A Review of Recent Progress in the Mechanisms and Effectiveness of Acupuncture for Treating Allergic Rhinitis

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 1 - 10

Published: Jan. 1, 2025

Abstract: This review aims to summarize and evaluate the latest clinical evidence mechanistic studies regarding acupuncture for treatment of allergic rhinitis AR. Compared with traditional medical treatment, has fewer side effects drug dependence, especially those patients who do not respond well become a new hope. By analyzing results from RCTs, systematic reviews, meta-analyses, significant effectiveness in improving AR symptoms is clarified. We explore mechanisms immune regulation, neural modulation, inflammation microbiota assess its efficacy safety. The indicate that significantly alleviates through multiple biological regulatory mechanisms. Future research should further standardize protocols deepen optimize application. Keywords: acupuncture, rhinitis, mechanisms,

Language: Английский

The potential role of nanobodies in asthma therapy

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 20, 2025

Asthma is a chronic inflammatory disease of the airways characterized by bronchoconstriction, airway hyperresponsiveness, and mucus production. The pathophysiology asthma involves complex interplay immune cells mediators, including cytokines, chemokines, other molecules. Despite advances in management, many patients continue to experience symptoms due limitations current therapies. Monoclonal antibodies (mAbs) targeting specific mediators have improved treatment outcomes for some patients, but challenges such as poor tissue penetration high costs remain. Nanobodies (Nbs), novel class single-domain antibodies, offer promising alternative their small size, stability, potential enhanced penetration. This review discusses key involved asthma, treatments, Nbs new therapeutic strategy. We also explore studies innovations nanobody technology.

Language: Английский

Single-Domain Antibodies—Novel Tools to Study and Treat Allergies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7602 - 7602

Published: July 11, 2024

IgE-mediated allergies represent a major health problem in the modern world. Apart from allergen-specific immunotherapy (AIT), only disease-modifying treatment, researchers focus on biologics that target different key molecules such as allergens, IgE, or type 2 cytokines to ameliorate allergic symptoms. Single-domain antibodies, nanobodies, are newcomers biotherapeutics, and their huge potential is being investigated various research fields since discovery 30 years ago. While they dominantly applied for theranostics of cancer treatment infectious diseases, nanobodies have become increasingly substantial allergology over last decade. In this review, we discuss prerequisites consider be important generating useful nanobody-based drug candidates treating allergies. We further summarize available data used allergen monitoring detection probes therapeutic approaches. reflect limitations addressed during development process, vivo half-life immunogenicity. Finally, speculate about novel application formats allergy might future.

Language: Английский