Review of: "The Role of Ferroptosis in Inflammatory Bowel Disease: Mechanisms and Therapeutic Implications" DOI Creative Commons
Qiang Cao

Published: March 5, 2024

Mechanisms and Therapeutic Implications" is an exemplary piece of scientific literature, masterfully written deeply insightful.The comprehensive analysis eloquent presentation the complex mechanisms ferroptosis its implications in pathology Inflammatory Bowel Disease showcase author's profound understanding extensive research field.The meticulous detail, clear articulation, groundbreaking revelations provide invaluable contribution to medical science, particularly context gastrointestinal disorders.The integration current with thoughtful discussion on potential therapeutic targets brilliantly executed, reflecting cutting-edge developments cellular biology their applications improving patient outcomes.This article not only a testament expertise but also beacon knowledge for researchers, clinicians, academicians alike, paving way innovative treatments better IBD.It outstanding work that deserves highest praise widespread recognition significant impact community beyond.

Language: Английский

Efficacy and Safety Assessment of Intrathoracic Perfusion Chemotherapy Combined with immunological factor Interleukin-2 in the Treatment of Advanced Non-Small Cell Lung Cancer: A Retrospective Cohort Study DOI Creative Commons
Qiang Cao, Jinyi Zhu, Xinyan Wu

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(7), P. 2024 - 2032

Published: Jan. 1, 2024

Objective: This study evaluated the efficacy and safety of gemcitabine oxaliplatin intrathoracic perfusion chemotherapy (IPCGOR) regimen combined with interleukin-2 (IL-2) for advanced non-small cell lung cancer (NSCLC).Methods: We conducted a retrospective analysis 460 NSCLC patients from Yunnan Province Early Cancer Diagnosis Treatment Project (June 2020-October 2022), assessing IPCGOR IL-2 combination.Outcomes were measured based on RECIST 1.1 criteria, focusing objective response rate (ORR), disease control (DCR), median progression-free survival (mPFS), overall (MOS), treatment safety.Results: The demonstrated an ORR 67.4%, DCR 97.4%, mPFS 8.5 months, MOS 12.5 months.14 underwent successful surgery post-treatment.Common adverse reactions manageable, no treatment-related deaths reported. Conclusion:The shows promising tolerable profile NSCLC.These findings suggest its potential as reference treating NSCLC.However, study's nature single-center design pose limitations.Future research should focus prospective studies, randomized controlled trials, long-term outcome assessments, particularly in diverse patient subgroups, to further validate refine clinical application this regimen.

Language: Английский

Citations

17
Mechanisms of action of the BCL-2 inhibitor venetoclax in multiple myeloma: a literature review DOI Creative Commons
Qiang Cao, Xinyan Wu, Qi Zhang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 6, 2023

Abnormal cellular apoptosis plays a pivotal role in the pathogenesis of Multiple Myeloma (MM). Over years, BCL-2, crucial anti-apoptotic protein, has garnered significant attention MM therapeutic research. Venetoclax (VTC), small-molecule targeted agent, effectively inhibits promoting programmed death cancerous cells. While VTC been employed to treat various hematological malignancies, its particular efficacy showcased potential for broader clinical applications. In this review, we delve into intricacies how modulates cells by targeting BCL-2 and overarching influence protein family regulation. Our findings highlight nuanced interplay between VTC, MM, offering insights that may pave way optimizing strategies. Through comprehensive analysis, aim lay solid groundwork future explorations VTC’s applications profound effects on apoptosis.

Language: Английский

Citations

27
Therapeutic efficacy of rare earth carbonate with chemoradiotherapy in late-stage non-small cell lung cancer: a cohort prospective study DOI Creative Commons
Qiang Cao, Xia Ye, Xinyan Wu

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 15, 2023

To compare the therapeutic effects and adverse reactions of sterilizing rare earth carbonate combined with concurrent chemoradiotherapy simple in treatment late-stage non-small cell lung cancer (NSCLC), to analyze reasons for differences. A total 817 patients pathologically diagnosed NSCLC from June 1, 2021 December 30, 2022, affiliated hospital Kunming University Science Technology, were selected. They randomly divided into a control group 394 people an experimental 423 people. The was given (cisplatin + etoposide), while simultaneously took low dose sterilized (0.05mg/Kg). χ² test Fisher's used clinical pathological features, objective response rate (ORR), ECOG score, two groups patients, survival analysis progression-free (PFS) groups. Cox regression factors related prognosis. differences features between not statistically significant, all P>0.05. ORR 45.18% (178/394), 89.83% (380/423), significant difference (P=0.001). After treatment, score lower than that group, P<0.001. reaction grading both below level 3 after no treatment-related fatalities occurred. risk pulmonary infection bone marrow suppression group. In compared chemoradiotherapy, combination can significantly improve short-term effect prognosis good safety.

Language: Английский

Citations

15
Integrating UHPLC-Q-TOF-MS/MS, Network Pharmacology, Bioinformatics and Experimental Validation to Uncover the Anti-cancer Mechanisms of TiaoPi AnChang Decoction in Colorectal Cancer DOI

Yantong Guo,

Chunsheng Yuan,

Ting Huang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118576 - 118576

Published: July 14, 2024

Language: Английский

Citations

6
A Treg‐related riskscore model may improve the prognosis evaluation of colorectal cancer DOI
Qingqing Li, Yuxin Chu, Yi Yao

et al.

The Journal of Gene Medicine, Journal Year: 2024, Volume and Issue: 26(2)

Published: Feb. 1, 2024

Abstract Background Colorectal cancer (CRC) poses a significant health challenge. This study aims to investigate the prognostic value of regulatory T cell (Treg)‐related gene signature in CRC. Methods We extracted expression and clinical data on CRC from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. module related Treg was identified by weighted co‐expression network analysis (WGCNA). genes were filtered univariate Cox, least absolute shrinkage selection operator (LASSO) multivariate Cox regression analysis. A riskscore model established terms key Treg‐related genes. reliability this validated using external GEO dataset. association with features, mutation patterns signaling pathways explored. Results Genes blue showed strongest Tregs. After series filtering cycles, seven genes, GDE1, GSR, HSPB1, AOC2, TBX19, TAMM41 TIGD6, selected construct model. performed well evaluating patients’ survival TCGA cohort, further affirmed GSE17536 validation cohort. For precise evaluation survival, we nomogram light factors. Patients different risk groups had distinct pathway activities. five significantly associated infiltration samples. Conclusion useful may contribute prognosis evaluation, direct tailored treatment, hopefully improve outcomes patients.

Language: Английский

Citations

4
Cathepsin L promotes oesophageal squamous cell carcinoma development and may be associated with tumour-associated macrophages DOI Creative Commons

Zhenhu Zhang,

Jianyu Wang,

Yamin Shi

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e29273 - e29273

Published: April 1, 2024

BackgroundOesophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related deaths worldwide because existing treatments are often insufficient. Therefore, new, reliable biomarkers must be identified. CTSL overexpression closely associated with tumour progression and poor prognosis. However, the role mechanism as an oncogene in ESCC remain unclear.MethodsGenome-wide association study (GWAS) data were used for Mendelian randomization analysis to investigate possible relationships between ESCC. The correlation expression prognosis was analysed using GEO, TCGA, GEPIA data. We compared among types single-cell sequencing. Correlations microenvironment, immune infiltration, mutational load, immunological checkpoints, treatment sensitivity patients investigated. Finally, mouse models cellular investigations, we assessed effects on growth, apoptosis, metastasis cells.ResultsCTSL overexpressed correlated also discovered its close immunity, especially tumour-associated macrophages checkpoints microenvironment. may play key development by affecting M2 macrophage polarisation. marker genes showed significant positive correlations. confirmed relationship our vitro vivo experiments demonstrated that promoted proliferation migration cells, validating bioinformatic analysis.ConclusionCTSL emerged crucial gene influences patient particularly macrophages. targeting or modulating levels provide new therapeutic strategies

Language: Английский

Citations

4
Lights and Shadows of Cytokines in Age‐Related Eye Diseases: A Narrative Literature Review DOI Open Access

Yuyu Xue,

Lu Ye,

Chan Huang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(1)

Published: Jan. 1, 2025

ABSTRACT The eye is considered to be an immune‐privileged region. However, several parts of the have distinct mechanisms for delivering immune cells injury sites or even in response aging. Although these responses are intended protective, visual acuity can compromised by release pro‐inflammatory cytokines cells, which induce chronic inflammation and fibrosis. Age‐related diseases (AREDs) primary cause vision impairment (VI) elderly, with a poor comprehension their pathophysiology. affect both anterior posterior segments, resulting diminished quality life risk irreversible blindness. Immune system dysregulation upregulation been linked AREDs, underscoring need comprehend inflammation's impact on ocular disorders enhance patient symptom management. In this framework, PubMed database was searched using medical subject headings (MeSH) terms “Age‐related diseases,” “dry syndrome,” “glaucoma,” “cataract,” “diabetic retinopathy,” “inflammation,” “interleukin,” “cytokine” aim overview role AREDs discuss potential therapeutic approaches.

Language: Английский

Citations

0
Human platelet lysate: a potential therapeutic for intracerebral hemorrhage DOI Creative Commons

Dachang Qiu,

Lin Wang, Lanlan Wang

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 15, 2025

Intracerebral hemorrhage (ICH) is a major public health challenge worldwide, and associated with elevated rates of mortality, disability, morbidity, especially in low- middle-income nations. However, our knowledge the detailed molecular processes involved ICH remains insufficient, particularly those secondary injury stage, resulting lack effective treatments for ICH. Human platelet lysates (HPL) are abundant bioactive factors, numerous studies have demonstrated their beneficial effects on neurological diseases, including anti-neuroinflammatory ability, anti-oxidant effects, maintenance blood-brain barrier integrity, promotion neurogenesis. In this review, we thoroughly explore potential HPL treating from three critical perspectives: rationale selecting as treatment ICH, mechanisms through which contributes to management, additional measures necessary We elucidate role platelets pathophysiology highlight limitations current options advancements preclinical research application disorders. Furthermore, historical developments preparation methods field biomedicine discussed. Additionally, summarize molecules present therapeutic Finally, outline issues that must be addressed regarding utilizing modality

Language: Английский

Citations

0
Development Trends in the Clinical Test of Multiple Myeloma from 2000 to 2023: A Bibliometric Study DOI Creative Commons
Hongcheng Wu,

Haomiao Sun,

Yichen Wang

et al.

Published: Jan. 9, 2025

Objective: This study investigates the development trends and research hotspots in clinical testing for multiple myeloma from 2000 to 2023, using bibliometric techniques. Method: Search relevant literature on of published Web Science Core Collection (WoSCC) use CiteSpace 6.2.R4 software draw a visual knowledge map authors, institutions, national regional cooperation networks, journals, keywords, conduct analysis. Results: The found an upward trend publications over specified period, with significant growth noted 2012 onwards. majority originates United States, contributions institutions like Mayo Clinic MD Anderson Cancer Center. Analysis author collaboration networks indicated relatively low centrality, suggesting minimal among researchers. Bibliometric mapping highlighted several field including therapeutic strategies involving proteasome inhibitors immunomodulatory drugs, role stem cell transplantation, importance achieving monitoring residual disease. Conclusion: is characterized by growing body research, States. Despite increasing volume there need enhanced researchers consolidate findings advance practice.

Language: Английский

Citations

0
IgG4-mediated M2 macrophage polarization in tertiary lymphoid structures of esophageal cancer: implications for immunosuppression DOI Creative Commons
Hui Wang, Jirui Li, Wang Yinghai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Our previous research highlighted the potential role of immunoglobulin G4 (IgG4) in mediating immunosuppression within tumor microenvironment (TME). Tertiary lymphoid structures (TLS) TME have important immune-related functions. This study aims to analyze distribution characteristics IgG4-expressing cells, regulatory T cells (Tregs), and M2-type macrophages as well elucidate relationship between IgG4 polarization M2 TLS esophageal cancer. To IgG4, Treg assess impact on macrophage polarization. Esophageal cancer tissue were analyzed with multiplex immunofluorescence determine spatial density B their subtypes. The CD8+ TLS, along interleukin-10 (IL-10) expression presence, was studied. Serum IL-10 levels compared patients healthy controls. In vitro, monocyte differentiation into observed. inversely related mature indicating a immunosuppressive (P<0.05,*). analysis revealed that both (P<0.01, **) (P<0.0001, ****) significantly elevated positively correlated controls **). vitro experiments confirmed macrophages, potentially enhancing phenotype TLS. may contribute by promoting which could be therapeutic target.

Language: Английский

Citations

0