflavone from citrus fruits, ameliorates LPS-induced acute lung injury by suppressing Txnip/NLRP3/Caspase-1/GSDMD signaling-mediated inflammatory responses and pyroptosis

Food & Function, Journal Year: 2024, Volume and Issue: 15(14), P. 7592 - 7604

Published: Jan. 1, 2024

The functional effect and molecular mechanism diagram of SIN ameliorated ALI.

Language: Английский

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Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury

American Journal of Respiratory Cell and Molecular Biology, Journal Year: 2024, Volume and Issue: 71(4), P. 464 - 480

Published: July 3, 2024

Bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment are among the most common morbidities affecting preterm infants. Although BPD is a predictor of poor outcomes, it currently uncertain how contributes to brain injury in Extracellular vesicles (EVs) involved interorgan communication diverse pathological processes. ASC (apoptosis-associated speck-like protein containing caspase recruitment domain) pivotal inflammasome assembly activation inflammatory response. We assessed expression profiles alveolar macrophage (AM) markers CD11b, CD11c, CD206 as well EVs isolated from plasma infants at risk for 1 week age. found that on higher fraction inspired oxygen therapy (HO

Language: Английский

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The new pattern for dual NOTCH pathway involving nuclear transcription and mitochondrial regulation supports therapeutic mechanism of 4-butyl benzophenone derivatives against SIRS

Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 306 - 324

Published: Aug. 10, 2024

Language: Английский

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