Mucosal Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Sept. 20, 2024
Language: Английский
Citations
29
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Dec. 5, 2024
Abstract Neutrophils, the most abundant type of granulocyte, are widely recognized as one pivotal contributors to acute inflammatory response. Initially, neutrophils were considered mobile infantry innate immune system, tasked with immediate response invading pathogens. However, recent studies have demonstrated that versatile cells, capable regulating various biological processes and impacting both human health disease. Cytokines other active mediators regulate functional activity by activating multiple receptors on these thereby initiating downstream signal transduction pathways. Dysfunctions in disruptions neutrophil homeostasis been implicated pathogenesis numerous diseases, including cancer disorders, often due aberrant intracellular signaling. This review provides a comprehensive synthesis functions, integrating advancements this field. Moreover, it examines roles signaling pathways involved regulation activity. The pathophysiology diseases emerging therapeutic approaches targeting them also elaborated. addresses current limitations within field research, highlighting critical gaps knowledge warrant further investigation. In summary, seeks establish multidimensional model regulation, providing new perspectives for potential clinical applications research.
Language: Английский
Citations
6
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Feb. 6, 2025
Neutrophil extracellular traps (NETs) participate in both host defense and the pathogenesis of various diseases, such as infections, thrombosis, tumors. While they help capture eliminate pathogens, NETs' excessive or dysregulated formation can lead to tissue damage disease progression. Therapeutic strategies targeting NET modulation have shown potential, but challenges remain, particularly achieving precise drug delivery maintaining stability. Nanoparticle (NP)-based systems offer innovative solutions for overcoming limitations conventional therapies. This review explores biological mechanisms formation, their interactions with NPs, therapeutic applications NP-based modulating NETs. We discuss how NPs be designed either promote inhibit provide a comprehensive analysis potential treating NET-related diseases. Additionally, we address current future prospects therapies research, aiming bridge gap between nanotechnology development novel approaches.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 30, 2025
Abstract Functional biomaterials composed of multiple biomacromolecules have significant advantages over those made from a single type. However, harmoniously integrating various remains challenging. Neutrophil extracellular traps (NETs), an emerging biological structure released neutrophils, serve as natural prototype worth investigating and learning from. NETs consist intricate exhibit web‐like microstructure, endowing them with multifaceted roles in both physiological pathological processes. In this review, research progress is systematically examined on materials science perspective. First, the origin transformation are introduced, their functional mechanisms NET components thoroughly dissected rather than conventionally treating entity. Second, given complex functions, revealed potential biomarker for disease prediction. Third, typical characterization technologies analysis summarized. Fourth, artificial inspired by discussed. addition, regulatory processes provide bio‐inspired prototypes design advanced materials. Finally, perspectives opportunities challenges advancing presented biomarkers models development
Language: Английский
Citations
0
Veterinary Parasitology, Journal Year: 2025, Volume and Issue: 337, P. 110471 - 110471
Published: April 15, 2025
Language: Английский
Citations
0
mBio, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
ABSTRACT Neutrophil extrusion of neutrophil extracellular traps (NETs) in a process called NETosis provides immune defense against bacteria. It has been observed that bacteria are capable activating neutrophils to release NETs subsequently kill them or at least prevent their local spread within host tissue. However, existing studies have mainly focused on the isolated function NETs, with less attention given anti-bacterial mechanisms through interactions other cell populations. The net effect these complex intercellular interactions, which may act additively, synergistically, antagonistically, is critical determinant outcomes host–pathogen interactions. This review summarizes underlying classic NET formation and crosstalk system, offering novel insights aimed balancing anti-microbial potential inflammatory risks.
Language: Английский
Citations
0
Toxins, Journal Year: 2025, Volume and Issue: 17(5), P. 215 - 215
Published: April 24, 2025
Nucleases are critical metabolic enzymes expressed by mycoplasmas to acquire nucleic acid precursors from the host for their parasitic existence. Certain nucleases, either membrane-bound or secreted, not only contribute growth of but also serve as key virulence factors due unique spatial structures and physiological activity. The pathogenesis includes, is limited to, degradation DNA RNA, leading disruptions metabolism induction cell apoptosis; neutrophil extracellular traps (NETs), allowing escape neutrophil-mediated killing; upregulation inflammatory molecules modulate immune response host. Understanding biological functions nucleases essential gaining deeper insights into evasion strategies mycoplasmas, which can inform development novel approaches prevention, diagnosis, treatment mycoplasma infections.
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 758, P. 110067 - 110067
Published: June 20, 2024
Language: Английский
Citations
3
Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 467 - 467
Published: April 16, 2024
Ocular exposure to particulate matter (PM) causes local inflammation; however, the influence of neutrophils on PM-induced ocular inflammation is still not fully understood. In this study, we constructed a system investigate role PM in using co-culture human corneal epithelial cells (HCE-T) and differentiation-induced (dHL-60). To whether HCE-T directly endocytosed PM, performed holographic analysis, which showed endocytosis HCE-T. The cytokines chemokines produced by were measured an ELISA. treated with IL-6 IL-8, inhibited N-Acetyl-L-cysteine (NAC), suggesting involvement ROS. Their dHL-60 enhanced their production IL-6, MCP-1. This suggests inflammatory loop involving intraocular neutrophils. These are mainly regulated NF-κB. Therefore, was examined presence IKK inhibitor known downregulate NF-κB activity. dramatically suppressed these factors supernatants. results suggest that observed mediated through ROS transcription factor Thus, considered valuable tool for analyzing complex inflammations.
Language: Английский
Citations
2
EBioMedicine, Journal Year: 2024, Volume and Issue: 108, P. 105340 - 105340
Published: Sept. 19, 2024
Language: Английский
Citations
2