International Journal of Reproductive BioMedicine (IJRM), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 9, 2024
Carbon monoxide (CO), influences ovarian function, pregnancy, and placental health. Heme oxygenase (HO)-1 its products, including CO, exhibit protective anti-inflammatory properties.
Language: Английский
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 98, P. 102323 - 102323
Published: May 9, 2024
Oxidative stress is one of the main driving mechanisms intervertebral disc degeneration(IDD). has been associated with inflammation in disc, cellular senescence, autophagy, and epigenetics cells. It above pathological are closely linked through common hub reactive oxygen species(ROS), promote each other process degeneration development disease. This reveals important role oxidative IDD, importance great potential IDD therapy targeting stress. The efficacy traditional unstable or cannot be maintained. In recent years, due to rise materials science, many bioactive functional have applied treatment combination drugs, satisfactory achieved. At present, research review antioxidant not complete. Based on existing studies, mechanism were summarized this paper, strategies based emerging reviewed.
Language: Английский
Citations
25
ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(2), P. 1125 - 1134
Published: Feb. 6, 2024
Cutaneous trauma repair is still a challenge in the clinic due to scar formation and slow healing rate, especially for diabetic patients. Various drug-loading wound dressings have been explored solve this problem. Mesenchymal stem cell (MSC)-derived exosomes considered as potential cell-free drug because of their anti-inflammation function tissue property that are comparable MSCs. Herein, composite dressing (Exo/Gel) consisting chitosan hydrogel adipose MSC-derived exosome (ADMSC–Exo) was designed fabricated by physical mixing method promote skin full-thickness repair. The were slowly released from Exo/Gel with degradation hydrogel. displayed enhanced migration angiogenic properties vitro. And results rat model showed could regular collagen deposition, angiogenesis, hair follicle mosaicism regeneration. These proved ADMSCs-derived can accelerate healing, which strategy developing dressings.
Language: Английский
Citations
18
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171774 - 171774
Published: March 18, 2024
Language: Английский
Citations
16
Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 9 - 9
Published: Jan. 13, 2025
This study addresses a significant gap in the clinical validation and standardization of exosome-based applications within domains cosmetics regenerative medicine. Despite offering thorough overview potential therapeutic benefits underlying mechanisms exosomes, manuscript underscores several unresolved challenges, including paucity evidence, regulatory barriers, inconsistencies standardization, incomplete mechanistic understanding. The primary aim this research is to conduct systematic comprehensive review existing studies on exosomes skincare. To achieve this, literature was performed, drawing major medical database PubMed. approach facilitated collection meta-analysis relevant data, ensuring rigorous assessment recent advancements exosome research. main outcomes highlight multifaceted roles promoting skin rejuvenation mitigating signs aging. Specific discussed include pigmentation correction, wound healing, tissue repair, innovative delivery mechanisms. Moreover, examines emerging plastic surgery Challenges limitations, such as constraints, hurdles, need for further validation, are critically analyzed, providing framework future directions.
Language: Английский
Citations
1
Advances in Human Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Myocardial ischemia/reperfusion (I/R) injury is a significant concern following reperfusion therapy in ischemic heart disease, often resulting failure, arrhythmia, and adverse cardiac remodeling. Exosomes derived from mesenchymal stem cells (MSCs) have emerged as promising agents to treat this condition. This systematic review protocol adheres the Preferred Reporting Items for Systematic Review Meta-analysis Protocols guidelines Population, Intervention, Comparison, Outcome, Study framework. Comprehensive searches will be conducted Ovid MEDLINE, Scopus, Web of Science databases, using keywords related exosomes MSCs myocardial I/R injury. Eligible studies involve human patients with infarction or injury, animal models cardiomyocyte cell lines. MSC-derived intervention interest, comparator groups receiving no intervention, standard therapy, placebo. Studies involving modified those administrating non-cardiac regions excluded. The risk bias assessed tailored tools clinical, vivo, vitro studies. Meta-analyses where feasible. study provide evidence regarding therapeutic effects mechanisms by which mitigate findings may guide future research on therapies based registered International Platform Registered (INPLASY) registration number: INPLASY2024110023.
Language: Английский
Citations
1
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: Feb. 8, 2024
Vascular dementia (VD) is a prevalent cognitive disorder among the elderly. Its pathological mechanism encompasses neuronal damage, synaptic dysfunction, vascular abnormalities, neuroinflammation, and oxidative stress, others. In recent years, extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have garnered significant attention as an emerging therapeutic strategy. Current research indicates that MSC-derived (MSC-EVs) play pivotal role in both diagnosis treatment of VD. Thus, this article delves into advancements MSC-EVs VD, discussing mechanisms by which EVs influence pathophysiological processes These form theoretical foundation for their neuroprotective effect VD treatment. Additionally, highlights potential applications diagnosis. conclusion, present promising innovative strategy With rigorous ongoing innovation, concept can transition practical clinical treatment, providing more effective options patients.
Language: Английский
Citations
5
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 524 - 540
Published: June 1, 2024
Pulpitis, an inflammatory disease of dental pulp tissues, ultimately results in the loss defense properties. Existing clinical modalities cannot effectively promote inflamed repair. Oxidative stress is a major obstacle inhibiting Due to their powerful antioxidative capacity, mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) exhibit potential for treating oxidative stress-related disorders. However, whether MSC-sEVs shield tissues from damage largely unknown. Here, we showed that follicle sEVs (DFSC-sEVs) have and prohealing effects on rat LPS-induced pulpitis model by enhancing survival, proliferation odontogenesis H2O2-injured cells (DPSCs). Additionally, DFSC-sEVs restored oxidative/antioxidative balance DPSC mitochondria had comparable ameliorating mitochondrial dysfunction with mitochondrion-targeted antioxidant Mito-Tempo. To improve efficacy DFSC-sEVs, fabricated intelligent injectable hydrogel release combining sodium alginate (SA) ROS sensor RhB-AC. The newly formed SA-RhB efficiently encapsulates exhibits controlled HClO/ClO− concentration-dependent manner, providing synergistic effect DFSC-sEVs. These suggest DFSC-sEVs-loaded promising minimally invasive treatment tissue repair wound microenvironment.
Language: Английский
Citations
5
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116008 - 116008
Published: Dec. 9, 2023
The burden of lung diseases is gradually increasing with an increase in the average human life expectancy. Therefore, it necessary to identify effective methods treat and reduce their social burden. Currently, number studies focus on role mesenchymal stem cell-derived exosomes (MSC-Exos) as a cell-free therapy diseases. They show great potential for application more stable safer option than traditional cell therapies. MSC-Exos are rich various substances, including proteins, nucleic acids, DNA. Delivery Non-coding RNAs (ncRNAs) enables communicate target cells. significantly inhibit inflammatory factors, oxidative stress, promote normal proliferation, apoptosis by delivering ncRNAs. Moreover, carrying specific ncRNAs affect invasion, migration cancer cells, thereby playing managing cancer. detailed mechanisms clinical treatment disease were explored developing standardized culture, isolation, purification, administration strategies. In summary, MSC-Exo-based delivery have important prospects treating
Language: Английский
Citations
11
Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 150 - 150
Published: Feb. 1, 2025
Extracellular vesicles (EVs) secreted by umbilical cord-derived mesenchymal stem cells (UC-MSCs) hold significant promise as therapeutic agents in regenerative medicine. This study investigates the effects of UC-MSC-derived EVs on dermal fibroblast function, and their potential wound healing applications. were characterized nanoparticle tracking analysis transmission electron microscopy, revealing a mean size 118.6 nm, consistent with exosomal properties. Dermal fibroblasts treated varying concentrations (25–100 µg/mL), impacts cellular metabolism, mitochondrial activity, reactive oxygen species (ROS) production, closure, inflammatory cytokine secretion, growth factor extracellular matrix (ECM) gene expression evaluated. At lower (25–50 significantly enhanced metabolic activity. However, higher (≥75 µg/mL) increased ROS levels, suggesting hormetic effects. also modulated inflammation reducing pro-inflammatory cytokines (IL-6, TNF-α) while promoting pro-regenerative (IL-33, TGF-β). Treatment 50 µg/mL optimally stimulated closure secretion (VEGF, BDNF, KGF, IGF), upregulated ECM-related (type I III collagen, fibronectin). These findings demonstrate that exert multifaceted including energetics, stimulation cell migration, regulation inflammation, promotion ECM synthesis. highlights novel strategy for tissue regeneration, emphasizing importance optimizing EV concentration maximal efficacy.
Language: Английский
Citations
0
BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 6, 2025
Mucous mesenchymal stem cells can migrate to damaged areas, and their use is proposed as a new approach treating diseases. The present study aimed investigate the effect of oral (OMSCs) on inflammatory, oxidative stress, histopathological indices in tissues stomach, intestine, colon after traumatic brain injury (TBI). Adult male rats were randomly divided into four groups: Sham, TBI, Vehicle (Veh), Stem cell (SC). Intravenous injection OMSCs was performed at 1 24 h injury. small evaluated 48 After IL-1β IL-6 levels increased IL-10 decreased colon, but administration OMSCS prevented these changes large extent. Oxidative stress (MDA, PC, TAC, SOD, CAT) showed an increase less severe OMSC group. TBI improved outcome colon. Administration suffering from improve which shows beneficial using TBI.
Language: Английский
Citations
0