VirusDisease, Journal Year: 2025, Volume and Issue: unknown
Published: March 12, 2025
Language: Английский
Clinical & Experimental Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
Abstract Neuro-Behçet’s disease (NBD) is a more severe but rare symptom of Behçet’s (BD), which mainly divided into parenchymal NBD (p-NBD) involving brain stem, spinal cord, and cerebral cortex. Non-p-NBD manifests as intracranial aneurysm, venous thrombosis, peripheral nervous system injuries, mixed non-parenchymal disease. P-NBD pathologically characterized by perivasculitis presenting with cerebrospinal fluid (CSF) pleocytosis, elevated total protein, central (CNS) infiltration macrophages neutrophils, are subdivided acute chronic progressive stages according to relapsing–remitting courses responses steroids. The diagnosis depends heavily on clinical features MRI findings. lack laboratory biomarkers has hindered standard diagnostics. CSF IL-6 the most investigated dimension correlates activity, therapeutic responses, prognosis. Further investigations have focused inflammatory that reflect activation innate adaptive immune responses. Higher levels MIF IAP indicated in CNS; increased IL-17, IL-10, T-bet/GATA-3, ROR-γt /Foxp3 ratios, marking disrupted scale Th1/Th2 Th17/Treg axis; BAFF IgA/IgM intrathecal synthesis, suggesting B cells play dominant role NBD. CNS destruction degeneration consequence neuroinflammatory cascades were confirmed NFL, β2MG, MBP. Autoantibodies, including anti-STIP-1, anti-Mtch1, anti-B-Crystallin anti-m-Hsp65, provide substantial evidence for autoimmune essence underlying microbiological infections immunopathogenesis. We summarized opinions diagnosis, biomarkers, pathological findings
Language: Английский
Citations
2
Cells, Journal Year: 2023, Volume and Issue: 13(1), P. 54 - 54
Published: Dec. 26, 2023
This review analyzes the role of TNF-α and its increase in biological fluids mild cognitive impairment, Alzheimer’s disease (AD). The potential inhibition with pharmacological strategies paves way for preventing AD improving function people at risk dementia. We conducted a narrative to characterize evidence relation involvement possible therapeutic inhibition. Several studies report that patients RA systemic inflammatory diseases treated blocking agents reduce probability emerging dementia compared general population. Animal model also showed interesting results are discussed. An increasing amount basic scientific data clinical underscore importance processes subsequent glial activation pathogenesis AD. targeted therapy is biologically plausible approach cognition preservation further trials necessary investigate benefits populations developing
Language: Английский
Citations
32
Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)
Published: Dec. 18, 2023
Inflammation conditions are associated with autism spectrum disorder (ASD) and cerebral palsy (CP), primarily observed in the peripheral immune system. However, extent of neuro-inflammation neuro-immune dysregulation remains poorly studied. In this study, we analyzed composition cerebrospinal fluid (CSF) to uncover inflammatory mediators driving system ASD CP patients. Our findings revealed that patients had elevated levels four cytokines (TNF-α, IL-4, IL-21, BAFF) compared controls, while exhibited increased eight (IFN-γ, GM-CSF, TNF-α, IL-2, IL-6, IL-17A IL-12), one anti-inflammatory cytokine (IL-10), five growth factors (GFs) (NGF-β, EGF, GDF-15, G-CSF BMP-9) both controls Additionally, intrathecal infusion autologous bone marrow mononuclear cells (BMMNCs) led a slight decrease TGF-β GDF-15 CSF patients, respectively. study provides new insights into molecular potential develop more effective diagnosis methods improved treatment for these diseases.Clinical trial registration samples used from clinical trials NCT03225651, NCT05307536, NCT02569775, NCT03123562, NCT02574923, NCT05472428 previous reports [7, 9, 17-19].
Language: Английский
Citations
27
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: June 3, 2024
Abstract Quantum dots, which won the Nobel Prize in Chemistry, have recently gained significant attention precision medicine due to their unique properties, such as size-tunable emission, high photostability, efficient light absorption, and vibrant luminescence. Consequently, there is a growing demand identify new types of quantum dots from various sources explore potential applications stimuli-responsive biosensors, biomolecular imaging probes, targeted drug delivery agents. Biomass-waste-derived carbon (CQDs) are an attractive alternative conventional QDs, often require expensive toxic precursors, they offer several merits eco-friendly synthesis, preparation renewable sources, cost-effective production. In this study, we evaluated three CQDs derived biomass waste for application non-toxic bioimaging agents cell lines, including human dermal fibroblasts, HeLa, cardiomyocytes, induced pluripotent stem cells, in-vivo medaka fish (Oryzias latipes) model. Confocal microscopic studies revealed that could assist visualizing inflammatory processes were taken up more by cells treated with tumor necrosis factor-α than untreated cells. addition, our quantitative real-time PCR gene expression analysis has citric acid-based can potentially reduce markers Interleukin-6. Our suggest theragnostic agents, simultaneously modulate may lead therapy immune system-associated diseases.
Language: Английский
Citations
13
Human Immunology, Journal Year: 2025, Volume and Issue: 86(2), P. 111232 - 111232
Published: Jan. 9, 2025
Language: Английский
Citations
1
Annals of Clinical and Translational Neurology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Abstract Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. GFAP‐IgG‐positive samples ( N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), GFAP (ELLA, Bio‐Techne). Controls included non‐inflammatory 42), AQP4‐IgG‐positive 83), CNS infections 13), neurosarcoidosis 32). IL5, IL6, IL10, IL8/CXCL8, CXCL9, CXCL10, CXCL13, BAFF, GM‐CSF, IFN‐gamma, TNF‐alpha concentrations higher compared to controls P < 0.01). similar those patients; NfL was 0.001) correlated with MRI changes outcomes. findings in correlate histopathology; hold promise as disease biomarkers.
Language: Английский
Citations
1
Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(2)
Published: Feb. 1, 2025
ABSTRACT Introduction: Repetitive transcranial magnetic stimulation (rTMS) shows promise in treating neuropsychological disorders. This systematic review and meta‐analysis investigated the effects of rTMS on inflammatory cytokines brain‐derived neurotrophic factor (BDNF) under these conditions. Method: We searched five electronic databases for relevant studies. Twelve studies (six randomized controlled trials [RCTs] six cohort studies) were included review, with RCTs meta‐analysis. The primary outcome was tumor necrosis factor‐alpha (TNF‐α) levels, secondary outcomes including interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β), high‐sensitivity C‐reactive protein (hs‐CRP), interferon‐gamma (IFN‐γ), BDNF. Results: Meta‐analysis revealed a significant decrease TNF‐α levels after (weighted mean difference [WMD]: −6.65, 95% confidence interval [CI]: −10.47–2.83, p < 0.05), greater associated longer interventions. No change found IL‐6 levels. BDNF increased significantly (WMD: 7.97, CI: 2.8–13.15, 0.05). Qualitative synthesis indicated consistent reductions IL‐1β. High heterogeneity observed some analyses. Conclusion: may exert therapeutic disorders partly through modulating neuroinflammation promoting neuroplasticity. However, high study limitations necessitate larger, more standardized clinical to confirm explore their significance.
Language: Английский
Citations
1
Clinical & Translational Immunology, Journal Year: 2023, Volume and Issue: 12(12)
Published: Jan. 1, 2023
Abstract Characterised by intraocular inflammation, non‐infectious uveitis includes a large group of autoimmune and autoinflammatory diseases that either involve the eye alone or have both ocular systemic manifestations. When involves posterior segment eye, specifically retina, there is substantial risk vision loss, often linked to breakdown inner blood‐retinal barrier. This barrier formed non‐fenestrated retinal vascular endothelial cells, reinforced supporting cells include pericytes, Müller astrocytes. Across published literature, inflammatory cytokines stand out as prominent mediators with effects on endothelium may contribute barrier, namely tumour necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, IL‐8, IL‐17 chemokine C‐C motif ligand (CCL)2. article reviews function each cytokine discusses evidence for their involvement in dysfunction uveitis, including basic laboratory investigations, studies fluids collected from patients results clinical treatment trials. The review also outlines gaps knowledge this area. Understanding disease processes at molecular level can suggest alternatives are directed against appropriate biological targets protect preserve uveitis.
Language: Английский
Citations
14
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 8, 2024
Abstract Cytokines including tumor necrosis factor, interleukins, interferons, and chemokines are abundantly produced in various diseases. As pleiotropic factors, cytokines involved nearly every aspect of cellular functions such as migration, survival, proliferation, differentiation. Oligodendrocytes the myelin-forming cells central nervous system play critical roles conduction action potentials, supply metabolic components for axons, other functions. Emerging evidence suggests that both oligodendrocytes oligodendrocyte precursor vulnerable to released under pathological conditions. This review mainly summarizes effects on lineage A comprehensive understanding contributes our diseases offers insights into treatment strategies.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1150 - 1150
Published: Jan. 17, 2024
Blast-induced neurotrauma has received much attention over the past decade. Vascular injury occurs early following blast exposure. Indeed, in animal models that approximate human mild traumatic brain or subclinical exposure, vascular pathology can occur presence of a normal neuropil, suggesting vasculature is particularly vulnerable. Brain endothelial cells and their supporting glial neuronal elements constitute neurovascular unit (NVU). Blast disrupts gliovascular connections addition to damaging cells, basal laminae, smooth muscle pericytes as well causing extracellular matrix reorganization. Perivascular becomes associated with phospho-tau accumulation chronic perivascular inflammation. Disruption NVU should impact activity-dependent regulation cerebral blood flow, blood–brain barrier permeability, glymphatic flow. Here, we review work an model low-level have been studying for We locus injury. integrate our findings those from other laboratories similar collectively suggest damage astrocytes immune activation play role persistent neurobehavioral changes follow
Language: Английский
Citations
4