Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 859 - 859
Published: Feb. 28, 2025
Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs the microbiome and barrier, emphasizing dysbiosis increased permeability. UPFs, characterized by high content of synthetic additives emulsifiers, low fiber content, are associated with decrease microbial diversity, lower levels beneficial bacteria like Akkermansia muciniphila Faecalibacterium prausnitzii, an increase pro-inflammatory microorganisms. These alterations community contribute to persistent inflammation, which various chronic disorders including metabolic syndrome, irritable bowel type 2 diabetes, colorectal cancer. In addition, may alter gut-brain axis, potentially affecting cognitive function mental health. Dietary modifications incorporating fiber, fermented foods, probiotics can help mitigate effects UPFs. Furthermore, public needs stricter regulations for banning along well-defined labels. Further studies necessary elucidate mechanisms connecting systemic illnesses, thereby informing evidence-based dietary guidelines.
Language: Английский
Citations
2Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422
Published: Feb. 10, 2025
The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.
Language: Английский
Citations
1Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 14, 2025
Hepatocellular carcinoma (HCC) is the most frequently occurring type of liver tumor and considered one common primary malignant neoplasms. The prognosis for HCC dismal because its complicated etiology high level medication resistance. Immunotherapy presently regarded as effective therapeutic options HCC; nevertheless, disturbance intestinal flora, immunotherapy shows low antitumor efficacy. An increasing body research indicates that particularly Akkermansia muciniphila ( A. ), vital treatment tumors. Studies have demonstrated diminished effectiveness in cancer patients associated with a reduction levels, suggesting levels significantly enhance efficacy immunotherapy. functions gut probiotic can treat prevent wide range illnesses, including cancer. Consequently, preserving abundance enough to lower danger developing disorders. In this review, we critically evaluate current on , focus biological properties functions. different illnesses treats were then discussed, way it works This review aims give novel plan well theoretical foundation improving
Language: Английский
Citations
1Unlocking the Microbial Symphony: The Interplay of Human Microbiota in Cancer Immunotherapy Response
Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 813 - 813
Published: Feb. 26, 2025
The emergence of cancer immunotherapy has revolutionized treatment, offering remarkable outcomes for patients across various malignancies. However, the heterogeneous response to underscores necessity understanding additional factors influencing treatment efficacy. Among these factors, human microbiota garnered significant attention its potential role in modulating immune response. Body: This review explores intricate relationship between and immunotherapy, highlighting recent advances mechanisms underlying microbial influence on outcomes. Insights into microbiome's impact not only deepen our pathogenesis but also hold promise personalized therapeutic strategies aimed at optimizing patient
Language: Английский
Citations
0The Role of TMAO in the Development of HCC by Activating the NLRP3 Inflammasome
Hans Journal of Biomedicine, Journal Year: 2025, Volume and Issue: 15(02), P. 395 - 401
Published: Jan. 1, 2025
Language: Английский
Citations
0Oxidative Stress, Gut Microbiota, and Extracellular Vesicles: Interconnected Pathways and Therapeutic Potentials
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3148 - 3148
Published: March 28, 2025
Oxidative stress (OS) and gut microbiota are crucial factors influencing human health, each playing a significant role in the development progression of chronic diseases. This review provides comprehensive analysis complex interplay between these two factors, focusing on how an imbalance reactive oxygen species (ROS) antioxidants leads to OS, disrupting cellular homeostasis contributing range conditions, including metabolic disorders, cardiovascular diseases, neurological cancer. The microbiota, diverse community microorganisms residing gastrointestinal tract, is essential for regulating immune responses, pathways, overall health. Dysbiosis, composition, closely associated with inflammation, dysfunction, various highlights influences influenced by complicating pathophysiology many conditions. Furthermore, emerging evidence has identified extracellular vesicles (EVs) as critical facilitators crosstalk OS microbiota. EVs also play signaling host tissues, modulating processes. function holds promise targeted therapies aimed at restoring microbial balance mitigating OS. Personalized therapeutic approaches, probiotics, antioxidants, fecal transplantation-based strategies, can be used address OS-related diseases improve health outcomes. Nonetheless, further research needed study molecular mechanisms underlying interactions potential innovative interventions offer novel strategies managing enhancing
Language: Английский
Citations
0Investigating the Interaction Between Tangeretin Metabolism and Amelioration of Gut Microbiota Disorders Using Dextran Sulfate Sodium-Induced Colitis and Antibiotic-Associated Diarrhea Models
Current Research in Food Science, Journal Year: 2025, Volume and Issue: unknown, P. 101049 - 101049
Published: April 1, 2025
Dysregulation of gut microbiota homeostasis can lead to various health issues. In this study, we investigated the effects tangeretin (TAN) on in a mouse model (C57BL/6J) disease, specifically focusing dextran sulfate sodium (DSS)-induced colitis and antibiotic-associated diarrhea through vitro fermentation intestinal bacteria. Our results demonstrated that TAN effectively improved diversity structure disordered microbiota, increasing levels beneficial bacteria such as Lachnospiraceae Bacteroidaceae, while decreasing harmful Enterococcaceae Pseudomonadaceae. Additionally, enhanced production short-chain fatty acids (SCFAs) microbial communities. Moreover, metabolism by microorganisms yielded two new metabolites, which exhibited an inverse-conjugate (deconjugate) role, leading more functional substances with high bioactivity. These findings provide scientific basis for potential use prebiotic regulate microbiota.
Language: Английский
Citations
0Obesity and Cancer: Excess Body Fat as a Risk Factor in Carcinogenesis; Consequences Across Human Body Systems and Significance for Associated Medical Specialties
European Journal of Medical and Health Research, Journal Year: 2025, Volume and Issue: 3(2), P. 122 - 135
Published: March 23, 2025
Obesity is a known risk factor for various cancers, influencing carcinogenesis through metabolic, hormonal, and inflammatory pathways. Excess adiposity leads to insulin resistance, chronic inflammation, hormonal imbalances, all of which contribute tumor development. increases the cancers in endocrine system (e.g., thyroid, pancreatic, adrenal) due resistance altered hormone levels. In reproductive system, it raises breast, ovarian, endometrial, prostate dysregulation inflammation. also linked digestive including esophageal, liver, colorectal metabolic dysfunction The role obesity lung cancer remains debated, but changes may influence progression. contributes hematologic such as leukemia, by altering immune function promoting Other systems show varying associations with risk. Key mechanisms include dysregulation, epigenetic changes, elevated insulin/IGF-1, promote growth. Early detection imaging biomarkers, along lifestyle diet, exercise) pharmacologic treatments metformin, GLP-1 agonists), can reduce improve outcomes. Personalized treatment obese patients requires adjustments surgery, chemotherapy, radiotherapy, immunotherapy. This review explores obesity’s association across body systems, overviews contributing carcinogenesis, summarizes clinical public health implications, screening, prevention, treatment, policy interventions.
Language: Английский
Citations
0Microfluidic Gastrointestinal Cell Culture Technologies—Improvements in the Past Decade
Biosensors, Journal Year: 2024, Volume and Issue: 14(9), P. 449 - 449
Published: Sept. 19, 2024
Gastrointestinal cell culture technology has evolved in the past decade with integration of microfluidic technologies, bringing advantages greater selectivity and cost effectiveness. Herein, these technologies are sorted into three categories, namely cell-culture insert devices, conventional 3D-printed devices. Each category is discussed brief improvements also here. Introduction different companies applications derived from each provided to encourage uptake. Subsequently, future perspectives integrating microfluidics trending topics like stool-derived vitro communities gut-immune-tumor axis investigations discussed. Insights on modular its implications gastrointestinal cultures Future point-of-care (POC) relations devices In conclusion, this review presents an introduction platform insight contribution cultures.
Language: Английский
Citations
2Dysbiosis in Human Urinary Microbiota May Differentiate Patients with a Bladder Cancer
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10159 - 10159
Published: Sept. 21, 2024
Recent interest in noninvasive diagnostic approaches has highlighted the potential of urinary microbiota as a novel biomarker for bladder cancer. This study investigated 30 cancer patients and 32 healthy controls using specific NGS protocol that sequences eight hypervariable regions 16S rRNA gene, providing detailed insights into composition. The relative abundance microbial compositions urine samples from was analyzed across various taxonomic levels. No notable differences were at phylum, class, order, family At genus level, 53% detected genera represented either or controls. Microbial diversity significantly lower patients. differential analysis identified five genera, Rhodanobacter, Cutibacterium, Alloscardovia, Moryella, Anaeroglobus, more abundant Notably, Rhodanobacter present 20 but absent Conversely, 40 including Lactobacillus, Propionibacterium, Bifidobacterium, exhibited reduced These findings suggest some may serve biomarkers cancer, highlighting need further research to explore their roles disease pathogenesis applications diagnostics therapeutics.
Language: Английский
Citations
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