Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China

Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1460 - 1460

Published: May 12, 2024

Negative emotions and gut microbiota during pregnancy both bear significant public health implications. However, the relationship between them has not been fully elucidated. This study, utilizing data from a cohort, employed metagenomic sequencing to elucidate anxiety, depression, microbiota’s diversity, composition, species, functional pathways. Data 87 subjects, spanning 225 time points across early, mid, late pregnancy, were analyzed. The results revealed that anxiety depression significantly corresponded lower alpha diversity (including Shannon entropy Simpson index). Anxiety scores, along with categorical distinctions of anxiety/non-anxiety depression/non-depression, found account for 0.723%, 0.731%, 0.651%, 0.810% variance in gut-microbiota composition (p = 0.001), respectively. Increased was positively associated abundance Oscillibacter sp. KLE 1745, PEA192, 1728, Oscillospiraceae bacterium VE202 24, Treponema socranskii. A similar association noted 1745 elevated scores. While EC.3.5.3.1: arginase appeared be higher anxious group than non-anxious group, vitamin B12-related enzymes non-depression group. changes statistically after post-multiple comparison adjustment.

Language: Английский

---

Differences in maternal diet fiber content influence patterns of gene expression and chromatin accessibility in fetuses and piglets

Genomics, Journal Year: 2025, Volume and Issue: 117(2), P. 110995 - 110995

Published: Jan. 13, 2025

This study investigates the impact of maternal gestation diets with varying fiber contents on gene expression and chromatin accessibility in fetuses piglets fed a low diet post weaning. High-fiber diets, enriched sugar beet pulp or pea internal fiber, were compared to low-fiber evaluate their effects liver muscle tissues. The findings demonstrate that high-fiber significantly alter accessibility, predicted transcription factor activity transcriptional landscape both piglets. A set enrichment analysis revealed over-expression ontology terms related metabolic processes under-expression those linked immune responses from sows given during gestation. suggests better health tolerance fetus offspring, line documented epigenetic short chain fatty acids pathways. deconvolution bulk RNA-seq data was performed using cell-type specific markers single cell transcriptome atlas adult pigs. These results confirmed transcriptomic do not reflect different type compositions between groups but rather phenotypic changes triggered by nutrition shaping environment offspring. Our have implications for improving animal productivity as well broader human health, suggesting optimizing content could enhance function formative years after birth potentially adulthood.

Language: Английский

---

Gut microbiota causes depressive phenotype by modulating glycerophospholipid and sphingolipid metabolism via the gut-brain axis

Psychiatry Research, Journal Year: 2025, Volume and Issue: 346, P. 116392 - 116392

Published: Feb. 7, 2025

Language: Английский

---

Microbiome and Pregnancy Dysbiosis: A Narrative Review on Offspring Health

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1033 - 1033

Published: March 15, 2025

Background: Emerging evidence suggests that the maternal microbiome plays a crucial role in shaping fetal neurodevelopment, immune programming, and metabolic health. Dysbiosis during pregnancy—whether gastrointestinal, oral, or vaginal—can significantly influence pregnancy outcomes long-term child Materials Methods: The search was performed using databases such as PubMed, Scopus, Google Scholar including research published from January 2000 to 2025. keywords used were “Fetal Programming”, “ Maternal Immune Activation”, “Maternal microbiome”, “Microbiota–Gut–Brain Axis”, “Pregnancy Dysbiosis”. Results: undergoes substantial changes pregnancy, with alterations microbial diversity function linked conditions gestational diabetes, obesity, preeclampsia. Pregnancy-related dysbiosis has been associated adverse neurodevelopmental outcomes, an increased risk of autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), cognitive impairments offspring. Conclusions: Understanding intricate relationship between microbiota health is essential for developing targeted interventions. Personalized microbiome-based strategies, dietary modifications probiotic supplementation, hold promise optimizing promoting

Language: Английский

---

Parity influences postpartum adaptations in the maternal gut microbiota

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

The gut microbiome undergoes substantial modifications during pregnancy, yet its postpartum adaptations remain poorly understood, particularly with respect to the influence of parity. Here, we investigated impact childbirth history on maternal composition and function one month postpartum. By conducting metagenomic sequencing analysis 60 participants (34 mothers 26 controls), demonstrated significant differences in microbial diversity community structure between control, as well subtle first-time multiple-birth mothers. We identified parity-specific signatures, showing enrichment Dysosmobacter welbionis, Candidatus Saccharibacteria, Anaerotruncus species. Functional revealed distinct metabolic reprogramming patterns, including increased amino acid biosynthesis modified fermentation pathways supporting recovery. observed correlations specific bacterial taxa pathways, energy metabolism immune modulation. Notably, enhanced capacity for short-chain fatty production primiparous mothers, mediated by Anaerotruncus D. welbionis, suggests a potential role shaping breast milk composition, which may neonatal development. These findings establish concept parity-dependent programming provide insights into biological mechanisms underlying adaptation pregnancy childbirth.

Language: Английский

---

Abnormal microbiota due to prenatal antibiotic as a possible risk factor for Attention-Deficit / Hyperactivity Disorder (ADHD)

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

---

Relationship between gastrointestinal disturbances, blood lipid levels, inflammatory markers, and preterm birth

Journal of Obstetrics and Gynaecology, Journal Year: 2025, Volume and Issue: 45(1)

Published: April 20, 2025

The challenging incidence of preterm birth, the underlying causes birth remain unclear. This study determined relationship between disturbed gastrointestinal symptoms, inflammatory markers, blood lipid levels, and birth. One hundred twenty pregnant women with labour were compared to 120 full-term deliveries. All subjects underwent lactose breath serologic testing. correlation small intestinal bacterial overgrowth (SIBO)-positivity, factors, metabolism was analysed using Spearman method. SIBO, hydrogen, methane levels significantly higher in (PTB) group than (FTB) at different time points (P < 0.05); Levels high-sensitivity C-reactive protein (hs-CRP) (3.95[2.70-5.77] vs. 2.47[1.45-3.83]), Interleukin (IL)-10 (3.05[2.27-4.33] 2.09[1.04-3.47]), IL-6 (5.23[3.95-8.50] 2.98[2.22-4.44]), tumour necrosis factor -alpha (TNF-α) (3.23[1.55-4.90] 1.76[0.98-3.10]), total cholesterol (TC) (5.52[4.97-5.95] 5.24[4.73-5.85]), triglycerides (TG) (2.58[2.04-3.53] 2.24[1.59-3.05]) PTB FTB 0.05). Abdominal distension (2.67[1.67-3.00] 2.33[1.67-2.67]) constipation (2.00[1.33-2.00] 1.67[1.33-2.00]) scores also markedly Preterm positively correlated TC, TG levels. Additionally, SIBO hs-CRP, IL-10, IL-6, TNF-α abdominal distension, Logistic regression analysis found close association positive biochemistry indicators Gastrointestinal disturbances, hyperlipidaemia SIBO-positivity are more likely occur among labour. Further research a large sample size multi-centers is needed validate results.

Language: Английский

---

The Influences of Oral Probiotics on the Immunometabolic Response During Pregnancy and Lactation: A Systematic Review

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1535 - 1535

Published: April 30, 2025

Background/Objectives: In recent years, due to the emergence of antimicrobial resistance, probiotics have been increasingly used during pregnancy and lactation with real maternal–fetal benefits. Probiotic intervention, especially multi-strain probiotics, their anti-inflammatory, metabolic, immunomodulatory actions, can be performed prophylactically therapeutically promising results regarding maternal, fetal, neonatal health. The administration modulate maternal microbiome, regulate microflora imbalance in various conditions (overweight/obesity, gestational diabetes mellitus (GDM), preeclampsia, allergic diseases), influence several reactions such as modulating non-specific cellular immune system, metabolic processes, inhibition pathogens. This study aimed analyze, based on available data, how probiotic supplements women modify immunometabolic responses microbial dysbiosis limit weight gain risk obesity, improve glucose homeostasis reduce GDM, prevent preeclampsia its effects outcomes, rates atopic eczema diseases infants. Methods: We a systematic search MEDLINE/PubMed identify studies that investigated intervention response lactation, diabetes, overweight/obesity, conditions. Results: Fifty-six RCT studies, totaling 15,044 women, matched inclusion criteria, which eight were for interventions response, twenty conditions, seven obesity excess pregnancy, twenty-one GDM. Conclusions: Due heterogeneous structure size samples, methodologies, formulations, moment initiation, durations, future research is needed establish effectiveness safety maternal-fetal health outcomes childhood adult life.

Language: Английский

---

Different Levels of Therapeutic Strategies to Recover the Microbiome to Prevent/Delay Acute Lymphoblastic Leukemia (ALL) or Arrest Its Progression in Children

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3928 - 3928

Published: March 31, 2024

Changes in the components, variety, metabolism, and products of microbiomes, particularly gut microbiome (GM), have been revealed to be closely associated with onset progression numerous human illnesses, including hematological neoplasms. Among latter pathologies, there is acute lymphoblastic leukemia (ALL), most widespread malignant neoplasm pediatric subjects. Accordingly, ALL cases present a typical dysfunctional GM during all its clinical stages resulting inflammation, which contributes progression, altered response therapy, possible relapses. Children characteristic variations composition, functions, such alterations may influence predict complications prognosis after chemotherapy treatment or stem cell hematopoietic transplants. In addition, growing evidence also reports ability formation, growth, roles newborn's system through process developmental programming fetal life as well susceptibility onco-hematological namely ALL. Here, we suggest some therapeutic strategies that can applied at two levels intervention recover consequently prevent/delay arrest progression.

Language: Английский

---

Microbiota and Recurrent Pregnancy Loss (RPL); More than a Simple Connection

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1641 - 1641

Published: Aug. 10, 2024

Recurrent Pregnancy Loss (RPL) affects 1–2% of women, and its triggering factors are unclear. Several studies have shown that the vaginal, endometrial, gut microbiota may play a role in RPL. A decrease quantity Lactobacillus crispatus local has been associated with an increase (vaginal endometrial) inflammatory response immune cell activation leads to pregnancy loss. The be triggered by gram-negative bacteria, lipopolysaccharides (LPS), viral infections, mycosis, or atypia (tumor growth). Bacterial structures metabolites produced could involved modulation responsible for molecular mimicry. Gut metabolic products amount circulating pro-inflammatory lymphocytes, which, turn, will migrate into vaginal endometrial tissues. Local Th1 Th17 subpopulations Treg tolerogenic NK cells accountable modulate response, increasing success. Analyzing necessary characterize some RPL patients. Although oral supplementation probiotics not modify microbiota, it benefit transplantation vagina enhance required achieve normal pregnancy. effect hormone stimulation progesterone maintain early on adequately studied, more research is needed this area. Well-designed clinical trials ascertain

Language: Английский

---