Attribution of psychiatric manifestations to systemic lupus erythematosus in Chinese patients: A retrospective study

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(2)

Published: Jan. 14, 2025

BACKGROUND Not all neuropsychiatric (NP) manifestations in patients with systemic lupus erythematosus (SLE) are secondary to lupus. The clarification of the cause NP symptoms influences therapeutic strategies for SLE. AIM To understand attribution psychiatric a cohort Chinese METHODS This retrospective single-center study analyzed 160 inpatient medical records. Clinical diagnosis, which is considered gold standard, was used divide subjects into SLE (PSLE) group (G1) and (G2). features were compared between these two groups. sensitivity specificity Italian model explored. RESULTS A total 171 syndromes recorded 138 patients, including 87 cases acute confusional state, 40 cognitive dysfunction, 18 psychosis, 13 each depressive disorder mania or hypomania. 141 (82.5%) attributed In contrast G2 G1 had higher Disease Activity Index-2000 scores (21 vs 12, P = 0.001), lower prevalence anti-beta-2-glycoprotein 1 antibodies (8.6% 25.9%, 0.036), anti-ribosomal ribonucleoprotein particle (rRNP) (39.0% 22.2%, 0.045). exhibited 95.0% 70.0% when threshold value set at 7. CONCLUSION Patients PSLE increased disease activity. There correlation anti-rRNP antibodies. effectively assesses multiple who present symptoms.

Language: Английский

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Bipolar Disorder Associated With Systemic Lupus Erythematosus: A Case–Control Study in the All of Us Research Program

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(3)

Published: March 1, 2025

Language: Английский

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Bioinformatic analysis and experimental verification reveal expansion of monocyte subsets with an interferon signature in systemic lupus erythematosus patients

Arthritis Research & Therapy, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 25, 2025

Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by chronic inflammation and multi-organ damage. A central factor in SLE pathogenesis the excessive production of type I interferon (IFN-I), which drives immune dysregulation. Monocytes, key components system, significantly contribute to IFN-I production. However, their specific roles remain incompletely understood. This study utilized bioinformatics statistical analyses, including robust rank aggregation (RRA), DESeq2, limma, analyze transcriptome data from peripheral blood mononuclear cells (PBMCs) monocytes patients healthy controls. Single-cell RNA sequencing (scRNA-seq) were processed using Seurat R package identify characterize monocyte subsets with strong IFN-driven gene signature. Flow cytometry was employed validate findings, markers such as CD14, SIGLEC1, IRF7 confirm subset composition. Our research has found that undergo transcriptional reprogramming, upregulation signature genes (ISGs), forming SLE-Related Monocyte Signature (SLERRAsignature). Moreover, composition phagocyte changes, an increase trend proportion CD14Mono8 flare group. The differentially expressed (DEGs) 13 are mainly ISGs, expression ISGs higher severe patients. We identified SIGLEC1+IRF7+ among these for first time discovered this group individuals. In SLE, enrichment score set representing positively correlated severity SLE. Finally, flow confirmed frequency CD14+SIGLEC1+IRF7+ PBMCs compared expansion IFN-I-producing subsets, particularly subset, plays crucial role pathogenesis. may serve potential biomarker therapeutic target managing

Language: Английский

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Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the Potential to Prevent or Correct Dysregulation of Systems during Aging and in Disease

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 905 - 905

Published: July 25, 2024

Lithium is one of the lightest elements on Earth and it has been in environment since formation galaxy. While a common element, not found to be an essential element biological processes, ranging from single cell organisms Homo sapiens. Instead, at early stage evolution, committed range such as sodium, potassium, calcium, magnesium, zinc, iron serve functions. Such ions critical functions ion channels, co-factors enzymes, cofactor oxygen transport, DNA replication, storage molecule bone liver, variety other roles processes. seemingly excluded major role lithium appear able modulate processes “correct” deviation normal activity, deficiency can have consequences. salts are low levels many foods water supplies, but effectiveness Li affect systems came recent prominence with work Cade, who reported that administrating calmed guinea pigs was subsequently effective relatively high doses “normalize” subset patients bipolar disorders. Because its ability pathways (e.g., cyclic AMP, GSK-3beta, inositol metabolism, NaK ATPases, neuro centers, immune-related events, respectively) both vitro vivo during development adult life, become useful tool better understand molecular regulation also provide insights into altered aging disease states. targets for action supports possible modulator dysregulation, presents conundrum researchers attempting elucidate specific primary target different tissues vivo. This review will discuss aspects state knowledge regarding some influenced, focusing those involving neural autoimmunity examples, mechanisms involved, examples how used study model systems, well suggesting areas where use could lead additional natural levels. In addition, caveats used, strengths weaknesses rodent models, background genetics strain mice or rats employed, sex animals cells discussed. Low-dose may excellent potential, alone combination interventions prevent alleviate aging-associated conditions progression.

Language: Английский

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Correlation between neuropsychiatric systemic lupus erythematosus and immunological markers: a real-world retrospective study

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(9), P. 2833 - 2842

Published: July 12, 2024

Language: Английский

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Significance of Autoantibodies

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 43

Published: Jan. 1, 2024

Language: Английский

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Significance of Autoantibodies

Published: Jan. 1, 2024

Language: Английский

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