Unlocking the therapeutic capabilities of GPCR in the treatment of ischemic stroke: A translational literature DOI Creative Commons

Brunda Girish,

B S Nikitha,

K Roopa

et al.

Medicine in Drug Discovery, Journal Year: 2024, Volume and Issue: 24, P. 100197 - 100197

Published: Aug. 23, 2024

GPCRs are a class of membrane proteins that essential to signal transduction, and this is vital process in many different physiologies. The significant mortality rate widespread occurrence stroke highlight the need accelerate research develop viable treatment agents. A promising prospect for development new approaches increasing comprehension pathophysiology crucial roles played by GPCRs. Because blood clot, glial cells' vascular supply abruptly cut off, which sets off series events include inflammation neuronal damage ultimately lead cell death. Numerous therapeutic treatments, including thrombolytic agents like tissue plasminogen activator urokinase, have been discovered as potential neuroprotective medicines; however, their use restricted because modest window. Accepting pertinent factors ischemic stroke, we explore medicinal promise GPCR-targeted treatments shortcomings ought be resolved order translate these discoveries clinical cases.

Language: Английский

Esculentoside H reduces the PANoptosis and protects the blood-brain barrier after cerebral ischemia/reperfusion through the TLE1/PI3K/AKT signaling pathway DOI
Kuo Zhang, Zhichao Wang,

Hongxue Sun

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114850 - 114850

Published: June 12, 2024

Language: Английский

Citations

8
DL-3-n-Butylphthalide Ameliorates Post-stroke Emotional Disorders by Suppressing Neuroinflammation and PANoptosis DOI

Yanhui Cui,

Zhaolan Hu,

Laifa Wang

et al.

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(8), P. 2215 - 2227

Published: June 4, 2024

Language: Английский

Citations

6
Association between HALP (hemoglobin, albumin, lymphocyte, and platelet) score and poor outcomes in acute ischemic stroke patients with type 2 diabetes mellitus: a study from the Third China National Stroke Registry DOI Creative Commons
Xu Zhu, Yijun Zhang,

Anxin Wang

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

The combined index (HALP) of hemoglobin, albumin, lymphocytes, and platelets is considered a novel scoring system that reflects systemic inflammation nutritional status. This study aimed to investigate the relationship between HALP scores poor outcomes in acute ischemic stroke (AIS) patients with type 2 diabetes mellitus (DM). Patients AIS DM were screened from Third China National Stroke Registry (CNSR-III) divided into quartiles based on their at admission. Clinical adverse functional (modified Rankin scale [mRS] score 3-6 or 2-6) all-cause mortality 3 months 1 year. association risk outcome analyzed by multivariable logistic regression Cox proportional hazards regression. A total 3,603 included this study. After adjusting for confounders, it was found highest quartile had lower mRS 2-6 (odds ratio [OR], 0.64; 95% confidence interval [CI], 0.51-0.80) (OR, 0.53; CI, 0.51-0.82) 3-month follow-up. At 1-year follow-up, significant correlation observed 0.65; 95%CI, 0.57-0.81) 0.47-0.86). Additionally, associated reduced follow-up (hazard [HR], 0.35; 0.13-0.93). Similar results (HR, 0.34; 0.18-0.63). poorer mortality.

Language: Английский

Citations

0
NDUFA11 may be the disulfidptosis-related biomarker of ischemic stroke based on integrated bioinformatics, clinical samples, and experimental analyses DOI Creative Commons
Sijun Li, Ningyuan Chen,

Junrui He

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 18

Published: Jan. 14, 2025

Background Programmed cell death plays an important role in neuronal injury and after ischemic stroke (IS), leading to cellular glucose deficiency. Glucose deficiency can cause abnormal accumulation of cytotoxic disulfides, resulting disulfidptosis. Ferroptosis, apoptosis, necroptosis, autophagy inhibitors cannot inhibit this novel programmed mechanism. Nevertheless, the potential mechanisms disulfidptosis IS remain unclear. Methods The GSE16561 dataset was used screen for differentially expressed disulfidptosis-related biomarkers (DE-DRBs). A correlation between DE-DRBs detected. optimal machine-learning (ML) model predictor molecules were determined. GSE58294 verify accuracy ML model. DE-DRB expression detected blood patients with IS. Based on models, experimental analyses performed DE-DRBs. Results Leucine-rich pentatricopeptide repeat-containing (LRPPRC) NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (NDUFA11) identified as NADH: ubiquinone oxidoreductase core S1 (NDUFS1) interacted NDUFA11 LRPPRC. support vector machine (SVM) level 20.9% compared that normal controls. downregulated vitro/in vivo models number formed complexes NDUFS1 decreased Conclusion This research suggests is a specific DRB demonstrates alterations protein NDUFS1-NDUFA11.

Language: Английский

Citations

0
Neuroprotective potential of ApoE-mimetic peptide (ApoEFrag) in stroke models: Neurobehavioural and mechanistic study DOI
Sakeel Ahmed,

Rajan K. Tripathy,

Abhay H. Pande

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140790 - 140790

Published: Feb. 1, 2025

Language: Английский

Citations

0
Immune genes involved in synaptic plasticity during early postnatal brain development contribute to post-stroke damage in the aging male rat brain DOI Creative Commons

Denisa Pîrșcoveanu,

Denissa Greta Olaru,

Dirk M. Hermann

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 18, 2025

Language: Английский

Citations

0
Untargeted metabolomics unveils critical metabolic signatures in novel phenotypes of acute ischemic stroke DOI
Yao Jiang, Qian Wu,

Yingqiang Dang

et al.

Metabolic Brain Disease, Journal Year: 2025, Volume and Issue: 40(3)

Published: Feb. 19, 2025

Language: Английский

Citations

0
One-stone-four-birds strategy to construct magnetic mesoporous nano-ratio fluorescence sensor for efficient discovery of PSD95-nNOS uncouplers DOI
Tao Peng, Lu Xu, Yang Jin

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161330 - 161330

Published: March 1, 2025

Language: Английский

Citations

0
Calycosin Inhibit PANoptosis and Alleviate Brain Damage: A Bioinformatics and Experimental Verification Approach DOI

Huiyan An,

Chongyu Shao, Yu He

et al.

ACS Chemical Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

PANoptosis is a newly identified form of cell death that encompasses pyroptosis, apoptosis, and necroptosis. Numerous studies have highlighted the significance in brain ischemia-reperfusion (I/R) injury. Calycosin, natural product with diverse biological activities, has demonstrated significant reduction neuronal caused by ischemic injury modulating multiple pathways. In order to investigate potential mechanisms underlying neuroprotective role calycosin alleviating PANoptosis-induced damage stroke therapy, we used mouse hippocampal line HT22 stimulate ischemia vitro through Oxygen Glucose Deprivation/Reperfusion (OGD/R) established molecular docking assess binding affinity Calycosin key targets dynamics simulations (MDS) study stability ligand-protein complex. The results demonstrate could improve growth HT22, leading enhanced viability, reduced lactate dehydrogenase leakage, decreased apoptosis after OGD/R. It also regulated expression PANoptosis-related genes such as NLRP3, GSDMD, MLKL, RIPK1 increased Bcl-2/Bax ratio, effectively reducing cellular providing protection. Molecular MDS strong activity between targets. Furthermore, successfully passed drug similarity (DS) evaluation exhibited favorable absorption, distribution, metabolism, excretion, toxicity (ADMET) properties activity. conclusion, alleviate inhibiting PANoptosis, inflammation improving Thus, it serve therapy for stroke.

Language: Английский

Citations

0
An emerging role of SNAREs in ischemic stroke: From pre-to post-diseases DOI Creative Commons
Yaxin Liu, Jung Hwa Hong, Guozuo Wang

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116907 - 116907

Published: March 1, 2025

Ischemic stroke is a debilitating condition characterized by high morbidity, disability, recurrence, and mortality rates on global scale, posing significant threat to public health economic stability. Extensive research has thoroughly explored the molecular mechanisms underlying ischemic stroke, elucidating strong association between soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein receptor proteins (SNAREs) pathogenesis of this condition. SNAREs, class highly conserved involved in membrane fusion, play crucial role modulating neuronal information transmission promoting myelin formation central nervous system (CNS). Preventing SNARE complex formation, malfunctions SNARE-dependent exocytosis, altered regulation SNARE-mediated vesicle fusion are linked excitotoxicity, endoplasmic reticulum (ER) stress, programmed cell death (PCD) stroke. However, its remain unclear. This study conducts comprehensive review existing literature proteins, encompassing structure, classification, expression family, as well assembly - disassembly cycle complexes their physiological roles CNS. We examine which SNAREs contribute pathological progression associated risk factors (hypertension, hyperglycemia, dyslipidemia, atherosclerosis). Furthermore, our findings highlight promise viable target for pharmacological interventions treatment

Language: Английский

Citations

0