Identifying potential therapeutic targets for prostate cancer with mediating role in tumor immunity

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Background Prostate cancer (PCa) is a leading malignancy with rising global incidence, posing significant challenges in treatment. The immunosuppressive tumor microenvironment (TME) CRPC major barrier to effective immunotherapy. Identifying therapeutic targets that modulate the immune response within TME crucial for advancing PCa Materials and Methods In this study, we employed Mendelian randomization (MR) investigate causal relationships between gene expression of blood proteins risk. We utilized cis-eQTL data from eQTLGen Consortium cell phenotype NHGRI-EBI GWAS Catalog. Our analysis included discovery validation cohorts, totaling over 800,000 individuals. Colocalization was performed confirm genetic associations, mediation MR used explore mediating role immunity. Drug prediction molecular docking were applied assess potential identified as druggable candidates. Results 557 associated cohort, 86 remaining an independent cohort. Mediation revealed nine mediated impact cells on PCa. confirmed causality five proteins, which further supported by phenome-wide association studies (PheWAS) protein-protein interaction (PPI) networks. Molecular demonstrated strong binding affinity drugs these targets. Conclusions This study drug prostate response. These may expedite development personalize medicine, potentially enhancing treatment efficacy reducing side effects.

Language: Английский

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Research hotspots and frontiers in the tumor microenvironment of colorectal cancer: a bibliometric study from 2014 to 2024

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 5, 2025

Background Colorectal cancer (CRC) is the second leading cause of deaths globally, which poses a heavy burden on our healthcare and economy. In recent years, increasing researches suggest that tumor microenvironment (TME) influences onset, progression, metastasis, treatment. This has become popular direction for researching attacking cancer. However, to date, there no bibliometric analysis colorectal from 2014 2024. study aims provide comprehensive picture current research status, hotspots, future trends in this field perspective. Methods study, publications about 2024 were searched based Web Science Core Collection database. Then we analyzed visualized data using CiteSpace, VOSviewer, bibliometrix package, Microsoft Excel 2019. Results A total 748 included number entered period rapid growth after China United States are major collaboration centers field. Elkord, Eyad most prolific author, Frontiers Immunology journal published papers TME CRC. addition, keyword cluster showed immune checkpoint inhibitors, cancer-associated fibroblasts, macrophage polarization, intestinal microbiota, liver drug resistance, scRNA-seq, etc. may be hotspots Conclusions developmental stage, strengthening international cooperation can help drive forward. The main components signaling TME, CRC immunotherapy, new techniques hot directions domain. Our findings will scholars with an up-to-date perspective state research,

Language: Английский

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Exploring the Role of Cellular Interactions in the Colorectal Cancer Microenvironment

Journal of Immunology Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Colorectal cancer (CRC) stands as one of the tumors with globally high incidence and mortality rates. In recent years, researchers have extensively explored role tumor immune microenvironment (TME) in CRC, highlighting crucial influence cell populations driving progression shaping therapeutic outcomes. The TME encompasses an array cellular noncellular constituents, spanning cells, myeloid tumor-associated fibroblasts, among others. However, composition within is highly dynamic, evolving throughout different stages progression. These shifts subpopulation proportions lead to a gradual transition response, shifting from early antitumor growth late-stage environment that supports survival. Therefore, it further investigate understand complex interactions various TME. this review, we explore key components varying origins, subpopulations shared elements CRC TME, examining their interconnections critical considerations for developing personalized precise immunotherapy strategies.

Language: Английский

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Application of a single-cell-RNA-based biological-inspired graph neural network in diagnosis of primary liver tumors

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 1, 2024

Language: Английский

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The Role of T Lymphocyte Subsets in Breast Cancer

Journal of Biosciences and Medicines, Journal Year: 2024, Volume and Issue: 12(12), P. 249 - 260

Published: Jan. 1, 2024

Language: Английский

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