A Prediction Model for the Diagnosis of Sepsis Based on the Classification of Acute Gastrointestinal Injury

British Journal of Hospital Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19

Published: May 19, 2025

Aims/Background The existing screening approaches for sepsis demonstrate lower sensitivity, potentially resulting in misdiagnosis of septic conditions. gastrointestinal tract is the primary and most susceptible organ during sepsis. Therefore, this study aims to establish evaluate a predictive model based on classification acute injury (AGI), improve diagnostic sensitivity. Methods This retrospective included patients with confirmed infections or suspected who were admitted general ward Changshu Hospital Affiliated Soochow University (Changshu First People's Hospital, China) between April 2023 December 2023. Patients randomly divided into developing cohort (n = 1667) validation 712) 7:3 ratio. Furthermore, data collected various variables, including inflammatory factors, hemodynamic dysfunction tissue perfusion variables. Univariate analysis was used screen risk factors associated sepsis, logistic regression employed identify independent factors. nomogram constructed these Additionally, prediction significance evaluated using receiver operating characteristic (ROC) curves, calibration decision curve (DCA) across both cohorts. Results Out total 2379 study, rate 12.5%. incidence AGI 96.0%, 23.2% grade I, 52.3% II, 16.1% III, 4.4% IV. Factors like age (Odds Ratio (OR) 1.029, 95% Confidence Interval (CI) 1.015–1.043, p < 0.01), hypotension (OR 3.863, CI 2.372–6.290, oxygen saturation (SpO 2 ) 0.795, 0.751–0.840, thrombocytopenia 5.657, 2.835–11.289, 0.01) 7.151, 5.040–10.144, observed as predictors Based five (model B) developed. Model B achieved area under (AUC) 0.947 (95% 0.932–0.963) 0.962 0.945–0.978) cohorts, respectively, which significantly higher than AUC value quick Sequential Organ Failure Assessment (qSOFA) A). curves datasets close ideal model. Decision revealed that exhibited better net clinical benefit A. Conclusion developed validated novel could predict wards, helping decision-making.

Language: Английский

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Gut microbiota and oral cavity cancer: a two-sample bidirectional Mendelian randomization study

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 30, 2024

This study employs a two-sample bidirectional Mendelian randomization (MR) approach to systematically evaluate the causal relationship between gut microbiota and oral cavity cancer (OCC). Objective To address challenge in establishing OCC, we applied systematic MR analysis. Methods Utilizing GWAS data from MiBioGen consortium (18,340 individuals) UK Biobank (n = 264,137), selected instrumental variables employed MR-Egger, weighted median, IVW, mode analyses. Heterogeneity pleiotropy were assessed using Cochran’s Q test MR-Egger intercept test. Results Our findings indicate, at order level, Bacteroidales (OR 0.9990, 95% CI 0.9980–1.0000, P 0.046 ), Burkholderiales 1.0009, 1.0001–1.0018, 0.033 Victivallales 0.9979, 0.9962–0.9995, 0.037 ) exhibit causality on OCC Weighted analyses, respectively. At family Alcaligenaceae 1.0012, 1.0004–1.0019, 0.002 Clostridiaceae1 0.9970, 0.9948–0.9992, 0.027 show IVW genus Clostridiumsensustricto1 (IVW, OR 0.9987, 0.9980–0.9995, 0.001 ; 0.9978, 0.035 Desulfovibrio 1.0008, 1.0001–1.0015, 0.016 Eggerthella 0.9995, 0.9990–1.0000, 0.048 Eubacterium fissicatena group 1.0005, 1.0000–1.0009, 0.032 Holdemanella 0.9994, 0.9989–0.9999, 0.018 are implicated causing related Conclusion identifies order, family, genus, as causally increasing risk. In contrast, associated with decreased However, further investigations essential delineate an optimal composition unravel underlying mechanisms of specific bacterial taxa pathophysiology.

Language: Английский

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Causal associations between gut microbiota and premature rupture of membranes: a two-sample Mendelian randomization study

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 2, 2024

Background Previous study has indicated a potential link between gut microbiota and maternal pregnancy outcomes. However, the causal relationship premature rupture of membranes (PROM) remains topic ongoing debate. Methods A two-sample Mendelian Randomization (MR) was used to investigate PROM. Genetic data on obtained from MiBioGen consortium’s largest genome-wide association (GWAS) (n=14,306). PROM (3011 cases 104247 controls) were sourced publicly available GWAS Finnish National Biobank FinnGen consortium. Various methods including Inverse variance weighted (IVW), MR-Egger, simple mode, median, mode utilized assess by calculating odd ratio (OR) value confidence interval (CI). Sensitivity analyses for quality control performed using MR-Egger intercept tests, Cochran’s Q leave-one-out analyses. Results The IVW method revealed that class Mollicutes (IVW, OR=0.773, 95%CI: 0.61-0.981, pval = 0.034), genus Marvinbryantia OR=00.736, 0.555-0.977, Ruminooccaceae UCG003 OR=0.734, 0.568-0.947, 0.017) phylum Tenericutes 0.566-1.067, 0.034) associated with reduced risk PROM, while Collinsella OR=1.444, 1.028-2.026, Intestinibacter OR=1.304, 1.047-1.623, 0.018) Turicibacter OR=1.282, 1.02-1.611, 0.033) increased Based other four supplementary methods, six may have effect Due presence pleiotropy ( =0.045), Lachnoclostridium should be ruled out. No evidence horizontal or heterogeneity found in &gt; 0.05). Conclusions In this study, we discovered specific probiotics pathogens host identification through MR studies offers novel approach diagnosing treating condition, thereby providing new strategy clinically preventing

Language: Английский

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Muramyl dipeptide potentiates Staphylococcus aureus lipoteichoic acid-induced nitric oxide production via TLR2/NOD2/PAFR signaling pathways

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Lipoteichoic acid (LTA) and peptidoglycan (PGN) are considered as key virulence factors of

Language: Английский

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脓毒症免疫抑制与肠道菌群失调

Scientia Sinica Vitae, Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

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Causal effect of gut microbiota on venous thromboembolism: a two-sample mendelian randomization study

Thrombosis Journal, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 29, 2024

The gut microbiota of venous thromboembolism (VTE) patients exhibited significant alterations. However, the causal relationship between and VTE has not been fully understood. This study aimed to assess risk using a two-sample Mendelian Randomization (MR) study. genetic data were collected from MiBioGen consortium UK biobank, respectively. potential was investigated MR analysis, including inverse variance weighted (IVW), median, MR-Egger, simple mode, mode methods. Cochran's Q-test, MR-PRESSO, MR-Egger regression intercept analysis utilized perform sensitivity analysis. At genus level, results found that Coprococcus1 (OR: 1.0029, 95% CI: 1.0005–1.0054, p = 0.0202) suggestively linked with an increased VTE, while Slackia (odds ratio (OR): 0.9977, confidence interval (CI): 0.9957–0.9998, 0.0298), Butyricicoccus 0.9971, 0.9945–0.9997, 0.0309), Eubacterium coprostanoligenes group 0.9972, 0.9946–0.9999, 0.0445), Bacteroides 0.9964, 0.9932–0.9995, 0.0234) associated reduced VTE. No heterogeneity horizontal pleiotropy detected. there relationships five Our findings may provide new insights into mechanisms

Language: Английский

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