Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9 DOI Creative Commons
Wilson Domingues, Víctor Ângelo Folgosi, Sabri Saeed Sanabani

et al.

Revista do Instituto de Medicina Tropical de São Paulo, Journal Year: 2024, Volume and Issue: 66

Published: Jan. 1, 2024

The human T-cell lymphotropic virus type 1 (HTLV-1) is a single-stranded positive-sense RNA that belongs to the Retroviridae family, genus Deltaretro, and infects approximately five 10 million people worldwide. Although significant number of individuals living with HTLV-1 remain asymptomatic throughout their lives, some develop one or more severe clinical conditions, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), progressive debilitating disease, and/or subtype non-Hodgkin's lymphoma threatening course known adult leukemia/lymphoma (ATLL). Moreover, current therapeutic options are limited focus primarily on treating symptoms controlling viral latency. CRISPR-Cas9 gene editing proposed promising tool address intricate links associated HTLV-1. By targeting silencing key genes during initial infection dysregulating immune signaling pathways, offers potential intervention opportunities. In this review, we editing, well examine primary mechanisms involved in target discuss existing evidence scientific literature.

Language: Английский

Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation DOI Creative Commons

Geneva N. Kwaku,

Kirstine Nolling Jensen, Patricia Simaku

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Microbial pathogens generate extracellular vesicles (EVs) for intercellular communication and quorum sensing. EVs also induce inflammatory pathways within host innate immune cells. We previously demonstrated that secreted by

Language: Английский

Citations

1
Polymorphism detection of catalase-21A\T (rs 7943316) gene in chronic myeloid leukemia patients infected with human herpes virus-7 DOI Creative Commons
Yusur Falah Faraj

Iraqi Journal of Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Abstract: BACKGROUND: Chronic myeloid leukemia (CML) is a type of cancer that originates in hematopoietic stem cells, particularly those develop into cells. A key feature CML the Philadelphia (Ph) chromosome, which produced by reciprocal translocation between chromosome 9 and 22 (designated as t [9;22]). This chromosomal change results creation BCR-ABL1 fusion gene. Several genetic association studies have analyzed link catalase (CAT) C262T variant different cancers, but findings remain controversial. OBJECTIVE: study was aimed to determine CAT-21A\T (rs 7943316) gene polymorphism percentage human herps virus-7 (HHV-7) patients with CML. PATIENTS AND METHODS: case–control included 120 blood specimens enrolled current research, including 40 newly diagnosed 80 treated patients, well 50 collected from persons control group. Sequencing used identify HHV-7 DNA using conventional polymerase chain reaction (PCR). RESULTS: The mean age 48 ± 12.7 years 10.53 years, whereas controls 12.95 years. PCR testing for revealed positive 6 (15%) 19 (23.8%) In contrast, one person group infected HHV-7. difference frequency genotype distribution diagnosed, groups statistically significant. There no correlation infection. New recording bank NCBI American bank. CONCLUSION: acts cofactor pathogenesis development biology Iraqi patients. Polymorphism may play role risky factor idiopathic

Language: Английский

Citations

0
Innate Sensing of Viral Nucleic Acids and Their Use in Antiviral Vaccine Development DOI Creative Commons
Takuji Enya, Susan R. Ross

Vaccines, Journal Year: 2025, Volume and Issue: 13(2), P. 193 - 193

Published: Feb. 16, 2025

Viruses pose a significant threat to humans by causing numerous infectious and potentially fatal diseases. Understanding how the host's innate immune system recognizes viruses is essential understanding pathogenesis ways control viral infection. Innate immunity also plays critical role in shaping adaptive responses induced vaccines. Recently developed adjuvants often include nucleic acids that stimulate pattern recognition receptors which are components of necessary for activating antigen-presentation cells thereby bridging immunity. Therefore, acid sensing cytosolic sensors essential, as it provides potential means developing new vaccine strategies, including effective adjuvants.

Language: Английский

Citations

0
Neurotropic Viruses as Acute and Insidious Drivers of Aging DOI Creative Commons
Angela Rocchi, Hassen S. Wollebo, Kamel Khalili

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(4), P. 514 - 514

Published: April 1, 2025

Aging is the result of various compounding stresses that gradually overcome homeostatic regulation cell, resulting in irreversible damage. This manifests as many acute and chronic conditions, most common which are neurodegeneration dementia. Epidemiological studies have shown significant, strong correlations between viral infection neurodegenerative diseases. review overlays characteristics pathogenesis with hallmarks aging to discuss how active latent viruses contribute aging. Through our contextualization myriad basic science papers, we offer explanations for premature via induction stress response pathways. Viruses induce stresses: dysregulated homeostasis by exogenous proteins overwhelmed protein quality control mechanisms, DNA damage through direct integration epigenetic manipulation, immune-mediated oxidative immune exhaustion, general energy theft amplified an system. Overall, this highlights long-term importance vaccines antivirals addition their benefits.

Language: Английский

Citations

0
STING Promotes the Progression of ADPKD by Regulating Mitochondrial Function, Inflammation, Fibrosis, and Apoptosis DOI Creative Commons
Jiao Wu, Shasha Cheng,

G.H. Lee

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(10), P. 1215 - 1215

Published: Sept. 26, 2024

Autosomal dominant polycystic kidney disease (ADPKD) is a predominant genetic disease, which caused by mutations in PKD genes and associated with DNA damage cystic cells. The intrinsic stimulator of interferon (STING) pathway crucial for recognizing damaged the cytosol, triggering expression inflammatory cytokines to activate defense mechanisms. However, precise roles mechanisms STING ADPKD remain elusive. In this study, we show that

Language: Английский

Citations

2
Autophagy is a promising process for linking inflammation and redox homeostasis in Down syndrome DOI Creative Commons

Xuehai Ma,

Weimin Li,

Jun Ma

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 2, 2024

Trisomy 21, characterized by the presence of an additional chromosome leads to a set clinical features commonly referred as Down syndrome (DS). The pathological phenotypes observed in DS are caused combination factors, such mitochondrial dysfunction, neuroinflammation, oxidative stress, disrupted metabolic patterns, and changes protein homeostasis signal transduction, these factors collectively induce neurological alterations. In DS, triplication 21 micronuclei arising from missegregation chromosomes closely associated with inflammation development redox imbalance. Autophagy, essential biological process that affects cellular homeostasis, is powerful tool facilitate degradation redundant or dysfunctional cytoplasmic components, thereby enabling recycling their constituents. Targeting autophagy has been suggested promising method balance intracellular stress improve dysfunction. this review, we summarize role regulating discuss crosslinks. A comprehensive elucidation roles offers novel insights for therapeutic strategies aimed at aneuploidy-associated diseases.

Language: Английский

Citations

1
Progress of cGAS-STING signaling pathway-based modulation of immune response by traditional Chinese medicine in clinical diseases DOI Creative Commons
Hui Zhi, Hui Fu, Yunxin Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 16, 2024

The cGAS-STING signaling pathway is a critical component of the innate immune response, playing significant role in various diseases. As central element this pathway, STING responds to both endogenous and exogenous DNA stimuli, triggering production interferons pro-inflammatory cytokines enhance defenses against tumors pathogens. However, dysregulated activation implicated pathogenesis multiple diseases, including autoinflammation, viral infections, cancer. Traditional Chinese Medicines (TCMs), which have long history use, been associated with positive effects disease prevention treatment. TCM formulations (e.g., Lingguizhugan Decoction, Yi-Shen-Xie-Zhuo formula) active compounds Glabridin, Ginsenoside Rd) can modulate thereby influencing progression inflammatory, infectious, or oncological This review explores mechanisms by TCMs interact regulate immunity, focusing on their roles infectious malignancies, autoimmune disorders.

Language: Английский

Citations

1
How Does African Swine Fever Virus Evade the cGAS-STING Pathway? DOI Creative Commons

Can Lin,

Chenyang Zhang, Nanhua Chen

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(11), P. 957 - 957

Published: Nov. 2, 2024

African swine fever (ASF), a highly infectious and devastating disease affecting both domestic pigs wild boars, is caused by the virus (ASFV). ASF has resulted in rapid global spread of disease, leading to significant economic losses within industry. A obstacle creation safe effective vaccines existing knowledge gap regarding pathogenesis ASFV its mechanisms immune evasion. The cyclic GMP-AMP synthase (cGAS)-stimulator interferon genes (STING) pathway major mediating type I (IFN) antiviral response against infections diverse classes pathogens that contain DNA or generate their life cycles. To evade host's innate response, encodes many proteins inhibit production IFN antagonizing cGAS-STING signaling pathway. Multiple are involved promoting viral replication protein-protein interaction during infection. protein QP383R could impair function cGAS. EP364R, C129R B175L disturb guanosine monophosphate-adenosine monophosphate (cGAMP). E248R, L83L, MGF505-11L, MGF505-7R, H240R, CD2v, E184L, p17 interfere with STING. MGF360-11L, I215L, DP96R, A151R S273R affect TANK Binding Kinase 1 (TBK1) IκB kinase ε (IKKε). MGF360-14L, M1249L, E120R, S273R, D129L, E301R, MGF505-7R I226R Interferon Regulatory Factor 3 (IRF3). MGF360-12L, MGF505-7R/A528R, UBCv1 A238L nuclear factor kappa B (NF-Κb).

Language: Английский

Citations

0
Autoinflammatory diseases. Part 1: concept, classification, immunobiology, diagnosis DOI Creative Commons
Olha Shvaratska, M.V. Kalichevska,

O.V. Klymenko

et al.

CHILD`S HEALTH, Journal Year: 2024, Volume and Issue: 19(7), P. 470 - 481

Published: Nov. 30, 2024

Systemic autoinflammatory diseases (SAIDs) are a group of inherited monogenic characterized by dysregulated innate immunity leading to excessive activation inflammatory pathways. Recently, some molecular mechanisms typical for autoinflammation have also been recognized in the pathogenesis several autoimmune and immunodeficiency states. This scientific review aimed systematize current ideas about increase medical professionals’ awareness regarding issue, which is significantly lower than that other categories immune dysfunction. We performed focused search over Web Science, Scopus, PubMed Central®, Google Scholar databases past 10 years using keywords “autoinflammatory diseases”, syndromes”, “autoinflammation”. The reflects historical evolution views on immunopathogenesis since introduction concept 1999: from interleukin (IL)-1-centered paradigm recognition significant role signaling Further, we discuss place spectrum immunological disorders present data immunobiological basis autoinflammation. In particular, how system triggers inflammation within inflammasome, interferon nuclear factor kappa B ­(NF-κB) pathways, highlighting intracellular sensor proteins, inflammasomes, gasdermin D, IL-1β, IL-18 IL-36, ­NF-κB, tumor necrosis factor, type 1 interferons, others. Based underlying pathogenesis, following classification SAIDs suggested recently: inflammasomopathies enhanced IL-1 syndromes, interferonopathies, relopathies, protein misfolding diseases/endoplasmic reticulum stress cytokine-signaling complementopathies. discusses diagnostic challen­ges presents recommendations diagnosis SAIDs, distinguishing features classic existing potential tests.

Language: Английский

Citations

0
Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9 DOI Creative Commons
Wilson Domingues, Víctor Ângelo Folgosi, Sabri Saeed Sanabani

et al.

Revista do Instituto de Medicina Tropical de São Paulo, Journal Year: 2024, Volume and Issue: 66

Published: Jan. 1, 2024

The human T-cell lymphotropic virus type 1 (HTLV-1) is a single-stranded positive-sense RNA that belongs to the Retroviridae family, genus Deltaretro, and infects approximately five 10 million people worldwide. Although significant number of individuals living with HTLV-1 remain asymptomatic throughout their lives, some develop one or more severe clinical conditions, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), progressive debilitating disease, and/or subtype non-Hodgkin's lymphoma threatening course known adult leukemia/lymphoma (ATLL). Moreover, current therapeutic options are limited focus primarily on treating symptoms controlling viral latency. CRISPR-Cas9 gene editing proposed promising tool address intricate links associated HTLV-1. By targeting silencing key genes during initial infection dysregulating immune signaling pathways, offers potential intervention opportunities. In this review, we editing, well examine primary mechanisms involved in target discuss existing evidence scientific literature.

Language: Английский

Citations

0