Identification biomarkers in disease progression of obstructive sleep apnea from children serum based on WGCNA and Mfuzz DOI Creative Commons

Simin Gao,

Dan Shan,

Yuedi Tang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

Obstructive sleep apnea (OSA) syndrome is a prevalent form of respiratory disorder, with an increasing prevalence among children. The consequences OSA include obesity, diabetes, cardiovascular disease, and neuropsychological diseases. Despite its pervasive impact, significant proportion individuals especially children remain unaware that they suffer from OSA. Consequently, there urgent need for accessible diagnostic approach. In this study, we conducted bioinformatic analysis to identify potential biomarkers proteomics dataset comprising serum samples in the progression stage. Gene Set Enrichment Analysis (GSEA), observed complement immune response pathways persisted throughout development could be detected early stages. Subsequent soft clustering WGCNA analysis, it was revealed Hippo pathway, including ITGAL FERMT3, plays role mild alteration coagulation pathways, TFPI MLB2, moderate severe OSA, association between hypoxia extracellular matrix (ECM) receptor interaction collagen binding. summary, can posited systemic inflammation may persist Furthermore, characterized by abnormal vascular endothelial function, which attributed chronic hypoxia. Finally, four (ITGAL, TFPI, TTR, ANTXR1) were identified based on LASSO regression, prediction model constructed biomarkers.

Language: Английский

Immune dynamics throughout life in relation to sex hormones and perspectives gained from gender-affirming hormone therapy DOI Creative Commons
Ahmet Yalçınkaya, Rümeysa Yalçınkaya,

Fabian Sardh

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 16, 2025

Biological sex is closely associated with the properties and extent of immune response, males females showing different susceptibilities to diseases variations in immunity. Androgens, predominantly males, generally suppress responses, while estrogens, more abundant females, tend enhance It also established that hormones at least partially explain biases diseases, particularly autoimmune females. These differences are influenced by hormonal, genetic, environmental factors, vary throughout life stages. The advent gender-affirming hormone therapy offers a novel opportunity study immunological effects hormones. Despite limited studies on this topic, available research has revealed testosterone transgender men may certain functions, such as type I interferon increasing inflammation markers like TNF-α. Transgender women estrogen experience alterations coagulation-related inflammatory characteristics. Furthermore, other possible regulation can be inferred from assessment individuals receiving therapy. Understanding complex interactions between system, through unique perspective offered therapies, facilitate development targeted therapies for infections improving healthcare outcomes individuals. Here we review dynamics both sexes provide summary findings drawn exploring

Language: Английский

Citations

1
Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review DOI Open Access
Juan Bautista De Sanctis,

Germán Balda Noria,

Alexis García

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 862 - 862

Published: Jan. 20, 2025

Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between vaccine formulation and recipient’s immune system, ultimately resulting in protection against disease. Significant variability exists individual population responses to vaccination, these differences remain focus ongoing research. Notably, well-documented factors, such as age, gender, genetic predisposition, influence responses. In contrast, effects overweight obesity have not been thoroughly investigated. The evidence indicates that high body mass index (BMI) constitutes significant risk factor infections general, with adipose tissue playing crucial role modulating response. Furthermore, suboptimal levels seroconversion observed among individuals obesity. This review provides plausible examination immunity conferred by various vaccines status, offering comprehensive analysis mechanisms enhance vaccination efficiency.

Language: Английский

Citations

0
The different innate immune response to infections in males and females emerges before birth DOI Creative Commons
Valentina Margarita, Valeria Lodde, Paola Rappelli

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123521 - 123521

Published: March 1, 2025

Language: Английский

Citations

0
Gender and sex interactions are intrinsic components of cancer phenotypes DOI
Joshua B. Rubin

Nature reviews. Cancer, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Language: Английский

Citations

0
Sex Disparities in Staphylococcus aureus Bacteremia Mortality DOI Creative Commons

Bethan L. Carter,

Jonathan Underwood

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(10), P. e2441502 - e2441502

Published: Oct. 30, 2024

This cohort study examines sex differences in 30- and 90-day mortality among patients with Staphylococcus aureus bacteremia Wales, United Kingdom.

Language: Английский

Citations

2
Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo DOI Creative Commons
Michael P. Bokoch,

Fengyun Xu,

Krishna Govindaraju

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 3, 2024

Introduction Patients with cirrhosis undergoing liver transplantation frequently exhibit systemic inflammation, coagulation derangements, and edema, indicating endothelial dysfunction. This syndrome may worsen after ischemia–reperfusion injury of the graft, coincident organ dysfunction that worsens patient outcomes. Little is known about changes in permeability during transplantation. We hypothesized sera from these patients would increase cultured human cells ex vivo . Methods Adults presenting for provided consent blood collection surgery. Sera were prepared at five time points spanning entire operation. The barrier function pulmonary microvascular culture was assessed by transendothelial resistance measured using ECIS ZΘ system. Confluent two different cell donors stimulated serum transplant patients. Pooled healthy men purified inflammatory agonists served as controls. response to quantified area under normalized curve. Responses compared between analyzed associations clinical characteristics their grafts. Results Liver all surgery-induced both lines. magnitude change heterogeneous patients, there differences effects on In one lines, severity disease associated greater start same line, collected 15 min reperfusion induced significantly more Early postreperfusion living donor transplants than deceased transplants. exemplary cases preoperative dialysis, an unexpectedly long warm ischemia exaggerated prolonged permeability. Discussion Serum induces cells. Increased contribute present a target future therapeutics.

Language: Английский

Citations

0
Identification biomarkers in disease progression of obstructive sleep apnea from children serum based on WGCNA and Mfuzz DOI Creative Commons

Simin Gao,

Dan Shan,

Yuedi Tang

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

Obstructive sleep apnea (OSA) syndrome is a prevalent form of respiratory disorder, with an increasing prevalence among children. The consequences OSA include obesity, diabetes, cardiovascular disease, and neuropsychological diseases. Despite its pervasive impact, significant proportion individuals especially children remain unaware that they suffer from OSA. Consequently, there urgent need for accessible diagnostic approach. In this study, we conducted bioinformatic analysis to identify potential biomarkers proteomics dataset comprising serum samples in the progression stage. Gene Set Enrichment Analysis (GSEA), observed complement immune response pathways persisted throughout development could be detected early stages. Subsequent soft clustering WGCNA analysis, it was revealed Hippo pathway, including ITGAL FERMT3, plays role mild alteration coagulation pathways, TFPI MLB2, moderate severe OSA, association between hypoxia extracellular matrix (ECM) receptor interaction collagen binding. summary, can posited systemic inflammation may persist Furthermore, characterized by abnormal vascular endothelial function, which attributed chronic hypoxia. Finally, four (ITGAL, TFPI, TTR, ANTXR1) were identified based on LASSO regression, prediction model constructed biomarkers.

Language: Английский

Citations

0