Role of the TME in immune checkpoint blockade resistance of non-small cell lung cancer DOI Open Access
Yuening Dai, Xi Tian,

Xuanting Ye

et al.

Cancer Drug Resistance, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Primary and secondary resistance to immune checkpoint blockade (ICB) reduces its efficacy. The mechanisms underlying immunotherapy are highly complex. In non-small cell lung cancer (NSCLC), these primarily associated with the loss of programmed death-ligand 1 (PD-L1) expression, genetic mutations, circular RNA axis transcription factor regulation, antigen presentation disorders, dysregulation signaling pathways. Additionally, alterations in tumor microenvironment (TME) play a pivotal role driving resistance. is mainly attributed TME alterations, including mutations co-mutations, modulation T infiltration, enrichment M2 tumor-associated macrophages (M2-TAMs) mucosal-associated invariant (MAIT) cells, vascular endothelial growth (VEGF), pulmonary fibrosis. Acquired stems from changes cellular infiltration patterns leading “cold” or “hot” tumors, altered interferon (IFN) pathway involvement extracellular vesicles (EVs), oxidative stress responses, as well post-treatment gene circadian rhythm disruption (CRD). This review presents an overview various ICB, elucidates during primary, adaptive, acquired resistance, discusses existing strategies for overcoming ICB

Language: Английский

Evaluation of efficacy, safety and underlying mechanism on Traditional Chinese medicine as synergistic agents for cancer immunotherapy: A preclinical systematic review and meta-analysis DOI
Jing Li, Shipeng Fan, Hongxia Li

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119035 - 119035

Published: Nov. 5, 2024

Language: Английский

Citations

6
Saffron improves the efficacy of immunotherapy for colorectal cancer through the IL-17 signaling pathway DOI Creative Commons
Siqi Feng, Shiying Li,

Zhong-Hua Wu

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118854 - 118854

Published: Sept. 24, 2024

Language: Английский

Citations

5
Salidroside enhances 5-fluorouracil sensitivity against hepatocellular carcinoma via YIPF5-induced mitophagy DOI Creative Commons

Sumin Sun,

Haili Hu,

Feiyu Li

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Hepatocellular carcinoma (HCC) is a major medical challenge due to its high incidence and poor prognosis. 5-Fluorouracil (5-FU), although extensively studied in the treatment of HCC other solid tumors, has limited application as first-line therapy for resistance significant inter-patient variability. To address these issues, researchers have explored drug repurposing. One our key findings this endeavour was potent anti-HCC effect natural product Salidroside (Sal) when co-administered with 5-FU. Sal found inhibit mitosis promote cellular senescence cells via mechanism distinct from 5-FU, specifically by inducing excessive mitophagy that led mitochondrial dysfunction. Importantly, YIPF5 confirmed potential molecular target Sal. This modulated YIPF5-induced influenced both cells. The combination 5-FU demonstrated therapeutic effects mouse model. In conclusion, study not only line innovative strategy repurposing, but also important design screening targeting relevant pathways.

Language: Английский

Citations

0
Mechanistic insights into the role of traditional Chinese medicine in treating gastric cancer DOI Creative Commons
Ziqiang Chen, Ting Yu, Yunhe Wang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 21, 2025

Gastric cancer remains a leading cause of cancer-related mortality worldwide, with advanced stages presenting significant challenges due to metastasis and drug resistance. Traditional Chinese Medicine (TCM) offers promising complementary approach characterized by holistic treatment principles minimal side effects. This review comprehensively explores the multifaceted mechanisms which TCM addresses gastric cancer. Specifically, we detail how inhibits aerobic glycolysis downregulating key glycolytic enzymes metabolic pathways, thereby reducing energy supply essential for cell proliferation. We examine suppresses angiogenesis targeting vascular endothelial growth factor (VEGF) cyclooxygenase-2 (COX-2) effectively starving tumors nutrients oxygen required metastasis. Furthermore, modulates immune microenvironment enhancing activity effector cells such as CD4 + CD8 T natural killer (NK) while immunosuppressive like regulatory (Tregs) myeloid-derived suppressor (MDSCs). These actions collectively contribute slowing tumor progression, inhibiting metastasis, body’s antitumor response. The insights presented underscore potential an integral component comprehensive strategies, highlighting avenues future research clinical application improve patient outcomes.

Language: Английский

Citations

0
Nanoparticle-based Traditional Chinese Medicine for Immunotherapy in Gastrointestinal Tumors DOI Creative Commons

Linjia Peng,

Yan‐Feng Liang,

Qiuli Zhang

et al.

Nano Biomedicine and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Research progress of nano drug delivery systems in the anti-tumor treatment of traditional Chinese medicine monomers DOI Creative Commons
Bocui Song, Shuang Li, Shuang Zhang

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19332 - e19332

Published: April 24, 2025

Tumors pose a serious threat to global public health and are usually treated from two aspects: tumor cells microenvironment. Compared with traditional chemotherapy drugs, Chinese medicine (TCM) monomers have advantages in treatment, such as multiple targets, levels synergistic intervention. However, most TCM active ingredients disadvantages poor water solubility stability, which restrict their clinical application. Nano drug delivery systems the functions of improving bioavailability anti-tumor ingredients, enhancing tissue targeting, achieving controlled release, inhibiting multidrug resistance. free monomers, they higher therapeutic effects fewer side effects. This article summarizes five commonly used monomer nanocarriers, including lipid nanomaterials, exosomes, polymer micelles, carbon nanotubes, dendrimers, explains mechanisms after combining TCM, cell proliferation metastasis, regulating microenvironment, etc . At same time, potential nano combined radiotherapy immunotherapy is discussed, well current problems toxicity, long-term complex amplification process, future development directions, aiming provide reference for promoting application ingredients.

Language: Английский

Citations

0
Traditional Chinese Medicine in Regulating Tumor Microenvironment DOI Creative Commons
Ziwei Wang, Mengyao Li, Ling Bi

et al.

OncoTargets and Therapy, Journal Year: 2024, Volume and Issue: Volume 17, P. 313 - 325

Published: April 1, 2024

Tumor microenvironment (TME) is a complex and integrated system containing variety of tumor-infiltrating immune cells stromal cells.They are closely connected with cancer influence the development progression cancer.Traditional Chinese medicine (TCM) an important complementary therapy for treatment in China.It mainly eliminates by regulating TME.The aim this review to systematically summarize crosstalk between tumor TME, research progress TCM great significance revealing therapeutic mechanism action TCM, provides opportunity combined application immunotherapy treatment.

Language: Английский

Citations

3
Application and research progress of cordycepin in the treatment of tumours (Review) DOI
Ru He, Wence Zhou

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(3)

Published: July 8, 2024

Cordycepin is a nucleoside molecule found in

Language: Английский

Citations

3
The Latest Research Progress: Active Components of Traditional Chinese Medicine as Promising Candidates for Ovarian Cancer Therapy DOI

Xiaoyu Zhang,

Xiaocen Wei,

Lei Shi

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118811 - 118811

Published: Sept. 7, 2024

Language: Английский

Citations

3
Exploring HMMR as a therapeutic frontier in breast cancer treatment, its interaction with various cell cycle genes, and targeting its overexpression through specific inhibitors DOI Creative Commons

Aisha Shabir,

Hina Qayoom,

Burhan Ul Haq

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: March 21, 2024

Among women, breast carcinoma is one of the most complex cancers, with highest death rates worldwide. There have been significant improvements in treatment methods, but its early detection still remains an issue to be resolved. This study explores multifaceted function hyaluronan-mediated motility receptor (HMMR) cancer progression. HMMR's association key cell cycle regulators (AURKA, TPX2, and CDK1) underscores pivotal role initiation advancement. involvement microtubule assembly cellular interactions, both extracellularly intracellularly, provides critical insights into contribution processes. Elevated HMMR expression triggered by inflammatory signals correlates unfavorable prognosis various other malignancies. Therefore, recognizing as a promising therapeutic target, validates overexpression pan cancers correlation certain proteins such AURKA, CDK1 through online databases. Furthermore, pathways associated were explored using pathway enrichment analysis, Gene Ontology, offering foundation for development effective strategies treatment. The further highlights compounds capable inhibiting pathways, which, turn, would inhibit upregulation cancer. results validated via MD simulations addition molecular docking explore protein-protein/ligand interaction. Consequently, these findings imply that could play crucial oncogenic regulator, highlighting potential target intervention carcinoma.

Language: Английский

Citations

2