Stem Cell Therapy for Diseases of Livestock Animals: An In-Depth Review

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 67 - 67

Published: Jan. 17, 2025

Stem cells are unique, undifferentiated that have the ability to both replicate themselves and develop into specialized cell types. This dual capability makes them valuable in development of regenerative medicine. Current stem research has widened their application therapy, drug discovery, reproductive cloning animals, models for various diseases. Although there substantial studies revealing treatment human degenerative diseases using cells, this is yet be explored livestock animals. Many species such as mastitis, laminitis, neuromuscular disorders, autoimmune diseases, some debilitating not covered completely by existing drugs can improved different types like embryonic adult induced pluripotent cells. review mainly focuses on use disease In addition mentioned, potential helpful wound healing, skin genetic disorders. article explores from sources therapy also role conservation endangered well model preparation. Moreover, future perspectives challenges associated with discussed. Overall, transformative impact sector comprehensively studied which will help researchers design work related

Language: Английский

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Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 3, 2025

Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers promising alternative, leveraging its immunomodulatory, neuroprotective, regenerative capabilities. This review provides an in-depth analysis MSC mechanisms action, including regulation, promotion remyelination, neuroregeneration. It examines preclinical studies trials evaluating efficacy, safety, limitations in various MS phenotypes. Special attention given challenges delivery routes, dosing regimens, integrating MSCs with conventional therapies. By highlighting advancements ongoing challenges, this underscores potential revolutionize treatment, paving way for personalized combinatory therapeutic approaches.

Language: Английский

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Effects of Repetitive Transcranial Magnetic Stimulation on Tumor Necrosis Factor Alpha in Neuropsychological Disorders: A Systematic Review and Meta‐Analysis

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

ABSTRACT Introduction: Repetitive transcranial magnetic stimulation (rTMS) shows promise in treating neuropsychological disorders. This systematic review and meta‐analysis investigated the effects of rTMS on inflammatory cytokines brain‐derived neurotrophic factor (BDNF) under these conditions. Method: We searched five electronic databases for relevant studies. Twelve studies (six randomized controlled trials [RCTs] six cohort studies) were included review, with RCTs meta‐analysis. The primary outcome was tumor necrosis factor‐alpha (TNF‐α) levels, secondary outcomes including interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β), high‐sensitivity C‐reactive protein (hs‐CRP), interferon‐gamma (IFN‐γ), BDNF. Results: Meta‐analysis revealed a significant decrease TNF‐α levels after (weighted mean difference [WMD]: −6.65, 95% confidence interval [CI]: −10.47–2.83, p < 0.05), greater associated longer interventions. No change found IL‐6 levels. BDNF increased significantly (WMD: 7.97, CI: 2.8–13.15, 0.05). Qualitative synthesis indicated consistent reductions IL‐1β. High heterogeneity observed some analyses. Conclusion: may exert therapeutic disorders partly through modulating neuroinflammation promoting neuroplasticity. However, high study limitations necessitate larger, more standardized clinical to confirm explore their significance.

Language: Английский

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Immunological and protective evaluation of purE/purK gene-deletion mutant of Brucella melitensis M5 strain

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107308 - 107308

Published: Jan. 1, 2025

Language: Английский

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Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Background Posttraumatic stress disorder (PTSD) commonly cooccurs with traumatic brain injury (TBI) in military populations and is a significant predictor of poor long-term outcomes; however, it unclear to what extent specific biological variables are associated comorbidity. This PROSPERO-registered systematic review evaluates the current body literature on genetic peripheral biomarkers comorbid TBI PTSD. Methods Searches were conducted four databases (PubMed, PsycInfo, PTSDPubs, Scopus). We included published studies examining differences among civilian, military, veteran participants both PTSD compared those alone as well as, some cases, healthy controls. Data extracted from evidence quality was assessed. Results Our final analysis 16 studies, majority which based data active duty participants. The results suggest that multiple gene variants likely contribute cumulative risk TBI. An elevated circulating level pro-inflammatory cytokine IL-6 most consistently replicated blood-based indicator illness, mTBI alone. Conclusion Several protein markers cellular inflammation appear be promising indicators chronic pathology Additional research needed determine how such factors indicate, predict, comorbidity they represent viable targets for development novel diagnostic tools therapeutic interventions.

Language: Английский

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The Mechanism of Warm Bile Soup on Circulating Ischemic Vertigo Was Investigated Based on Network Pharmacology

Traditional Chinese Medicine, Journal Year: 2025, Volume and Issue: 14(01), P. 462 - 469

Published: Jan. 1, 2025

Language: Английский

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Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study

Oral, Journal Year: 2025, Volume and Issue: 5(1), P. 19 - 19

Published: March 13, 2025

Background/Objectives: Bioactive materials are gaining increased popularity as of choice for pulpal regeneration. A similar trend is emerging with root repair materials; however, there a significant gap in the literature about cementogenic ability bioceramic on periodontal ligament cells. The aim present study was to investigate effect (Biodentine and Bio-C Repair) cementogenesis potential stem cells (PDLSCs). Methods: PDLSCs were isolated using enzymatic digestion approach from sound extracted teeth. Material extracts prepared rubber discs immersed fresh growth medium 24 h at 37 °C. Reverse transcription–quantitative polymerase chain reaction (RT-qPCR) used detect mRNA expression levels markers cementum protein 1 (CEMP1), Cementum attachment (CAP), pathway transforming factor β1(TGF-β1), bone morphogenic 2 (BMP2), inflammatory marker IL-6. Results: Both showed significantly higher gene expressions when compared control groups. Repair Biodentine, except TGF-β1 expression, where both exhibited results. Conclusions: demonstrated Biodentine under tested conditions. Further vivo studies deemed necessary translate findings this into clinical practice.

Language: Английский

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Emerging Insights into Brain Inflammation: Stem-Cell-Based Approaches for Regenerative Medicine

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3275 - 3275

Published: April 1, 2025

Neuroinflammation is a complex immune response triggered by brain injury or pathological stimuli, and highly exacerbated in neurodegenerative diseases. It plays dual role the central nervous system, promoting repair acute stages while aggravating disease progression contributing to neuronal loss, synaptic dysfunction, glial dysregulation chronic phases. Inflammatory responses are mainly orchestrated microglia infiltrated monocytes, which, when dysregulated, not only harm existing neurons, but also impair survival differentiation of neural stem progenitor cells affected regions. Modulating neuroinflammation crucial for harnessing its protective functions minimizing detrimental effects. Current therapeutic strategies focus on fine-tuning inflammatory through pharmacological agents, bioactive molecules, cell-based therapies. These approaches aim restore homeostasis, support neuroprotection, promote regeneration various neurological disorders. However, animal models sometimes fail reproduce human-specific brain. In this context, stem-cell-derived provide powerful tool study neuroinflammatory mechanisms patient-specific physiologically relevant context. facilitate high-throughput screening, personalized medicine, development targeted therapies addressing limitations traditional models, paving way more effective treatments.

Language: Английский

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Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment

Frontiers in Cellular Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 7, 2025

Stroke is characterized with high morbidity, mortality and disability all over the world, one of its core pathologies blood-brain barrier (BBB) dysfunction. BBB plays a crucial physiological role in protecting brain tissues maintaining homeostasis central nervous system (CNS). dysfunction serves as key factor development cerebral edema, inflammation, further neurological damage stroke patients. Currently, stem cells their derived exosomes have shown remarkable potential repairing damaged improving function after stroke. Stem repair integrity through anti-inflammatory, antioxidant, angiogenesis regulation intercellular signaling mechanisms, while cell-derived exosomes, natural nanocarriers, enhance therapeutic effect by carrying active substances such proteins, RNAs miRNAs. This review will present latest research advances treatment, well challenges cell source, transplantation timing, dosage, route administration clinical application, aiming to discuss mechanisms for proposes future directions. are expected provide new strategies early diagnosis precise treatment stroke, promote breakthroughs field

Language: Английский

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Effects of dietary supplementation with different amounts of Lycium ruthenicum (black goji berry) branch roughage on plasma biochemical indices and rumen microflora of sheep

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

This study aimed to evaluate the effects of dietary supplementation with roughage derived from black goji berry (Lycium ruthenicum) branches on plasma biochemical indices, and rumen microbiota in sheep. Forty male F1 lambs Dupo×Hu sheep crossbreeds, approximately 4 months age similar body weight (29.58 ± 2.06 kg) good health, were selected randomly divided into four groups (n = 10 per group). The control group was fed a full-mixed pelleted ration, experimental received same diet supplemented 10% (H1), 20% (H2) or 30% (H3) L. ruthenicum branch roughage. addition different amounts feed significantly increased apparent digestibility neutral detergent fiber, antioxidant immune indices without negative liver function. Additionally, relative abundance gut bacteria NK4A214_group Oscillospiraceae family linearly quadratically amount added diets. findings suggest that bioactive components (e.g., flavonoids, terpenoids, organic acids) may strengthen nutrient performance by altering type associated fiber digestion immunoregulation. Addition 20-30% fodder remarkably improved growth overall health.

Language: Английский

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