Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Language: Английский
Metabolism Open, Journal Year: 2025, Volume and Issue: 25, P. 100347 - 100347
Published: Jan. 9, 2025
The highly nuanced transition from an inflammatory process to tumorigenesis is of great scientific interest. While it well known that environmental stimuli can cause inflammation, less about the oncogenic modifications chronic inflammation in tissue microenvironment bring about, as how these set off pro-tumorigenic processes. It clear no matter where factors come from, maintaining encourages carcinogenesis. In addition encouraging angiogenesis and metastatic processes, sustaining survival proliferation malignant transformed cells, possibly altering efficacy therapeutic agents, negatively regulate antitumoral adaptive innate immune responses. Because has multiple pathways involved metastasis, gained recognition a marker cancer desirable target for therapy. Recent advances our knowledge molecular mechanisms drive cancer's progression demonstrate promotes metastasis while suppressing anti-tumor immunity. many solid tumor types, including breast, lung, liver cancer, stimulates activation oncogenes impairs body's defenses against tumor. Additionally, alters As tactical approach treatment, findings have underscored importance targeting pathways. This review highlights role development focusing on its impact progression, suppression, therapy resistance. examines current anti-inflammatory strategies, NSAIDs, cytokine modulators, STAT3 inhibitors, addressing their potential limitations. emphasizes need further research unravel complex linking identify targets specific subtypes.
Language: Английский
Citations
4
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: March 7, 2025
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis development of tumor. The needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with improved survival outcomes many cancers. In recent years, increasing attention on the TLS tumor microenvironment, TLSs have emerged a novel target for anti-tumor therapy. Excitingly, studies shown contribution to immune responses. However, it unclear how form more effectively defense against through formation. Recent that inflammation plays role Interestingly, also found gut microbiota can regulate occurrence inflammation. Therefore, we here summarize potential effects microbiota- mediated or immunosuppression formation environments. Meanwhile, this review explores manipulate mature regulating microbiota/metabolites associated signal pathways potentially lead next-generation cancer immunotherapy.
Language: Английский
Citations
2
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(11), P. 1006 - 1020
Published: July 5, 2024
The gut microbiome can play a crucial role in hepatocellular carcinoma (HCC) progression through the enterohepatic circulation, primarily acting via metabolic reprogramming and alterations hepatic immune microenvironment triggered by microbe-associated molecular patterns (MAMPs), metabolites, fungi. In addition, shows potential as biomarker for early HCC diagnosis assessing efficacy of immunotherapy unresectable HCC. This review examines how microbiota dysbiosis, with varied functional profiles, contributes to HCCs different etiologies. We discuss therapeutic strategies modulate including diets, antibiotics, probiotics, fecal transplantation, nano-delivery systems, underscore their an adjunctive treatment modality
Language: Английский
Citations
12
Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 361 - 361
Published: Feb. 28, 2025
An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand bacterial changes accompanying PDAC promotion progression stimulated by inflammation fecal transplantation (FMT), we investigated stool 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions KrasG12D, age- sex-matched control that were exposed to inflammatory stimuli obtained from PDAC. Time- inflammatory-dependent composition alterations alpha diversity reduction observed only a Kras mutation developed advanced changes. Stool Actinobacteriota abundance Bifidobacterium abundances increased. In contrast, Firmicutes, Verrucomicrobiota, Spirochaetota, Desulfobacterota, Butyricicoccus, Roseburia, Lachnospiraceae A2, unclassified, Oscillospiraceae unclassified decreased, detection Alloprevotella uncultured was not observed. Furthermore, FMT accelerated tumorigenesis, gradually decreased diversity, changed microbial mutation. Specifically, Actinobacteriota, Faecalibaculum increased, while genera such as Lachnospiraceace A2 ASF356, Desulfovibrionaceace uncultured, Roseburia decreased. conclusion, carcinogenesis presence an oncogenic chronic dynamically pancreas microbiota. particular, decrease bacteria known be involved short-fatty acids production mouse model can used for further research on microbiota-PDAC interactions towards more personalized effective cancer therapies.
Language: Английский
Citations
0
BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 13, 2025
Cancer immunotherapy has achieved unprecedented success in the field of cancer therapy. However, its potential is constrained by a low therapeutic response rate. Tertiary lymphoid structure (TLS) plays crucial role antitumor immunity and associated with good prognosis. Metabolic reprogramming, as hallmark tumor microenvironment, can influence promote formation follicular helper T cells germinal centers. many current studies focus on correlation between metabolism TLS factors, there insufficient direct evidence to suggest that drives formation. This review provided comprehensive summary relationship formation, highlighting glucose metabolism, lipid amino acid vitamin metabolism. In future, an in-depth exploration how affects cell interactions microorganisms will significantly advance our understanding metabolism-enhanced immunity.
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 17, 2025
Intratumoral microbiota has been found to be a crucial component of hepatocellular carcinoma (HCC). Due insufficient recognition, technical limitations, and low biomass intratumoral microbiota, it is poorly understood. exhibit significant diversity in HCC tissues. It involved the development through several mechanisms, such as remodeling immunosuppressive microenvironment, metabolic reprogramming, genetic alterations. Moreover, associated with metastasis cells. Herein, we reviewed history applied biotechnology depict signatures investigated potential sources assessed their functions, heterogeneity. Furthermore, this review, summarized therapeutics that can used treatment proposed future perspectives for research field.
Language: Английский
Citations
0
Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4058 - 4058
Published: Dec. 16, 2024
Hyperlipidemia poses significant risks for cardiovascular diseases, with emerging evidence underscoring the critical role of gut microbiota in metabolic regulation. This study explores Lactobacillus casei CAAS36, a probiotic strain promising cholesterol-lowering capabilities, assessing its impact on hyperlipidemic hamsters. Utilizing 1H NMR-based metabolomics and 16S rRNA gene sequencing, we observed that L. CAAS36 treatment not only altered pathways but also reshaped composition. Notably, restored balance between Firmicutes Bacteroidetes significantly increased abundance propionate-producing Muribaculaceae. Metabolically, administration led to normalization key lipid markers, including reductions total cholesterol, LDL-C, triglycerides (29.9%, 29.4% 32.6%), while enhancing protective HDL-C levels. These effects were accompanied by increases beneficial metabolites such as propionate succinate, which are known their roles preventing disorders. findings highlight dual regulatory profile microbiota, suggesting substantial potential this management hyperlipidemia possibly other diseases. Future applications may include use natural therapeutic agent clinical settings, aiming reduce reliance conventional pharmaceuticals associated side effects.
Language: Английский
Citations
2
Head & Neck, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 12, 2024
Abstract Background Effective biomarkers for assessing anti‐PD‐1/PD‐L1 therapy efficacy in patients with nasopharyngeal carcinoma (NPC) are still lacking. The human gut microbiota has been shown to influence clinical response many cancers. However, the relationship between and of immunotherapy not determined. Methods We conducted a prospective study which fecal blood samples from NPC were subjected 16S rDNA sequencing survival analysis. To investigate potential differences microbiome these groups identify indicative efficacy, categorized into two according their immunotherapy, responder group (R group) non‐responder (NR group). Progression‐free (PFS) subgroups was analyzed using Kaplan–Meier analysis log‐rank test. Additionally, we performed univariate multivariate analyses evaluate prognostic factors. Finally, carried out non‐targeted metabolomics examine metabolic effects associated identified microbiome. Results Our results showed that abundance Lachnoclostridium higher NR than R ( p = 0.003), alpha diversity 0.050). Patients lower had better PFS 0.048). Univariate 0.017) 0.040) predictor PFS. Non‐targeted revealed affects through usnic acid. Conclusions High predicts poor prognosis receiving immunotherapy.
Language: Английский
Citations
1
European Journal of Cancer, Journal Year: 2024, Volume and Issue: 213, P. 115084 - 115084
Published: Oct. 24, 2024
Language: Английский
Citations
1
BMC Microbiology, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 19, 2024
Significant gaps exist in understanding the gastrointestinal microbiota patients with pancreatic cancer (PCA) versus benign or low-grade malignant tumors (NPCA). This study aimed to analyze these characteristics and explore their potential use distinguishing lesions. Between September 2020 May 2024, fecal oral samples were collected from 121 undergoing surgical resection diagnostic biopsy of lesions, including 75 PCA 46 NPCA, 16s rRNA sequencing was performed. Random forest models based using data developed diagnose performance assessed leave-one-out cross validation method. The Shannon index PCoA analysis revealed significant differences composition between NPCA (p < 0.001 p = 0.001, respectively). Fecal microbiome richness differed significantly 0.02), though similarity noted 0.238). LEfSe identified 16 23 genera microbiomes, respectively. classifiers on achieved areas under curves (AUCs) 89.4% 96.3%, respectively, for NPCA. In mucinous tumor cohort, outperformed CA19-9, yielding AUCs 83.0% 85.2%, compositions different patients. utilizing effectively distinguish
Language: Английский
Citations
1