Impact of exercise on cancer: mechanistic perspectives and new insights DOI Creative Commons

Feng Ye,

Xingting Feng,

Renwen Wan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

This review critically evaluates the substantial role of exercise in enhancing cancer prevention, treatment, and patient quality life. It conclusively demonstrates that regular physical activity not only reduces risk but also significantly mitigates side effects therapies. The key findings include notable improvements fatigue management, reduction cachexia symptoms, enhancement cognitive functions. Importantly, elucidates profound impact on tumor behavior, modulation immune responses, optimization metabolic pathways, advocating for integration into standard oncological care protocols. refined abstract encourages further exploration application as a pivotal element management.

Language: Английский

Exploring CX3CR1 as a prognostic biomarker and immunotherapeutic target in sarcoma DOI Creative Commons
Tengfei Li, Xun Li,

Pengcheng Kang

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 53, P. 102283 - 102283

Published: Jan. 20, 2025

Language: Английский

Citations

0
Redefining bladder cancer treatment: innovations in overcoming drug resistance and immune evasion DOI Creative Commons
Peng Huang, Jie Wang,

Zongze Yu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Bladder cancer is one of the most common malignancies urinary system and has always presented great challenges in treatment due to its intricate biological features high recurrence rates. Although developments were achieved immunotherapy targeted therapies within last decade, therapeutic outcomes for a number patients remain unsatisfactory, particularly as long-term efficacy. Review discusses molecular mechanisms developed during process bladder progression: genetic epigenetic alterations, dynamics tumor microenvironment (TME), dysregulation abnormal activation various signaling pathways—all contributing resistance. It mutation, especially both low- high-grade tumors, that, alongside modifications, plays considerable role aggressiveness drug TME, comprising cancer-associated fibroblasts (CAFs), immunosuppressive cells, different components extracellular matrix (ECM), orchestrates setting that fosters growth immune evasion confers resistance on any regime might be used. The review also provides an overview PI3K/AKT MAPK pathways progression development against them. Further, it immunotherapy, including those involving checkpoint inhibitors. Other promising approaches include new strategies target not only but checkpoints combination therapies. This aims contribute elaboration more effective personalized by fully understanding underlying involved cancer.

Language: Английский

Citations

0
Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib DOI Creative Commons
Menghui Wang, Yueheng Li, Junhui Su

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 11, 2025

Many cases of advanced hepatocellular carcinoma (HCC) are resistant to the widely used drug sorafenib, which worsens prognosis. While many studies have explored how acquired resistance emerges during exposure, mechanism underlying primary before treatment still remain elusive. Single-cell lineage tracing and RNA sequencing were performed identify sorafenib-resistant lineages in HCC. Differential gene expression analysis was employed biomarkers drug-resistant cells. Cell viability colony formation assays adopted assess involvement S100A14 on sorafenib resistance. Co-immunoprecipitation (CO-IP) mass spectrometry conducted uncover downstream targets regulatory mechanisms sorafenib. In vivo mouse xenograft experiments carried out effect or its interacting protein glutaminase (GLS) identified a cluster cells, S100A14, Ca2+-binding protein, determined be critical biomarker for Knockdown significantly increases sensitivity HCC Mechanistically, binds GLS blocks phosphorylation at residues Y308 S314, turn inhibits ubiquitination subsequent degradation. By stabilizing GLS, reduces oxidative stress thereby antagonizing sorafenib-induced apoptosis. Inhibiting improved efficacy against tumors vivo. Our results demonstrate that plays pivotal role promoting by reduce stress, acts as potential therapeutic target enhance patients.

Language: Английский

Citations

0
Impact of exercise on cancer: mechanistic perspectives and new insights DOI Creative Commons

Feng Ye,

Xingting Feng,

Renwen Wan

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

This review critically evaluates the substantial role of exercise in enhancing cancer prevention, treatment, and patient quality life. It conclusively demonstrates that regular physical activity not only reduces risk but also significantly mitigates side effects therapies. The key findings include notable improvements fatigue management, reduction cachexia symptoms, enhancement cognitive functions. Importantly, elucidates profound impact on tumor behavior, modulation immune responses, optimization metabolic pathways, advocating for integration into standard oncological care protocols. refined abstract encourages further exploration application as a pivotal element management.

Language: Английский

Citations

2