Prediction of Hepatocellular Carcinoma Prognosis and Immunotherapy Response Using Mitochondrial Dysregulation Features

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(3)

Published: Feb. 1, 2025

ABSTRACT Hepatocellular carcinoma (HCC) is a major contributor to cancer‐related deaths globally. Although there have been improvements in identifying treating the disease, patient outcomes are still unfavourable because of significant variation HCC. Mitochondrial‐related genes (MRGs) crucial tumour metabolism, cell death and immune response, emerging as potential therapeutic targets. We analysed 2030 MRGs using TCGA, GEO HCCDB18 databases. Differentially expressed were identified edgeR limma, enrichment analysis was performed via clusterProfiler package. A prognostic model built machine learning algorithms evaluated LOOCV. Immune infiltration assessed with CIBERSORT, EPIC, MCPCounter TIMER algorithms, drug sensitivity CTRP PRISM datasets. MRG expression levels significantly associated worse HCC patients outperformed conventional clinical indicators response revealed that individuals at high risk exhibited weaker responses, characterised by reduced scores, elevated CD8+ T cells macrophages. Notably, high‐risk also displayed heightened susceptibility chemotherapy agents such paclitaxel irinotecan. Abnormal serves biomarker for prognosis. The developed accurately predicts disease progression can guide personalised treatment, especially chemotherapeutic therapies. Further validation broader samples needed.

Language: Английский

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Exploring the Potential of Mitochondria‐Targeted Drug Delivery for Enhanced Breast Cancer Therapy

International Journal of Breast Cancer, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Breast cancer stands as the utmost prevalent malignancy in women, impacting epithelial tissue of breast and often displaying resistance to effective treatment due its diverse molecular histological features. Current modalities may exhibit decreasing efficacy over time can lead disease progression. The mitochondria, a crucial organelle responsible for cellular metabolism energy supply, stand highly sensitive both heat reactive oxygen species, presenting an assuring target photodynamic photothermal therapies (PTTs) cure. employment nanodrug carriers combination deliveries holds promise addressing challenges related drug degradation off-target toxicity. By circumventing reticuloendothelial system, nanocarriers bolster drug's bioavailability at intended site ensure controlled codelivery multiple drugs, thereby maintaining normal pharmacokinetic features regular pharmacodynamic characteristics different therapeutic mechanisms. precision this innovative technology have revolutionized delivery, substantially enhancing effectiveness. In pursuit targeting mitochondrial modifications cells, various such therapy (PDT), PTT, chemodynamic (CDT) been explored. These improved efficiency mitochondria-targeted their advantageous properties minimal toxicity, noninvasiveness, reduced resistance, safer profile. Our review article provides exhaustive overview alterations environment BC, impact on BC development, potential targets treatment, nanotherapeutic approaches limitations these approaches.

Language: Английский

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Mitochondrial Dynamics Regulators in Cancer Metabolism and Progression

Mitochondrial Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Tumor Microenvironment Dynamics of Triple-Negative Breast Cancer Under Radiation Therapy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2795 - 2795

Published: March 20, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of characterized by the absence estrogen receptors (ER), progesterone (PR), and HER2 expression. While TNBC relatively less common, accounting for only 10–15% initial diagnosis, due to its nature, it carries a worse prognosis in comparison hormone receptor-positive counterparts. Despite significant advancements screening, treatment cancer, remains important public health burden. Following with chemotherapy, surgery, radiation, over 40% patients experience relapse within 3 years achieve least benefit from post-mastectomy radiation. The tumor microenvironment environment (TME) pivotal initiation, progression, immune evasion, resistance, prognosis. TME complex network that consists cells, non-immune soluble factors located region adjacent modulates therapeutic response differentially between TNBC. mechanisms underlying radiation resistance remain unclear, immunosuppressive has been implicated chemotherapeutic resistance. Radiation therapy (RT) known alter TME; however, changes elicited are poorly date, whether these contribute unknown. This review delves into distinct characteristics TME, explores how RT influences dynamics, examines radiosensitization, radioresistance, responses.

Language: Английский

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Mitochondrial Transfer: Therapeutic Implications for Energy Metabolism in Heart Failure

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107555 - 107555

Published: Dec. 1, 2024

Language: Английский

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