Antibacterial Activity and Prebiotic Properties of Six Types of Lamiaceae Honey

Antibiotics, Journal Year: 2024, Volume and Issue: 13(9), P. 868 - 868

Published: Sept. 10, 2024

Our work investigated the antimicrobial and prebiotic properties of basil, mint, oregano, rosemary, savory, thyme honey. The potential action, assessed against pathogens

Language: Английский

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Antibiotics-induced dysbiosis impacts dendritic morphology of adult mouse cortical interneurons

Frontiers in Neuroanatomy, Journal Year: 2025, Volume and Issue: 19

Published: March 7, 2025

Introduction A growing body of evidence suggests that the gut microbiome may contribute to changes in brain morphology. The microbiota-gut-brain axis (MGBA) has been shown influence neurogenesis, axon myelination, and synapse structure. However, it remains unclear whether MGBA can morphology density inhibitory GABAergic interneurons. aim this study was determine antibiotic-induced dysbiosis (AID) is associated with alterations dendritic interneurons medial entorhinal cortex (mEC), somatosensory (SSC), motor (MC), hippocampus (Hp). Methods cohort six-month-old GAD-67-EGFP transgenic mice treated an antibiotic cocktail for two weeks, resulting as validated by collecting stool samples at baseline after treatment, then using next-generation sequencing 16S ribosomal RNA. Results results demonstrate proposed model effectively exhibited defining features dysbiosis, including a significant reduction diversity, expansion pathobionts, loss beneficial microbes. AID group showed different areas. mean length segments SSC Hp were found be significantly decreased, while no such decrease observed mEC or MC. Furthermore, decreased mEC, Hp, areas, change MC area. Discussion interneuron dysfunction plays role pathogenesis neurological disease. findings suggest potentially influences interneurons, which development disorders.

Language: Английский

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Manuka honey as a non-antibiotic alternative against Staphylococcus spp. and their small colony variant (SCVs) phenotypes

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: May 28, 2024

The antibiotic resistance (ABR) crisis is an urgent global health priority. Staphylococci are among the problematic bacteria contributing to this emergency owing their recalcitrance many clinically important antibiotics. Staphylococcal pathogenesis further complicated by presence of small colony variants (SCVs), a bacterial subpopulation displaying atypical characteristics including retarded growth, prolific biofilm formation, heightened tolerance, and enhanced intracellular persistence. These capabilities severely impede current chemotherapeutics, resulting in chronic infections, poor patient outcomes, significant economic burden. Tackling ABR requires alternative measures beyond conventional options that have dominated treatment regimens over past 8 decades. Non-antibiotic therapies gaining interest arena, use honey, which despite having ancient therapeutic roots has now been reimagined as just traditional topical use, include array difficult-to-treat staphylococcal infections. This literature review focused on Manuka honey (MH) its efficacy anti-staphylococcal treatment. We summarized studies used product technologies employed study antibacterial mechanisms render MH suitable agent for management those involving SCVs. also discussed status development other factors may impact therapy help combat ABR.

Language: Английский

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Honey-based therapeutics: a comprehensive review of anticancer, antioxidant, and prognostic impacts in breast cancer treatment

Journal of Cancer Prevention & Current Research, Journal Year: 2024, Volume and Issue: 15(2), P. 40 - 44

Published: Jan. 1, 2024

Background: Nowadays, breast cancer is one of the main causes deaths among women worldwide. It represents a major challenge in healthcare systems. With increasing rates mortality and adverse effects conventional therapy, prompt insight into honey-based therapeutics was crucial for developing new effective complementary alternative medicine. As natural product with its long history use traditional medicine, honey has drawn attention thousands scientists over past few years treating various types cancers, particularly cancer. Its anticancer properties are mainly attributed to complex composition valuable phyto compounds. Methods: In this review, our study sheds light on their properties, antioxidant potency, prognosis impact patients referring bibliographical data collected from 2020 2024. Discussion: Several studies unveiled outstanding potential modulate apoptosis, immune response, inflammation processes. healing powers could also be explained by potency preventive against oxidative stress which often cancers. Similarly, remarkable have been widely debated. Honey does not only improve life quality undergoing chemotherapy reducing side but increases survival rates. Conclusion: promising therapy that enhance effectiveness treatments.

Language: Английский

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Impact of mānuka honey on symptoms and quality of life in individuals with functional dyspepsia: a feasibility study protocol. (Preprint)

Published: Sept. 14, 2024

Functional dyspepsia is a common gastrointestinal condition characterised by symptoms such as epigastric pain or burning, early satiety, postprandial fullness, that negatively impacts quality of life, work productivity and healthcare costs. A lack well-defined causes for the limits effective treatment options. Consumers around world report using mānuka honey symptoms, including dyspepsia, although clinical evidence supporting use limited. Pre-clinical studies indicate unique compounds in may have bioactive properties could prevent inflammation. Recently, 3,6,7 trimethyllumazine (Lepteridine™), natural pteridine compound honey, was shown to inhibit enzymes involved inflammation vitro studies. Therefore, Lepteridine™ standardised deliver digestive health benefits. The aim this feasibility study gather data required estimate sample size support logistics design future trials. primary objective will be preliminary assessments impact on symptom severity life subjects with mild moderate functional dyspepsia. Other objectives include assessing biological responses medium high levels Lepteridine™, concentrations honey-derived metabolites blood urine following consumption. This three-arm, parallel, controlled, double-blind, randomised study. Seventy-five healthy adults (Rome IV Criteria) mild-to-moderate (Short Form Leeds Dyspepsia Questionnaire) were recruited between October 2022 September 2023. Participants into one three groups: 1) contain 10 mg/kg Lepteridine™; 2) 40 3) maple flavoured syrup control. After two-week lead-in period, participants consumed g their respective intervention twice daily six weeks. Throughout study, completed bowel movement diaries validated weekly questionnaires about life. Three-day diet records stool samples collected at baseline end intervention. Blood baseline, weeks two four, In addition, without undergo an acute five-hour assessment appearance related plasma consumption honey. approved Northern B Health Disability Ethics Committee. At time writing, laboratory analyses are being undertaken. results secondary outcomes published peer-reviewed journals. provide essential information potential efficacy suitability trials investigating effect Australian New Zealand Clinical Trials Registry, Trial Number ACTRN12622001140741p

Language: Английский

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The anticarcinogenic properties of manuka honey - a literature review

Quality in Sport, Journal Year: 2024, Volume and Issue: 25, P. 56542 - 56542

Published: Dec. 27, 2024

Background: Since antiquity, honey has been recognised for its healing and antibacterial properties. Recently, Manuka (MH) identified as possessing antioxidant, anti-inflammatory, antimutagenic, anticarcinogenic effects. Objective: This review examines the potential benefits of manuka honey, bioactive components, their effects on cancerogenesis, cancer growth, development. Methods: The PubMed Google Scholar databases were searched, 46 studies most relevant to research objective. Results: accompanying papers posit that MH may impede carcinogenesis by regulating various molecular pathways cell progression. A substantial body scientific evidence indicates a range types, including MH, can facilitate release reactive oxygen species cytokines (predominantly IL-1β, IL-6, TNF-α) innate immune system cells. Furthermore, have demonstrated stimulate T lymphocytes macrophages' proliferation functions while also inducing apoptosis cycle arrest in Conclusion: attesting properties continues grow. Several significant role promoting adaptive immunity, which is essential eliminating Nevertheless, further required provide comprehensive data regarding active constituents efficacy therapy.

Language: Английский

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Impact of mānuka honey on symptoms and quality of life in individuals with functional dyspepsia: a feasibility study protocol. (Preprint)

JMIR Research Protocols, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Language: Английский

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