Medicine in Drug Discovery,
Journal Year:
2024,
Volume and Issue:
24, P. 100197 - 100197
Published: Aug. 23, 2024
GPCRs
are
a
class
of
membrane
proteins
that
essential
to
signal
transduction,
and
this
is
vital
process
in
many
different
physiologies.
The
significant
mortality
rate
widespread
occurrence
stroke
highlight
the
need
accelerate
research
develop
viable
treatment
agents.
A
promising
prospect
for
development
new
approaches
increasing
comprehension
pathophysiology
crucial
roles
played
by
GPCRs.
Because
blood
clot,
glial
cells'
vascular
supply
abruptly
cut
off,
which
sets
off
series
events
include
inflammation
neuronal
damage
ultimately
lead
cell
death.
Numerous
therapeutic
treatments,
including
thrombolytic
agents
like
tissue
plasminogen
activator
urokinase,
have
been
discovered
as
potential
neuroprotective
medicines;
however,
their
use
restricted
because
modest
window.
Accepting
pertinent
factors
ischemic
stroke,
we
explore
medicinal
promise
GPCR-targeted
treatments
shortcomings
ought
be
resolved
order
translate
these
discoveries
clinical
cases.
Frontiers in Neurology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 30, 2024
Background
Ischemic
stroke
(IS)
is
a
global
health
issue
linked
to
lipid
metabolism
and
immune
cell
responses.
This
study
uses
Mendelian
randomization
(MR)
identify
genetic
risk
factors
for
IS
subtypes
using
comprehensive
data
from
lipidomic
profiles.
Methods
We
assessed
susceptibility
across
179
lipids
731
phenotypes
instrumental
variables
(IVs)
recent
genome-wide
association
studies.
A
two-sample
MR
approach
evaluated
correlations,
two-step
mediation
analysis
explored
the
role
of
in
lipid-IS
pathway.
Sensitivity
analyses,
including
MR-Egger
Cochran
Q
tests,
ensured
robust
results.
Results
Genetic
IVs
162
614
were
identified.
Significant
causality
was
found
between
35
large
artery
(LAS),
with
12
as
(sterol
esters,
phosphatidylcholines,
phosphatidylethanolamines)
23
protective
(phosphatidylcholines,
phosphatidylethanolamines,
phosphatidylinositols).
For
small
vessel
(SVS),
8
phosphatidylcholines),
2
(phosphatidylinositol,
sphingomyelin).
cardioembolic
(CS),
factors,
4
factors.
Mediation
revealed
that
CCR2
on
granulocytes,
CD11c
CD62L
+
myeloid
dendritic
cells,
FSC-A
granulocytes
mediated
lipid-immune
cell-LAS
pathway,
while
CD4
activated
regulatory
T
cells
&
secreting
cell-SVS
Conclusion
identifies
links
specific
subtypes,
highlights
cells’
mediation,
suggests
new
therapeutic
targets,
uncovers
drivers.
Medicine in Drug Discovery,
Journal Year:
2024,
Volume and Issue:
24, P. 100197 - 100197
Published: Aug. 23, 2024
GPCRs
are
a
class
of
membrane
proteins
that
essential
to
signal
transduction,
and
this
is
vital
process
in
many
different
physiologies.
The
significant
mortality
rate
widespread
occurrence
stroke
highlight
the
need
accelerate
research
develop
viable
treatment
agents.
A
promising
prospect
for
development
new
approaches
increasing
comprehension
pathophysiology
crucial
roles
played
by
GPCRs.
Because
blood
clot,
glial
cells'
vascular
supply
abruptly
cut
off,
which
sets
off
series
events
include
inflammation
neuronal
damage
ultimately
lead
cell
death.
Numerous
therapeutic
treatments,
including
thrombolytic
agents
like
tissue
plasminogen
activator
urokinase,
have
been
discovered
as
potential
neuroprotective
medicines;
however,
their
use
restricted
because
modest
window.
Accepting
pertinent
factors
ischemic
stroke,
we
explore
medicinal
promise
GPCR-targeted
treatments
shortcomings
ought
be
resolved
order
translate
these
discoveries
clinical
cases.
