Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104545 - 104545
Published: Oct. 1, 2024
Language: Английский
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Feb. 25, 2025
Microorganisms, including bacteria, viruses, and fungi, have been found to play critical roles in tumor microenvironments. Due their low biomass other obstacles, the presence of intratumor microbes has challenging definitively establish. However, advances biotechnology enabled researchers reveal association between microbiota cancer. Recent studies shown that tissues, once thought be sterile, actually contain various microorganisms. Disrupted mucosal barriers adjacent normal tissues are important sources microbiota. Additionally, can invade tumors by traveling through bloodstream site infiltrating damaged blood vessels. These may promote initiation progression cancers inducing genomic instability mutations, affecting epigenetic modifications, activating oncogenic pathways, promoting inflammatory responses. This review summarizes latest advancements this field, techniques methods for identifying culturing microbiota, potential sources, functions, efficacy immunotherapy. It explores relationship gut cancer patients, whether altering might influence characteristics host immune microenvironment. discusses prospects limitations utilizing antitumor
Language: Английский
Citations
0
Gut Microbes Reports, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 12
Published: March 12, 2025
Language: Английский
Citations
0
EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105708 - 105708
Published: April 22, 2025
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)
Published: May 5, 2025
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 25, 2024
Abstract Tumors of the digestive system pose a significant threat to human health and longevity. These tumors are associated with high morbidity mortality rates, leading heavy economic burden on healthcare systems. Several intratumoral microorganisms present in tumors, their sources abundance display heterogeneity depending specific tumor subtype. microbes have complex precise function neoplasm. They can facilitate growth through various mechanisms, such as inducing DNA damage, influencing antitumor immune response, promoting degradation chemotherapy drugs. Therefore, these be targeted inhibit progression for improving overall patient prognosis. This review focuses current research progress how they influence initiation, progression, prognosis tumors. Furthermore, primary constituents microbiome delineated. Finally, we summarize application potential diagnosis, treatment, prediction
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7091 - 7091
Published: June 28, 2024
Breast cancer (BC) continues to pose a significant burden on global cancer-related morbidity and mortality, primarily driven by metastasis. However, the combined influence of microRNAs (miRNAs) intratumoral microbiota BC metastasis remains largely unexplored. In this study, we aimed elucidate interplay between composition, miRNA expression profiles, their collective development in patients employing 16S rRNA sequencing qPCR methodologies. Our findings revealed an increase miR-149-5p, miR-20b-5p, miR-342-5p metastatic breast (Met-BC) patients. The Met-BC exhibited heightened microbial richness diversity, attributed diverse pathogenic bacteria. Taxonomic analysis identified several pro-inflammatory species enriched Met-BC, contrasting with non-metastatic (NonMet-BC) patients, which displayed enrichment potential probiotic anti-inflammatory species. Notably, verified baseline prognostic signature for its clinical relevance further validated impact overall survival. conclusion, observed disparities species-level bacterial abundance suggest involvement progression. holds promise risk assessment, paving way personalized interventions improved outcomes
Language: Английский
Citations
3
Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 917 - 917
Published: July 27, 2024
Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores interplay between intratumoral microbiota, tumor metabolism, major types GI (including esophageal, gastric, liver, pancreatic, colorectal cancers), summarizing recent studies elucidating clinical implications future directions. Recent research revealed altered microbial signatures within tumors, impacting progression, immune responses, outcomes. Dysbiosis-induced alterations in including glycolysis, fatty acid amino play critical roles cancer progression therapeutic resistance. The integration molecular mechanisms potential biomarkers into this further enhances prognostic significance microbiota composition opportunities targeting microbiota-mediated metabolism. Despite advancements, challenges remain dynamic interactions microenvironment (TME). Future directions, advanced omics technologies prospective studies, offer promising avenues precision oncology personalized interventions cancer. Overall, integrating microbiota-based approaches management holds promise improving patient outcomes survival.
Language: Английский
Citations
3
Journal of Pharmaceutical Analysis, Journal Year: 2024, Volume and Issue: 15(2), P. 101067 - 101067
Published: Aug. 13, 2024
Exosomal circRNAs are pivotal in cancer biology, and tumor pathophysiology. These stable, non-coding RNAs encapsulated exosomes participated progression, growth, metastasis, drug sensitivity the microenvironment (TME). Their presence bodily fluids positions them as potential non-invasive biomarkers, revealing molecular dynamics of cancers. Research exosomal is reshaping our understanding neoplastic intercellular communication. Exploiting natural properties for targeted delivery disrupting circRNA-mediated pro-tumorigenic signaling can develop new treatment modalities. Therefore, ongoing exploration research poised to revolutionize clinical management cancer. This emerging field offers hope significant breakthroughs care. review underscores critical role biology resistance, highlighting their biomarkers therapeutic targets that could transform
Language: Английский
Citations
2
Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3040 - 3040
Published: Aug. 31, 2024
Cumulative evidence attests to the essential roles of commensal microbes in physiology hosts. Although microbiome has been a major research subject since time Luis Pasteur and William Russell over 140 years ago, recent findings that certain intracellular bacteria contribute pathophysiology healthy vs. diseased tissues have brought field new era investigation. Particularly, breast cancer research, breast-tumor-resident are now deemed be players tumor initiation progression. This is resurrection Russel's bacterial cause theory, which was fact abandoned 100 ago. review will introduce some exemplify carcinogenesis metastasis provide mechanistic explanations for these phenomena. Such information would able justify utility as biomarkers disease progression therapeutic targets.
Language: Английский
Citations
2
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(11), P. 1083 - 1083
Published: Oct. 31, 2024
The human microbiota represents a heterogeneous microbial community composed of several commensal, symbiotic, and even pathogenic microorganisms colonizing both the external internal body surfaces. Despite term "microbiota" being commonly used to identify inhabiting gut, pieces evidence suggest presence different physiologically other organs. In this context, studies have also confirmed that microbes are integral components tumor tissue in types cancer, constituting so-called "intratumoral microbiota". intratumoral is closely related occurrence development cancer as well efficacy anticancer treatments. Indeed, can contribute carcinogenesis metastasis formation some directly cause DNA damage, while others induce activation proinflammatory responses or oncogenic pathways alter microenvironment (TME). All these characteristics make an interesting topic investigate for diagnostic prognostic purposes order improve management patients. This review aims gather most recent data on role development, progression, response treatment, its potential value.
Language: Английский
Citations
2