PEDIATRIC ENTEROCOLITIS: CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES DOI Creative Commons
Cristina Maria Mihai, Lorenza Forna, Ginel Baciu

et al.

Published: Dec. 20, 2024

Diarrhea is a leading cause of illness and death in children under five years old. Severe cases diarrhea, particularly those resulting dehydration, are major factor high mortality rates. Rotavirus significant pathogen contributing to dehydrating diarrhea hospitalizations five. The aim this study was investigate the role vaccination preventing progression gastroenteritis, with focus on rotavirus-induced gastroenteritis. Material methods: present conducted within Pediatric Department Emergency Clinical Hospital “St. Apostle Andrew” Constanța, including 307 patients diagnosed acute gastroenteritis during period January 1 December 31, 2023. Results: prevalence declined age: 183 infants, 67 were between 3 old, 42 aged 7, smallest group, 15 patients, 7 16 201 did not receive Rotarix or Rotateq vaccines, while 106 completed full regimen. As for etiology disease, 160 viral enterocolitis, 142 attributed Rotavirus. An increase dehydration electrolyte imbalances observed subjects who had received preventive vaccine. Conclusion: vaccine severe that caused by Rotavirus, highlighted reduced frequency imbalances, shorter hospital stays Rotarix/Rotateq

Language: Английский

Overview of Oxidative Stress in Systemic Lupus Erythematosus DOI Creative Commons
Ancuţa Ignat, Gabriela Stoleriu, Alin Horațiu Nedelcu

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 303 - 303

Published: March 1, 2025

Systemic lupus erythematosus (SLE) is an autoimmune disease that frequently diagnosed in female patients, caused by multiple interacting factors. It has a complex pathogenesis which can affect almost any organ, from the kidneys to cardiovascular, pulmonary, neurological, osteoarticular, and hematological systems. The present narrative review seeks elucidate role of reactive oxygen species (ROS) SLE. central question guiding this study what extent these serum protein modifications correlate with activity organ damage characterized decreased apoptosis increased necrosis T cells NETosis granulocytes. Given impact SLE diagnosis on one's life, aims evaluate intricacies oxidative stress its relevance treatment disease. Topics such as understanding processes stress, their damaging pathways, biomarkers, future assistance clinical decisions will be discussed article. accurate determination biomarkers taught improve both management disease, while antioxidant therapy may open new door for treatment.

Language: Английский

Citations

1
Variations in vitamin D status among Chinese children aged 1–6 years during the COVID-19 pandemic DOI Creative Commons

Y. Qiao,

Xiaoqin Wang, Yanfen Ma

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 23, 2025

Background Vitamin D deficiency has been a critical global health issue within the pediatric population. Closed-off management brought about by COVID-19 pandemic drastically impacted outdoor activities and sunlight exposure, however, whether it indirectly further exacerbated vitamin not largely investigated, especially among children in China. The purpose of this study was to evaluate 25(OH)D concentrations before during lockdown analyze factors influencing their status. Methods A cross-sectional survey included aged 1–6 years from Han Zhong Central Hospital southern Shanxi Province This examined healthy care department over two periods: (March 2019–February 2020), 2020–February 2021). Total were compared between observation periods. status determined concentrations: deficient (<20 ng/ml), insufficient (20–29 sufficient (30–100 ng/ml). Results involved 6,780 children, with 52.8% being 1-year-olds, 23.1% 2-year-olds, 24.1% 3 6-year-olds. Boys girls 52.8 47.2%, respectively. actual prevalence nutritional 2.8%, 87.1% cases those 6 years. insufficiency 18.3%, affecting 54.8% same demographic. average concentration 38.2 ± 9.8 ng/ml, significantly varying age season. decreased age, 42.3 8.8 ng/ml at 1-year-olds 37.4 8.2 30.2 8.1 Seasonal variations showed that higher spring (38.7 10.1 summer 10.0 fall (38.6 9.2 ng/ml) comparison winter (36.0 Additionally, exhibited decrease (37.9 10.3 pre-pandemic measurements (39.3 9.9 ( p = 0.008), while increased (35.1 10.4 0.002). Conclusion research indicated is uncommon Chinese experiencing notable decline 3–6 findings suggested potential need for tailored supplementation strategies possibly doses group, along monitoring effectiveness. COVID-19-related restrictions minimally affected children’s concentrations, revealing implications pandemic.

Language: Английский

Citations

0
Challenging directions in pediatric diabetes - the place of oxidative stress and antioxidants in systemic decline DOI Creative Commons
Vasile Valeriu Lupu, Ingrith Miron, Laura Mihaela Trandafir

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 18, 2024

Diabetes is a complex condition with rising global incidence, and its impact equally evident in pediatric practice. Regardless of whether we are dealing type 1 or 2 diabetes, the development complications following onset disease inevitable. Consequently, contemporary medicine must concentrate on understanding pathophysiological mechanisms driving systemic decline finding ways to address them. We particularly interested effects oxidative stress target cells organs, such as pancreatic islets, retina, kidneys, neurological cardiovascular systems. Our goal explore, using latest data from international scientific databases, relationship between persistence damage associated diabetes children. Additionally, highlight beneficial roles antioxidants vitamins, minerals, polyphenols, other bioactive molecules; mitigating pathogenic cascade, detailing how they intervene their properties. As result, our study provides comprehensive exploration key aspects stress-antioxidants-pediatric triad, expanding significance various diseases.

Language: Английский

Citations

3
Undercover lung damage in pediatrics - a hot spot in morbidity caused by collagenoses DOI Creative Commons

Ancuța Lupu,

Maria Oana Mărginean, Elena Jechel

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

Connective tissue represents the support matrix and connection between tissues organs. In its composition, collagen, major structural protein, is main component of skin, bones, tendons ligaments. Especially at pediatric age, damage in context pathologies such as systemic lupus erythematosus, scleroderma or dermatomyositis can have a significant negative impact on development optimal functioning body. The consequences extend to various structures (e.g., joints, eyes, lungs, heart, kidneys). Of these, we retain reveal later our manuscript, mainly respiratory involvement. Manifested forms that chest wall, pleura, interstitium vascularization, lung inflammatory diseases underdeveloped literature compared described adults. Under threat severe evolution, sometimes rapidly progressive leading death, it necessary increase popularization information aimed physiopathological triggering maintenance mechanisms, diagnostic means, therapeutic directions among medical specialists. addition, emphasize need for interdisciplinary collaboration, especially pediatricians, rheumatologists, infectious disease specialists, pulmonologists, immunologists. Through narrative review bring up date, concise easy assimilate, general principles regarding pulmonary collagenoses using most recent articles published international libraries, duplicated by previous articles, reference targeted pathologies.

Language: Английский

Citations

0
Metabolic syndrome therapy in pediatric age — between classic and modern. From diets to pipeline drugs DOI Creative Commons
Otilia Elena Frăsinariu, Vasile Valeriu Lupu, Laura Mihaela Trandafir

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 11, 2024

The metabolic syndrome, made up of the sum entities that define it (obesity, hypertension, dyslipidemias and non-alcoholic hepatic steatosis) has gained an important place in research last decades. This aspect is mainly due to complexity management pediatric practice. main directions his approach therefore bring together concern counteracting noise or systemic, multiple intercurrents at physiopathological level, as well negative imprint exerted on quality life. Its appearance evolution are currently controversial topics, but influence genetic predisposition lifestyle (diet, physical activity, psychological balance) certainties. Considering escalation incident global self-evident necessary know pathogenesis practice countermeasures for prophylactic therapeutic purposes. present work aims summarize general aspects related syndrome encountered age, with emphasis complementary perspectives their effectiveness, by analyzing latest data from specialized literature, accessed help international databases (e.g., PubMed, Web Science, Scopus, Embase, Google Scholar).

Language: Английский

Citations

0
PEDIATRIC ENTEROCOLITIS: CLINICAL MANIFESTATIONS AND MANAGEMENT STRATEGIES DOI Creative Commons
Cristina Maria Mihai, Lorenza Forna, Ginel Baciu

et al.

Published: Dec. 20, 2024

Diarrhea is a leading cause of illness and death in children under five years old. Severe cases diarrhea, particularly those resulting dehydration, are major factor high mortality rates. Rotavirus significant pathogen contributing to dehydrating diarrhea hospitalizations five. The aim this study was investigate the role vaccination preventing progression gastroenteritis, with focus on rotavirus-induced gastroenteritis. Material methods: present conducted within Pediatric Department Emergency Clinical Hospital “St. Apostle Andrew” Constanța, including 307 patients diagnosed acute gastroenteritis during period January 1 December 31, 2023. Results: prevalence declined age: 183 infants, 67 were between 3 old, 42 aged 7, smallest group, 15 patients, 7 16 201 did not receive Rotarix or Rotateq vaccines, while 106 completed full regimen. As for etiology disease, 160 viral enterocolitis, 142 attributed Rotavirus. An increase dehydration electrolyte imbalances observed subjects who had received preventive vaccine. Conclusion: vaccine severe that caused by Rotavirus, highlighted reduced frequency imbalances, shorter hospital stays Rotarix/Rotateq

Language: Английский

Citations

0