Roles of lncRNAs in NF-κB-Mediated Macrophage Inflammation and Their Implications in the Pathogenesis of Human Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(5), P. 2670 - 2670

Published: Feb. 25, 2024

Over the past century, molecular biology’s focus has transitioned from proteins to DNA, and now RNA. Once considered merely a genetic information carrier, RNA is recognized as both vital element in early cellular life regulator complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles gene expression regulation signal transduction by inducing epigenetic changes or interacting with various RNAs. These interactions exhibit range of functions cell types, including macrophages. Notably, some macrophage lncRNAs influence activation NF-κB, crucial transcription factor governing immune inflammatory responses. Macrophage NF-κB instrumental progression pathological conditions sepsis, atherosclerosis, cancer, autoimmune disorders, hypersensitivity. It orchestrates related responses, inflammation, survival, proliferation. Consequently, its malfunction key contributor onset development these diseases. This review aims summarize function regulating activity particular emphasis on their relevance human diseases potential therapeutic targets. The insights gained studies lncRNAs, discussed this review, could provide valuable knowledge treatments involving

Language: Английский

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Targeting Macrophage Polarization in Infectious Diseases: M1/M2 Functional Profiles, Immune Signaling and Microbial Virulence Factors

Immunological Investigations, Journal Year: 2024, Volume and Issue: 53(7), P. 1030 - 1091

Published: June 24, 2024

An event of increasing interest during host-pathogen interactions is the polarization patrolling/naive monocytes (MOs) into macrophage subsets (MФs). Therapeutic strategies aimed at modulating this are under investigation.

Language: Английский

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Shaping the immune landscape: Multidimensional environmental stimuli refine macrophage polarization and foster revolutionary approaches in tissue regeneration

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37192 - e37192

Published: Aug. 30, 2024

In immunology, the role of macrophages extends far beyond their traditional classification as mere phagocytes; they emerge pivotal architects immune response, with function being significantly influenced by multidimensional environmental stimuli. This review investigates nuanced mechanisms which diverse external signals ranging from chemical cues to physical stress orchestrate macrophage polarization, a process that is crucial for modulation responses. By transitioning between pro-inflammatory (M1) and anti-inflammatory (M2) states, exhibit remarkable plasticity, enabling them adapt influence surroundings effectively. The exploration polarization provides compelling narrative on how these cells can be manipulated foster an environment conducive tissue repair regeneration. Highlighting cutting-edge research, this presents innovative strategies leverage dynamic interplay environment, proposing novel therapeutic avenues harness potential in regenerative medicine. Moreover, critically evaluates current challenges future prospects translating macrophage-centered laboratory clinical applications.

Language: Английский

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Rejuvenating fecal microbiota transplant enhances peripheral nerve repair in aged mice by modulating endoneurial inflammation

Experimental Neurology, Journal Year: 2024, Volume and Issue: 376, P. 114774 - 114774

Published: April 9, 2024

Language: Английский

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Interactions and Trends of Interleukins, PAI-1, CRP, and TNF-α in Inflammatory Responses during the Perioperative Period of Joint Arthroplasty: Implications for Pain Management—A Narrative Review

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 537 - 537

Published: May 17, 2024

Inflammation during the perioperative period of joint arthroplasty is a critical aspect patient outcomes, influencing both pathophysiology pain and healing process. This narrative review comprehensively evaluates roles specific cytokines inflammatory biomarkers in this context their implications for management. Inflammatory responses are initiated propagated by cytokines, which pivotal development acute chronic postoperative pain. Pro-inflammatory play essential up-regulating response, which, if not adequately controlled, leads to sustained impaired tissue healing. Anti-inflammatory work dampen promote resolution. Our discussion extends genetic molecular influences on cytokine production, influence perception recovery rates post-surgery. Furthermore, role PAI-1 modulating inflammation through its impact fibrinolytic system highlights potential as therapeutic target. The modulation these various analgesic anesthetic techniques, including fascia iliac compartment block, demonstrates significant reduction markers, thus underscoring importance targeted strategies. analysis suggests that nuanced understanding interplay between pro-inflammatory anti-inflammatory required. Future research should focus individualized management

Language: Английский

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Tumor‐Associated Macrophages: Key Players in the Non‐Small Cell Lung Cancer Tumor Microenvironment

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(3)

Published: Feb. 1, 2025

ABSTRACT Background Lung cancer is among the most common and deadliest malignant tumors worldwide. It often detected at late stages, resulting in unfavorable outcomes, with tumor cell heterogeneity medication resistance. Tumor‐associated macrophages are key cells contributing to progression. They categorized into two primary phenotypes: Proinflammatory (M1) anti‐inflammatory (M2) which involved onset progression of NSCLC. The role cytokines secreted by lung described, effects various substances such as RNA or protein on differentiation polarization phenotypes highlighted characterize impact immune state therapeutic effect treatments patient prognosis. Researchers have primarily aimed investigate innovative carriers strategies based modify microenvironment. Objectives These approaches integrated other treatments, particularly immunotherapy, enhance efficacy. Methods A comprehensive review was carried out systematically synthesizing existing literature PubMed, using combination keywords “TAMs”, “NSCLC”, “Drug resistance”, “therapy”. available studies were screened for selection quality relevance. Conclusions TAMs promote invasion, growth, metastasis promoting angiogenesis EMT. In addition, they contribute development drug resistance immunosuppressive microenvironment establishment. factors TAM can weaken activity cells, inhibit their killing tumors, leading suppression hindering effectiveness treatment. Therefore, a target immunotherapy. Various being explored, including reducing recruitment influencing treat treatment systems achieve precise delivery drugs gene interfering molecules without causing side effects.

Language: Английский

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Role of efferocytosis in chronic pain —— From molecular perspective

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: 207, P. 106857 - 106857

Published: Feb. 25, 2025

Language: Английский

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Exosomes and MicroRNAs: key modulators of macrophage polarization in sepsis pathophysiology

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 17, 2025

Sepsis is a highly dangerous and complex condition that can result in death. It characterized by strong reaction to an infection, causing dysfunction multiple bodily systems high risk of mortality. The transformation macrophages vital stage the procedure as they possess capability interchange between two separate types: M1, which promotes inflammation, M2, inhibits inflammation. choice greatly affects immune response host. This analysis underscores rapidly expanding roles exosomes microRNAs (miRNAs) regulating trajectory macrophage polarization during episodes sepsis. Exosomes, extremely small extracellular vesicles, facilitate cellular communication transferring biologically active compounds, including miRNAs, proteins, lipids. We investigate impact changes exosome production composition caused sepsis on function. Unique present play significant role controlling crucial signaling pathways govern phenotype macrophages. Through thorough examination recent progress this area, we clarify ways miRNAs derived from either aggravate or alleviate inflammatory reactions occur revelation not only deepens our comprehension underlying mechanisms sepsis, but it also reveals potential new biomarkers targets for treatment. assessment aims amalgamate diverse research investigations propose avenues future influence have body's These entities are essential host's hold important functions mechanism.

Language: Английский

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CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD

Immunobiology, Journal Year: 2025, Volume and Issue: 230(3), P. 152908 - 152908

Published: April 25, 2025

Chronic obstructive pulmonary disease (COPD) is intricately linked to fibrosis, yet the underlying mechanisms remain unclear. This study investigates whether CH25H/25-hydroxycholesterol (25-HC) promotes fibrosis in COPD by modulating AMPK/STAT6-dependent M2 macrophage polarization. Using GEO datasets and a cigarette smoke-induced mouse model, we analyzed CH25H expression fibrotic pathology. was silenced via adeno-associated virus (AAV)-delivered shRNA. Histopathology, flow cytometry, qPCR, Western blotting assessed polarization (M1/M2), AMPK/STAT6 pathway activity. Bone marrow-derived macrophages (BMDMs) were employed validate mechanisms. The role of investigated using specific activator. Analysis database experimental verification showed significantly increased both lung tissues from mice. knockdown alleviated alveolar damage, airway remodeling, mice, evidenced reduced fibrosis-related proteins, improved function, attenuated inflammatory responses. Moreover, inhibited decreased proportion M2-type macrophages. Importantly, levels 25-HC following asso ciated with suppressed activation pathway. Rescue experiments demonstrated that protective effects could be reversed adding AMPKα activator GSK621. Our findings demonstrate CH25H/25-HC exacerbates COPD-associated promoting Targeting may represent novel therapeutic strategy for mitigating COPD.

Language: Английский

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P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function

Purinergic Signalling, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

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