Cells, Journal Year: 2024, Volume and Issue: 13(20), P. 1678 - 1678
Published: Oct. 11, 2024
This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, known MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility, limiting its bio-distribution therapeutic efficacy. The potential nutlin-3a-loaded was investigated on two in vitro models melanoma: HT144 cell line
Language: Английский
Cancers, Journal Year: 2024, Volume and Issue: 16(12), P. 2262 - 2262
Published: June 18, 2024
Melanoma, originating through malignant transformation of melanin-producing melanocytes, is a formidable malignancy, characterized by local invasiveness, recurrence, early metastasis, resistance to therapy, and high mortality rate. This review discusses etiologic risk factors for melanoma, diagnostic prognostic tools, including recent advances in molecular biology, omics, bioinformatics, provides an overview its therapy. Since the incidence melanoma rising remains unacceptably high, we discuss inherent properties, melanogenesis, that make this disease resilient treatment propose use AI solve above complex multidimensional problems. We provide on vitamin D anticancerogenic report field can solutions prevention and/or therapy melanoma. Experimental papers clinicopathological studies role status signaling pathways initiated active metabolites prognosis are reviewed. conclude signaling, defined specific nuclear receptors selective activation hydroxyderivatives, benefit new or existing therapeutic approaches. target with computational biology tools solution problem.
Language: Английский
Citations
20
Archives of Dermatological Research, Journal Year: 2025, Volume and Issue: 317(1)
Published: Jan. 16, 2025
Language: Английский
Citations
0
Tissue and Cell, Journal Year: 2025, Volume and Issue: 93, P. 102753 - 102753
Published: Jan. 20, 2025
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(3), P. 361 - 361
Published: March 12, 2025
Background: Melanoma is one of the most common malignancies, posing a significant health threat to patients, particularly in advanced stages due its high aggressiveness. Chemotherapy agents with biocompatibility and low susceptibility induce resistance are required for systematic management. Methods: Dendrimer-derived mimics (DMs) host defense peptides (HDPs), which were constructed by dendrimer core optimized ratios hydrophobic arm, used treat A375 cells HaCaT as control. Live/dead staining, flow cytometry, scanning electron microscopy (SEM) conducted analyze anticancer mechanism. Mice subcutaneous tumors test antitumor activity toxicity vivo. Results: DMs exhibited enhanced against remarkable selectivity, action natural HDPs can cause damage cell membranes. effectively inhibit solid tumor growth minimal systemic no adverse effects on healthy tissues. Conclusion: All findings highlight promising candidates potential melanoma therapy.
Language: Английский
Citations
0
Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Language: Английский
Citations
0
Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(4), P. e010352 - e010352
Published: April 1, 2025
Background Neural crest-associated genes play pivotal roles in tumor initiation, progression, and the intricate dynamics of microenvironment (TME). Myeloid-derived suppressor cells (MDSC) within TME are important dampening T cell activity contributing to resistance against immunotherapeutic interventions. The neural gene Forkhead Box D1 (FOXD1) has been identified as an oncogenic factor that induces melanoma dedifferentiation progression. However, underlying mechanisms impact FOXD1 on antitumor immune response remain unclear. Methods To investigate impacts microenvironment, we analyzed publicly available datasets from multiple platforms, including TNMplot, TIMER2.0, etc. In addition, was overexpressed (OE) or knocked down identify its biological functions vitro vivo. Flow cytometry arginase assay were used analyze phenotype function MDSC. Western blot, reverse transcription-PCR, ELISA assays employed expression downstream effectors. vivo experiments conducted role progression influence MDSC accumulation TME. Results We demonstrate increased levels inversely correlated with responsiveness immunotherapy. Ex-vivo analyses unveiled monocytes, exposed conditioned medium FOXD1-OE cells, effectively suppressed proliferation upregulated programmed death-ligand 1 (PD-L1) other immunosuppressive factors. a direct regulator interleukin 6 (IL6) expression, which is for induction. Blocking IL6 reversed MDSC-associated immunosuppression. Additionally, miR-581, potential negative FOXD1, attenuated differentiation. demonstrated tumors derived OE contained significantly higher frequency PD-L1 + compared controls, while knockdown resulted reduced growth diminished accumulation. Conclusion Our study elucidated novel pathogenesis, highlighting orchestrating by promoting generation via upregulation.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 22, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 22, 2025
Eph/ephrin signaling, a complex network of cell-cell interactions, plays pivotal role in regulating various biological processes, including cell migration, proliferation, and adhesion. Dysregulation this signaling pathway has been implicated types cancer. In skin cancers such as squamous carcinoma, basal malignant melanoma, promotes tumor invasion metastasis. Aberrant expression Eph receptors ephrin ligands can lead to increased motility, reduced adhesion, enhanced angiogenesis. Furthermore, significantly impact the microenvironment by modulating infiltration activation immune cells, particularly T cells. Dysregulated impair surveillance mechanisms, leading evasion progression. For instance, certain inhibit T-cell promote immunosuppressive conditions within microenvironment. Targeting offers promising therapeutic approach combating cancer By disrupting these pathways, invasion, angiogenesis, be inhibited. This could improved outcomes for patients with
Language: Английский
Citations
0
Journal of Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 3, 2025
Language: Английский
Citations
0
Photochemistry and Photobiology, Journal Year: 2024, Volume and Issue: 100(4), P. 910 - 922
Published: April 16, 2024
Abstract Metastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates. Despite the clinical success of recent immunotherapy approaches, prevailing resistance rates necessitate continued development novel therapeutic options. Photoimmunotherapy (PIT) emerging as a promising strategy that uses photodynamic therapy (PDT) to unleash systemic immune responses against tumor sites while maintaining superior tumor‐specificity minimally invasive nature traditional PDT. In this review, we discuss advances in PIT strategies for management using PIT. can strongly induce immunogenic cell death, inviting concomitant application checkpoint blockade or adoptive therapies. also be leveraged selectively remove suppressive populations associated resistance. The modular design combined potential patient‐specific antigen selection drug co‐delivery makes alluring option future personalized care.
Language: Английский
Citations
3