The Interplay between Liver and Adipose Tissue in the Onset of Liver Diseases: Exploring the Role of Vitamin Deficiency DOI Creative Commons
Ivan Tattoli, Aimee Rachel Mathew, Antonella Verrienti

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1631 - 1631

Published: Sept. 30, 2024

The deficiency of vitamins, a condition known as “hidden hunger”, causes comprehensive pathological states. Research over the years has identified relationship between liver diseases and hypovitaminosis or defects in vitamin metabolism. exact mechanisms remain elusive; however, crucial involvement specific vitamins metabolic functions, alongside reclassification disease dysfunction-associated steatotic (MASLD), prompted researchers to investigate potential cause-effect dynamics disease. Moreover, scientists are increasingly investigating how might disrupt organ crosstalk, potentially contributing Although concept dysmetabolic circuit linking adipose tissue liver, leading disease, been discussed, possible this axis is relatively recent area study, with numerous critical aspects yet be fully understood. In review, we examine research from 2019 July 2024 focusing on link liver-adipose crosstalk involved onset progression non-alcoholic fatty (NAFLD). Studies report that can affect axis, mainly affecting regulation systemic energy balance inflammation.

Language: Английский

Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay DOI Open Access
Konstantinos Arvanitakis, Elena Chatzikalil, Georgios Kalopitas

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4243 - 4243

Published: July 20, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) are prevalent conditions that have been correlated with infertility through overlapped pathophysiological mechanisms. MASLD is associated metabolic considered among the major causes of chronic disease, while PCOS, which characterized by ovulatory dysfunction hyperandrogenism, one leading female infertility. The links between PCOS not yet fully elucidated, insulin resistance, hyperandrogenemia, obesity, dyslipidemia being key pathways contribute to lipid accumulation, inflammation, fibrosis, aggravating dysfunction. On other hand, exacerbates resistance dysregulation in women creating a vicious cycle progression. Understanding intricate relationship crucial improving clinical management, collaborative efforts different medical specialties essential optimize fertility health outcomes individuals PCOS. In this review, we summarize complex interplay highlighting importance increasing attention prevention, diagnosis, treatment both entities.

Language: Английский

Citations

4
Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis DOI
Esma Konuk, Ertan Katırcı, Mehmet Şimşek

et al.

Histochemistry and Cell Biology, Journal Year: 2025, Volume and Issue: 163(1)

Published: Jan. 29, 2025

Language: Английский

Citations

0
Gegen-Qinlian Decoction Alleviates Metabolic Dysfunction-Associated Steatohepatitis by Modulating the Microbiota-Bile Acid Axis in Mice DOI

Xiangbing Shu,

Ying Cao,

Yan Wu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
MYCBP2-mediated HNF4α ubiquitination reprogrammed lipid metabolism in MASH-associated hepatocellular carcinoma DOI
Hao Zhang,

Xiangxu Kong,

Haoran Qu

et al.

Oncogene, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Language: Английский

Citations

0
Gegen-Qinlian decoction alleviates metabolic dysfunction-associated steatohepatitis by modulating the microbiota-bile acid axis in mice DOI

Xiangbing Shu,

Ying Cao,

Yan Wu

et al.

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119719 - 119719

Published: April 1, 2025

Language: Английский

Citations

0
Targeting Metabolism: Innovative Therapies for MASLD Unveiled DOI Open Access
Weixin Wang, Xin Gao, Wei Niu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4077 - 4077

Published: April 25, 2025

The recent introduction of the term metabolic-dysfunction-associated steatotic liver disease (MASLD) has highlighted critical role metabolism in disease’s pathophysiology. This innovative nomenclature signifies a shift from previous designation non-alcoholic fatty (NAFLD), emphasizing condition’s progressive nature. Simultaneously, MASLD become one most prevalent diseases worldwide, highlighting urgent need for research to elucidate its etiology and develop effective treatment strategies. review examines delineates revised definition MASLD, exploring epidemiology pathological changes occurring at various stages disease. Additionally, it identifies metabolically relevant targets within provides summary latest targeted drugs under development, including those clinical some preclinical stages. finishes with look ahead future therapy goal summarizing providing fresh ideas insights.

Language: Английский

Citations

0
MRTO4 Enhances Glycolysis to Facilitate HCC Progression by Inhibiting ALDOB DOI Creative Commons

Yongyuan Zheng,

Yansong Huang,

Weibing Li

et al.

Medical Science Monitor, Journal Year: 2024, Volume and Issue: 30

Published: May 15, 2024

Background:MRT4 Homolog, Ribosome Maturation Factor (MRTO4) is often upregulated in cancer cells.However, its impact hepatocellular carcinoma (HCC) less well understood.Herein, we explored the prognostic and energy metabolism reprogramming role of MRTO4 HCC. Material/Methods:Clinical data were obtained from The Cancer Genome Atlas (TCGA), expression clinical samples was analyzed.The association between different variables overall survival (OS) studied, as their potential independent factors, using Cox regression analysis.We constructed a nomogram including pathological to provide predictive model for prognosis.Heatmaps, Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) analysis revealed relationship pathways MRTO4.We used classic molecular biology research methods, RT-qPCR, Western blotting, CCK8, TUNEL, Clone formation, Transwell assay, ELISA, immunohistochemistry, study promoting progression HCC through glycolysis regulation. Results:Our showed that an risk factor accelerates cells, promotes proliferation invasion, suppresses apoptosis cells.The underlying mechanism involves accelerating by inhibiting ALDOB. Conclusions:Our novel which progression, suggests could be therapeutic strategy

Language: Английский

Citations

2
Could Gas6/TAM Axis Provide Valuable Insights into the Pathogenesis of Systemic Sclerosis? DOI Creative Commons
Daria Apostolo, Davide D’Onghia, Alessandra Nerviani

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 7486 - 7504

Published: July 15, 2024

Systemic sclerosis (SSc) is a connective tissue disorder characterized by microvascular injury, extracellular matrix deposition, autoimmunity, inflammation, and fibrosis. The clinical complexity high heterogeneity of the disease make discovery potential therapeutic targets difficult. However, recent progress in comprehension its pathogenesis encouraging. Growth Arrest-Specific 6 (Gas6) Tyro3, Axl, MerTK (TAM) receptors are involved multiple biological processes, including modulation immune response, phagocytosis, apoptosis, fibrosis, cancer development, autoimmune disorders. In present manuscript, we review current evidence regarding SSc role Gas6/TAM system several human diseases, suggesting likely contribution highlighting areas where further research necessary to fully comprehend TAM this condition. Indeed, understanding involvement SSc, which currently unknown, could provide valuable insights for novel targets.

Language: Английский

Citations

1
Rifaximin prophylaxis in MASLD‑hepatocellular carcinoma: Lessons from a negative animal model DOI Open Access
Larisse Longo, Gabriel Tayguara Silveira Guerreiro, Luiza Marques Prates Behrens

et al.

Biomedical Reports, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 24, 2024

The incidence of hepatocellular carcinoma (HCC) has been rising, particularly among individuals diagnosed with metabolic dysfunction-associated steatotic liver disease. In the present study, prophylactic effects rifaximin (RIF) on HCC, inflammatory markers and cardiovascular risk (CVR) were investigated in an animal model. Adult Sprague-Dawley rats randomly allocated into three groups (n=10, each): Control [standard diet/water plus gavage vehicle (Veh)], HCC [high-fat choline deficient diet (HFCD)/diethylnitrosamine (DEN) drinking water/Veh gavage] RIF [HFCD/DEN/RIF (50 mg/kg/day) groups. After euthanasia at week 16, biochemical/inflammatory histology assessed. results demonstrated that animals had a significant increase fresh weight, weight/body weight ratio, serum total cholesterol (TC), high-density lipoprotein-cholesterol, triglycerides, hepatic lipid accumulation concentration triglycerides TC, relative to controls (P<0.001, for all). Additionally, higher plasminogen activator inhibitor, intercellular adhesion molecule-1, E-selectin CVR scores than interleukin (IL)-1β (P=0.011), IL-10 (P<0.001), toll-like receptor-2 (P=0.012), lipopolysaccharide-binding protein (P=0.018) metalloproteinase-2 (P=0.003) levels animals. Furthermore, steatosis, inflammation fibrosis, along increased collagen fiber deposition occurred However, only 2 rats. conclusion, although most did not develop positively affected involved steatohepatitis pathogenesis.

Language: Английский

Citations

0
The Interplay between Liver and Adipose Tissue in the Onset of Liver Diseases: Exploring the Role of Vitamin Deficiency DOI Creative Commons
Ivan Tattoli, Aimee Rachel Mathew, Antonella Verrienti

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1631 - 1631

Published: Sept. 30, 2024

The deficiency of vitamins, a condition known as “hidden hunger”, causes comprehensive pathological states. Research over the years has identified relationship between liver diseases and hypovitaminosis or defects in vitamin metabolism. exact mechanisms remain elusive; however, crucial involvement specific vitamins metabolic functions, alongside reclassification disease dysfunction-associated steatotic (MASLD), prompted researchers to investigate potential cause-effect dynamics disease. Moreover, scientists are increasingly investigating how might disrupt organ crosstalk, potentially contributing Although concept dysmetabolic circuit linking adipose tissue liver, leading disease, been discussed, possible this axis is relatively recent area study, with numerous critical aspects yet be fully understood. In review, we examine research from 2019 July 2024 focusing on link liver-adipose crosstalk involved onset progression non-alcoholic fatty (NAFLD). Studies report that can affect axis, mainly affecting regulation systemic energy balance inflammation.

Language: Английский

Citations

0