Association between the systemic immune-inflammation index and sarcopenia in older adults: a cross-sectional study

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 13, 2025

Chronic inflammation is increasingly recognized as a crucial contributor to sarcopenia pathogenesis, but accurate diagnosis remains challenge. Our study aims investigate the relationship between and Systemic Immune-Inflammation Index (SII), comprehensive indicator of inflammation. This cross-sectional enrolled 632 patients. All participants underwent geriatric assessment. Sarcopenia was assessed through evaluation handgrip strength calf circumference. To determine SII, we used formula: Platelet count (109/mm3)×Neutrophil (109/mm3) / Lymphocyte (109/mm3). The average age 74.8 ± 6.4, 62.3% (n = 394) were female. Patients grouped non-sarcopenic sarcopenic. group had 536 patients (84.8%), while sarcopenic comprised 96 (15.2%). Sarcopenic showed higher median SII score than (p < 0.001). Multivariate logistic regression analysis revealed that significantly independently associated with even after adjusting for potential confounding factors (β 1.002, 95% CI 1.001–1.003, p ROC identified optimal cut-off in predicting > 765. At this threshold, negative predictive values determined be 88.1%, specificity 88%. outpatient population, population-specific may serve novel, simple, practical biomarker diagnosing sarcopenia.

Language: Английский

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Association of nutritional and inflammatory status with all-cause and cardiovascular mortality in adults with sarcopenia: Insights from NHANES

Maturitas, Journal Year: 2025, Volume and Issue: 196, P. 108233 - 108233

Published: March 4, 2025

Language: Английский

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Age difference in the connection between systemic inflammatory response and metabolic syndrome

The Journal of Clinical Endocrinology & Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Abstract Background This research aims to investigate the connection between systemic inflammatory response and metabolic syndrome (MetS) across different age groups, with aim of proposing more targeted recommendations. Methods study enrolled 15 959 adults from 2001-2018 National Health Nutrition Examination Survey whom 6739 were diagnosed MetS. After dividing immune-inflammation index (SII) into 4 quartiles, Kruskal–Wallis test weighted chi-square employed assess statistical differences. Weighted multivariable logistic regression analysis, subgroup sensitivity restricted cubic spline examine relationship SII Results Our revealed that exhibits a quantitative association MetS [odds ratio (OR) = 1.56; 95% confidence interval (CI): 1.37-1.79; P &lt; .001]. Elevated is an independent risk factor for 5 components Different groups alcohol consumption status could modify was statistically significant in 18 65 group but not elderly (OR 1.08; CI, .95-1.23; .248). Multiple imputation confirmed robustness our results. Moreover, inverted U-shaped curve. Conclusion highlights predictive significance forecasting incidence young middle-aged populations. The differences mechanisms various necessitate further exploration.

Language: Английский

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Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: April 18, 2025

Abstract Background Tooth loss was linked to health status, with substantial implications for malnutrition and chronic inflammation risks in older adults, especially among vulnerable groups. This study aimed explore the associations between tooth severity, denture geriatric syndromes. Methods In 2019, 1094 participants were recruited subjected face-to-face interview assess along grip strength body composition. 2023, a follow-up conducted subsample of participants. Logistic regression analysis utilized association severity at baseline syndromes (sarcopenia, risk, frailty, fall) fourth year follow-up, as well status Results The multivariate analyses showed that having affecting daily life associated 1.80-fold higher prevalence sarcopenia 2.31-fold risk after four years. Participants fewer than 10 teeth had significantly odds compared those 21 or more teeth: 1.87-fold (95% CI: 1.07 3.26), 2.99-fold 1.93 4.62), 1.68-fold frailty 1.10 2.56). Older adults who did not have dentures exhibited sarcopenia, falls, number Conclusion Higher level adults. Dentures partially mitigate Screening intervening oral is important prevention Clinical trial Not applicable.

Language: Английский

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Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: March 10, 2025

Background This research delved into the association between systemic immune-inflammatory index (SII) and both all-cause cancer-specific mortality among individuals aged 60 years above in United States during period from 1999 to 2018, with follow-up extending until 31 December 2019. The data utilized was sourced 4295 population-based participants National Health Nutrition Examination Survey (NHANES). Methods To analyze relationship SII mortality, study employed Cox proportional-risk models, restricted cubic spline curves, survival subgroup analyses. Results average age of 70.7 (±7.6) years, median duration 131.7 (±59.8) months, rate stood at 50.5%. Findings regression model indicated that, after adjusting for covariates, significantly linearly related (hazard ratio HR = 1.31, 95% confidence interval CI 1.15–1.48). Moreover, cancer exhibited a U-shaped pattern. curves suggested that higher associated an augmented risk mortality. Conclusion There is significant levels increased US population older.

Language: Английский

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Inflammatory Indices in First Trimester as Predictors of Gestational Diabetes Mellitus and Adverse Pregnancy Outcomes

American Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 93(4)

Published: April 1, 2025

ABSTRACT Objectives To explore the association between systemic inflammatory markers (systemic inflammation response index [SIRI], immune [SII], interleukin [IL]‐33, and soluble tumorigenicity 2 [sST2]) gestational diabetes mellitus (GDM), as well adverse pregnancy outcomes (APOs), to assess impact of glycemic control on these relationships. Methods A total 777 participants were included, comprising 476 women with GDM 301 without. Clinical characteristics, markers, analyzed. Logistic regression was employed risk APOs associated elevated indices control. Diagnostic performance evaluated using receiver operating characteristic (ROC) curves. Results Women exhibited significantly higher levels SII, SIRI, IL‐33, sST2. Multivariate logistic demonstrated that sST2 independent predictors GDM. Moreover, highest tertiles IL‐33 strongly APO risk. ROC analysis revealed SII had predictive value for (AUC 0.763), while greatest accuracy 0.669). Effective reduced marker (SII, aOR 3.9; 3.7; 2.4) a decreased large‐for‐gestational‐age (LGA) infants in Conclusions Elevated are significant APOs, being most robust predictor APOs. Glycemic reduces may improve

Language: Английский

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Plumbagin alleviates muscle atrophy in female mice through inhibiting the DANCR/NF-κB axis

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156282 - 156282

Published: Nov. 28, 2024

Language: Английский

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Changes in sarcopenia and incident cardiovascular disease in prospective cohorts

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 31, 2024

Previous studies have identified sarcopenia as a significant risk factor for cardiovascular disease (CVD). However, these primarily focused on status at baseline, without considering changes in during follow-up. The aim of this study is to investigate the association between and incidence new-onset disease.

Language: Английский

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Systemic immune-inflammatory index predicts fragility fracture risk in postmenopausal anemic females with type 2 diabetes mellitus: evidence from a longitudinal cohort study

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 27, 2024

Chronic low-grade inflammation is related to bone metabolism in patients with type 2 diabetes mellitus (T2DM). However, credible data indicating the relationship between and fragility fracture risk postmenopausal anemic females T2DM are sparse. The current study sought investigate relationships systemic immune-inflammatory index (SII) events, as well future 10-year probability evaluated using assessment tool (FRAX) T2DM. According tertiles of SII, 423 were divided into three groups: low-level (≤ 381.32, n = 141), moderate-level (381.32–629.46, high-level (≥ 629.46, 141). All participants followed up for 7 years a median 46.8 months (1651 person-years). association SII was assessed. Of subjects, 75 experienced event. Spearman partial correlation analysis revealed that negatively mineral density (BMD) positively associated major osteoporotic (MOF) hip (HF). Restricted cubic spline (RCS) positive an approximately inverted J-shaped dose–response pattern (P overall < 0.0001). Multivariate Cox regression demonstrated high presented greater fractures 0.011). Stratified predominantly anemia increase 4.15 times 0.01). Kaplan‒Meier indicated cumulative incidence (log-rank, all P 0.0012). Receiver operating characteristic (ROC) optimal cut-off value 537.34, area under curve (AUC) 0.646, sensitivity 60%, specificity 64.1% 0.001). significant real-world event T2DM, particularly evident individuals anemia. Therefore, monitoring hemoglobin older women helpful routine clinical practice identify at promptly execute appropriate intervention procedures.

Language: Английский

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Association of Serum Copper, Zinc, and Zinc/Copper Ratio with Epilepsy: A Cross-Sectional Study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 11, 2024

Using data from the National Health and Nutrition Examination Survey (NHANES) in United States, this study examines association between serum copper, zinc, zinc/copper ratio with epilepsy. This utilized American adults obtained NHANES cycles of 2013–2014 2015–2016. To assess relationship epilepsy, a weighted logistic regression model was employed. Age gender were analyzed as subgroups. Based on analysis, found to be negatively correlated In fully adjusted model, OR (95% CI) for intermediate levels zinc 0.37(0.17–0.80), high ratio, 0.18(0.08–0.43). Serum copper positively epilepsy individuals over 40 years old. For 40–59 age group, 4.22(1.16–15.36) 3.85(1.21–12.27), respectively. The concludes that are inversely related among adults, while exhibits positive aged 40, particularly within group.

Language: Английский

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