ONCOLOGIE,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 5, 2024
Abstract
Photodynamic
therapy
(PDT)
using
5-aminolevulinic
acid
(5-ALA)
has
emerged
as
a
promising
strategy
in
the
treatment
of
various
cancers,
particularly
gliomas.
The
biosynthesis
prodrug
5-ALA
plays
pivotal
role
heme
production
pathway
Protoporphyrin
IX
(PpIX),
and
understanding
this
molecular
process
offers
significant
insights
into
cellular
physiology
therapeutic
potential.
This
review
highlights
clinical
applications
PDT,
underscoring
translational
impact
foundational
research
on
its
biosynthesis.
search,
performed
PubMed
Web
Science,
included
both
vivo
studies
vitro
preclinical
studies.
findings
emphasize
expanding
potential
for
novel
strategies,
driven
by
an
enhanced
application
offering
future
medical
advancements
cancer
treatment.
Biological Procedures Online,
Journal Year:
2024,
Volume and Issue:
26(1)
Published: Aug. 17, 2024
Oral
cancers,
specifically
oral
squamous
cell
carcinoma
(OSCC),
pose
a
significant
global
health
challenge,
with
high
incidence
and
mortality
rates.
Conventional
treatments
such
as
surgery,
radiotherapy,
chemotherapy
have
limited
effectiveness
can
result
in
adverse
reactions.
However,
an
alternative,
photodynamic
therapy
(PDT)
has
emerged
promising
option
for
treating
cancers.
PDT
involves
using
photosensitizing
agents
conjunction
specific
light
to
target
destroy
cancer
cells
selectively.
The
photosensitizers
accumulate
the
generate
reactive
oxygen
species
(ROS)
upon
exposure
activating
light,
leading
cellular
damage
ultimately
death.
offers
several
advantages,
including
its
non-invasive
nature,
absence
of
known
long-term
side
effects
when
administered
correctly,
cost-effectiveness.
It
be
employed
primary
treatment
early-stage
cancers
or
combination
other
therapies
more
advanced
cases.
Nonetheless,
it
is
important
note
that
most
effective
superficial
localized
may
not
suitable
larger
deeply
infiltrating
tumors.
Light
sensitivity
temporary
occur
but
managed
appropriate
care.
Ongoing
research
endeavors
aim
expand
applications
develop
novel
further
enhance
efficacy
treatment.
This
review
aims
evaluate
by
analyzing
preclinical
clinical
studies.
Nanoenergy Advances,
Journal Year:
2025,
Volume and Issue:
5(2), P. 4 - 4
Published: March 31, 2025
Nowadays,
due
to
improvements
in
living
standards,
more
attention
is
reserved
all-around
disease
prevention
and
health
care.
In
particular,
research
efforts
have
been
made
for
developing
novel
methods
treatments
anti-cancer
therapy.
Self-powered
nanogenerators
emerged
recent
years
as
an
attractive
cost-effective
technology
harvest
energy
or
biosensing
applications.
Bioelectronic
can
be
used
inducing
tissue
recovery
treating
human
illness
through
electrical
stimulation.
However,
there
still
a
lack
of
comprehensive
cognitive
assessment
these
devices
platforms,
especially
regarding
which
requirements
must
satisfied
working
principles
transduction
adopted
effectively
the
body.
This
review
covers
most
advances
bioelectronic
therapy,
based
on
different
transducing
strategies
(photodynamic
drug
delivery,
stimulation,
atomic
nanogenerators,
etc.),
potential
mechanisms
repair
promotion
are
discussed.
The
prospective
challenges
finally
summarized
with
indication
future
outlook.
Photochemistry and Photobiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 13, 2025
Abstract
The
setups
of
previous
and
ongoing
clinical
trials
are
based
on
prescribed
PDT
doses,
PS
concentration,
light
intensity
derived
from
averages
or
study
populations.
It
is
understood
that
monitoring
personalized
dose
needed
to
improve
outcomes.
Monitoring
photophysical,
photochemical,
cytotoxic
moieties
common,
representing
concepts
delivered,
absorbed,
equivalent
doses
similar
those
used
in
radiation
therapy
(RT).
Unlike
RT,
these
not
equally
well
developed
standardized
across
the
indications;
however,
there
potential
treatment
setup,
planning,
delivery
by
leveraging
methodologies
RT.
This
review
summarizes
definitions
advancements
RT
planning
presents
for
PDT,
particularly
how
can
expand
existing
methods
planning.
By
identifying
major
limitations
areas
improvement
hope
stimulate
preclinical
research
studies
enhance
efficacy
improving
patient
Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 28, 2024
Abstract
Lung
cancer,
a
highly
prevalent
and
lethal
form
of
is
often
associated
with
oxidative
stress.
Photodynamic
therapy
(PDT)
has
emerged
as
promising
alternative
therapeutic
tool
in
cancer
treatments,
but
its
efficacy
closely
correlated
to
the
photosensitizers
generating
reactive
oxygen
species
(ROS)
antioxidant
capacity
tumor
cells.
In
particular,
glutathione
(GSH)
can
reduce
ROS
thus
compromise
PDT
efficacy.
this
study,
GSH‐responsive
near‐infrared
photosensitizer
(TBPPN)
based
on
aggregation‐induced
emission
for
real‐time
monitoring
GSH
levels
enhanced
lung
treatment
developed.
The
strategic
design
TBPPN,
consisting
donor–acceptor
structure
incorporation
dinitrobenzene,
enables
dual
functionality
by
not
only
fluorescence
being
activated
also
depleting
enhance
cytotoxic
effect
PDT.
TBPPN
demonstrates
synergistic
vitro
against
A549
cells
specifically
targeting
different
cellular
compartments
intracellular
GSH.
vivo
studies
further
confirm
that
effectively
inhibit
growth
mouse
model
highlighting
potential
an
integrated
agent
diagnosis
cancer.
This
approach
enhances
effectiveness
deserves
exploration
clinical
application.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
The
convergence
of
nanotechnology
and
cancer
therapeutics
has
opened
new
frontiers
in
the
development
advanced
drug
delivery
systems.
Among
various
nanocarriers,
nanobubbles
offer
significant
potential
due
to
their
unique
properties,
such
as
high
payload
capacity,
responsiveness
external
stimuli
like
ultrasound,
enhanced
permeability
retention
(EPR)
effects.
Functionalizing
these
with
chitosan,
a
naturally
derived
biopolymer
known
for
its
biocompatibility,
biodegradability,
ability
enhance
cellular
uptake,
further
improves
therapeutic
efficacy.
This
review
provides
comprehensive
analysis
synthesis,
functionalization,
application
chitosan-functionalized
therapy.
We
discuss
mechanism
action,
including
targeted
delivery,
ultrasound-mediated
release,
immune
modulation,
alongside
recent
advancements
challenges
clinical
translation.
also
explores
future
directions
this
rapidly
evolving
field,
aiming
insights
into
next-generation
therapeutics.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2141 - 2141
Published: Sept. 20, 2024
This
preclinical
study
was
conducted
to
investigate
the
efficacy
of
interstitial
PDT
(i-PDT)
for
malignant
gliomas
arising
deep
within
brain,
which
are
difficult
remove.
C6
glioma
cells
were
implanted
into
basal
ganglia
rats,
and
3
weeks
later,
second-generation
photosensitizer
talaporfin
sodium
(TPS)
administered
intraperitoneally.
Ninety
minutes
after
administration,
a
prototype
fine
plastic
optical
fiber
punctured
tumor
tissue,
semiconductor
laser
light
irradiated
from
2-mm
cylindrical
light-emitting
source
under
various
conditions.
The
brain
removed
24
h
i-PDT
analyzed
pathologically.
able
puncture
center
in
all
cases,
enabling
be
performed.
Histological
analysis
showed
that
necrosis
induced
areas
close
source,
correlating
with
irradiation
energy
dose,
whereas
apoptosis
at
some
distance
source.
Irradiation
using
high
levels
resulted
tissue
swelling
strong
necrosis,
75
J/cm2
most
suitable
inducing
apoptosis.
An
experimental
system
TPS
established
transplanted
rat
brain.
Tumor
cell
death,
correlated
propagation,
tissue.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 22, 2024
Immunotherapy
has
emerged
as
a
promising
avenue
for
cancer
treatment
by
bolstering
the
immune
system's
ability
to
recognize
and
attack
cells.
Photodynamic
therapy
shows
potential
in
enhancing
antitumor
immunity,
though
mechanisms
behind
its
success
are
not
fully
understood.
In
this
manuscript,
we
investigate
two
previously
reported
green
light
activated
PCT/PDT
agents
where
compound
