Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression DOI Creative Commons
Jialiu Luo, Cong Zhang, Deng Chen

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 18, 2024

Sepsis is a major medical problem which causes millions of deaths worldwide every year. The host immune response in sepsis characterized by acute inflammation and simultaneous state immunosuppression. In the later stage sepsis, immunosuppression crucial factor that increases susceptibility septic patients to secondary infection mortality. It T cell exhaustion, excessive production anti-inflammatory cytokines, hyperproliferation suppressor cells aberrant expression checkpoint molecules. immunoglobulin mucin domain 3 (Tim-3), an molecule, found on surface various cells, including macrophages, NK NKT cells. There are four different ligands for Tim-3, accumulating evidence indicates Tim-3 its play role regulating dysfunction during sepsis. Anti-Tim-3 antibodies have been applied field cancer immunotherapy achieved positive therapeutic effects some clinical trials. However, efficacy blockade still controversial animal models These challenges highlight need deeper understanding signaling This review examines comprehensive effect development sepsis-induced blockade.

Language: Английский

Enteroviruses Activate Cellular Innate Immune Responses Prior to Adaptive Immunity and Tropism Contributes to Severe Viral Pathogenesis DOI Creative Commons
Jonathan Coffman

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 870 - 870

Published: April 10, 2025

Numerous innate immune mechanisms have been shown to be activated during viral infections, including pattern recognition receptors (PRRs) functioning outside and inside the cell along with other sensors promoting production of interferon cytokines. Innate cells, NK NKT γδ T dendritic macrophages, even neutrophils, respond infections. Several humoral responses infections also identified. Adaptive immunity includes common cell-mediated (CMI) responses. Th1, Th2, Tfh CD4+ help activate cytotoxic lymphocytes (CTLs) promote class switching antiviral antibodies. Enteroviruses were induce tropism virus that was mediated through attachment proteins (VAPs) cellular directly related risk severe disease in a primary infection. include immunity, its delay underscores importance vaccination ameliorating or preventing pathogenesis.

Language: Английский

Citations

0
ITGB2 and ICAM3 predict increased survival of sepsis with decreased intercellular communication in cytotoxic CD8+ T cells DOI Creative Commons
Min Lei, Yaping Zhang, Yijin Yu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

Language: Английский

Citations

0
Association between Advanced lung cancer inflammation index and all- cause mortality in critically ill patients with sepsis: analysis of the MIMIC- IV database DOI Creative Commons
Lei Zhang, Mingcai Li, Jianfei Liu

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Background This study aimed to explore the association between advanced lung cancer inflammation (ALI) index and risk of mortality in critically ill patients with sepsis. Methods retrospective included 6489 sepsis from Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. The participants were grouped into four groups according ALI quartiles. outcome was in-hospital ICU mortality. Cox proportional hazards regression analysis restricted cubic spline used evaluate clinical outcomes Results A total (59.1% male) study. intensive care unit (ICU) 25.4% 19.0%, respectively. Multivariate showed that independently associated all-cause After confounders adjusting, an elevated had a significant hospital (adjusted hazard ratio, 0.990; 95% confidence interval, 0.985–0.996; P < 0.001) 0.991; 0.985–0.997; = 0.004). Restricted splines revealed non-linear patients. Conclusion Our indicates has However, further confirmation these findings necessitates larger prospective studies.

Language: Английский

Citations

0
Immunoredox model for interpretation and prediction of human diseases DOI
Young Jun Kim, Hyungdon Lee,

Sofian Abdul-Nasir

et al.

Molecular & Cellular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

Citations

0
Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression DOI Creative Commons
Jialiu Luo, Cong Zhang, Deng Chen

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 18, 2024

Sepsis is a major medical problem which causes millions of deaths worldwide every year. The host immune response in sepsis characterized by acute inflammation and simultaneous state immunosuppression. In the later stage sepsis, immunosuppression crucial factor that increases susceptibility septic patients to secondary infection mortality. It T cell exhaustion, excessive production anti-inflammatory cytokines, hyperproliferation suppressor cells aberrant expression checkpoint molecules. immunoglobulin mucin domain 3 (Tim-3), an molecule, found on surface various cells, including macrophages, NK NKT cells. There are four different ligands for Tim-3, accumulating evidence indicates Tim-3 its play role regulating dysfunction during sepsis. Anti-Tim-3 antibodies have been applied field cancer immunotherapy achieved positive therapeutic effects some clinical trials. However, efficacy blockade still controversial animal models These challenges highlight need deeper understanding signaling This review examines comprehensive effect development sepsis-induced blockade.

Language: Английский

Citations

2