Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not DOI Creative Commons
Kiyoko Iwatsuki‐Horimoto, Maki Kiso,

Mutsumi Ito

et al.

npj Viruses, Journal Year: 2024, Volume and Issue: 2(1)

Published: Nov. 21, 2024

Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice not readily infected by the ancestral strains because differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibility varies. Knowledge virus transmissibility from humans pet rodents is important for public health assess potential transmission home breeding selling facilities. this study, we assessed sensitivity guinea pigs gerbils isolated humans, found that susceptible SARS-CoV-2, but not. Pet sellers often display hamsters with high same area gerbils, so caution should be exercised during COVID-19 outbreaks.

Language: Английский

Translating insights into therapies for Long Covid DOI Open Access
Annukka A.R. Antar, Andrea L. Cox

Science Translational Medicine, Journal Year: 2024, Volume and Issue: 16(773)

Published: Nov. 13, 2024

Long Covid is defined by a wide range of symptoms that persist after the acute phase severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly reported include fatigue, weakness, postexertional malaise, and cognitive dysfunction, with many other reported. Symptom range, duration, severity are highly variable partially overlap myalgic encephalomyelitis/chronic fatigue post-acute infectious syndromes, highlighting opportunities to define shared mechanisms pathogenesis. Potential diverse, including persistence viral reservoirs, dysregulated immune responses, direct damage tissues targeted SARS-CoV-2, inflammation driven reactivation latent infections, vascular endothelium activation or subsequent thromboinflammation, autoimmunity, metabolic derangements, microglial activation, microbiota dysbiosis. The heterogeneity baseline characteristics people Covid, as well varying states immunity therapies given at time infection, have made etiologies difficult determine. Here, we examine progress on preclinical models for review being in clinical trials, need large human studies further development better understand Covid. Such will inform trials treatments benefit those living this condition.

Language: Английский

Citations

4
Animal Models for Long COVID: Current Advances, Limitations, and Future Directions DOI
Yu Zhang, Huan Chen, Yumeng Li

et al.

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(2)

Published: Feb. 1, 2025

ABSTRACT Long COVID (LC) represents a chronic, systemic, and often disabling condition that poses significant ongoing threat to public health. Foundational scientific studies are needed unravel the underlying mechanisms, with ultimate goal of developing effective preventative therapeutic strategies. Therefore, there is an urgent demand for animal models can accurately replicate clinical features LC. This review integrates epidemiological data summarize pathological changes in extrapulmonary systems involved Additionally, it critically examines capacity existing models, including nonhuman primates, genetically modified mice, Syrian hamsters, exhibit enduring postinfection symptoms align human manifestations, identifies key areas requiring further development. The objective offer insights will aid development next‐generation thereby accelerating our understanding how acute respiratory viral infections transition into chronic conditions, ensuring preparedness future pandemics.

Language: Английский

Citations

0
Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies DOI Creative Commons

Jingyi Dai,

Feihong HE,

Qian Chen

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Animal models are indispensable for unraveling the mechanisms underlying post-acute sequelae of COVID-19 (PASC). This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findings. Despite limited number studies post-COVID conditions, particularly those extending beyond three months, these provide valuable insights. Three hallmark features PASC-lung fibrosis, hyperglycemia, and neurological sequelae-have been successfully replicated paving way mechanistic discoveries future medical interventions. Although most have reported conditions within 14-60 days post-infection, they still offer critical reference long-term research. also explores potential persisting immune misfiring, a key factor chronicity PASC symptoms. Moreover, challenges modeling discussed, including genetic diversity inbred strains difficulties accurately identifying PASC-affected individuals. To address issues, we propose methodological improvements, such as comparing individual parameters control averages incorporating genetically diverse populations like collaborative cross models. These strategies will enhance identification characterization endotypes studies. By integrating findings from manifestations PASC, can more insights into its support development effective therapeutic strategies. Finally, emphasize urgent need longitudinal to fully uncover driving guide interventions mitigate public health impact.

Language: Английский

Citations

0
A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection DOI Creative Commons

Haowen Qiao,

Yafei Qu,

Lingxi Qiu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Abstract The coronavirus disease of 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), remains a major health issue after nearly 7 millions death toll in last four years. As world is recovering with improving vaccines and antiviral treatments, alarming rate long-COVID, or Post-acute Sequelae COVID-19 (PASC), calls for further investigations. Among list symptoms associated multi-organ dysfunctions, neurological complications are particularly intriguing, yet underlying mechanisms remain elusive. With recently developed mouse adapted SARS-CoV-2 stain, we now able to model mild COVID infection C57BL/6 mice study chronic immune responses subsequent damages different organs long viruses clearly naturally body. More specifically, found adult C57BL/6J impairments, including behavior changes related sensorimotor coordination, depression- anxiety-like behaviors, inflammation multiple lung, liver brain, which persisted over at least 4 weeks even infection. Therefore, this can be used explopred PASC, as well potential intervention therapeutic approaches.

Language: Английский

Citations

0
Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not DOI Creative Commons
Kiyoko Iwatsuki‐Horimoto, Maki Kiso,

Mutsumi Ito

et al.

npj Viruses, Journal Year: 2024, Volume and Issue: 2(1)

Published: Nov. 21, 2024

Syrian hamster are sensitive to SARS-CoV-2 and widely used as an animal model of COVID-19. In contrast, mice not readily infected by the ancestral strains because differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Thus, even among rodents, susceptibility varies. Knowledge virus transmissibility from humans pet rodents is important for public health assess potential transmission home breeding selling facilities. this study, we assessed sensitivity guinea pigs gerbils isolated humans, found that susceptible SARS-CoV-2, but not. Pet sellers often display hamsters with high same area gerbils, so caution should be exercised during COVID-19 outbreaks.

Language: Английский

Citations

0