Aging and long COVID-19 syndrome: what’s new in 2023? DOI Open Access
Ray Marks

MOJ Gerontology & Geriatrics, Journal Year: 2023, Volume and Issue: 8(1), P. 9 - 14

Published: Feb. 22, 2023

Since 2019 that saw the onset of COVID-19 pandemic, its ongoing impact on many older adults remains a persistent public health concern, especially among those who report suffering from long or post-acute disease challenges. This presents data published largely since January 1 2023 this topic and concerning: Long COVID COVID-19, Older Adults, Post-Acute Outcomes, Prevention. Data show even though was discussed in 2021 at some length, it still relatively unchartered poorly understood which sizeable percentage adult survivors may experience delayed features breathing, movement, cognitive mental What causes observed perceived problems, what help to identify is risk, will reduce these unknown, but benefit insightful research extended observations possible.

Language: Английский

Post-COVID dysautonomias: what we know and (mainly) what we don’t know DOI
David S. Goldstein

Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(2), P. 99 - 113

Published: Jan. 11, 2024

Language: Английский

Citations

20
Cardiovascular autonomic dysfunction in “Long COVID”: pathophysiology, heart rate variability, and inflammatory markers DOI Creative Commons

Karina Carvalho Marques,

Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: Sept. 1, 2023

Long COVID is characterized by persistent signs and symptoms that continue or develop for more than 4 weeks after acute COVID-19 infection. Patients with experience a cardiovascular autonomic imbalance known as dysautonomia. However, the underlying pathophysiological mechanisms behind this remain unclear. Current hypotheses include neurotropism, cytokine storms, inflammatory persistence. Certain immunological factors indicate autoimmune dysfunction, which can be used to identify patients at higher risk of COVID. Heart rate variability imbalances in individuals suffering from COVID, measurement non-invasive low-cost method assessing modulation. Additionally, biochemical markers are diagnosing monitoring These improve understanding driving response its effects on sympathetic parasympathetic pathways nervous system. Autonomic may result lower heart variability, impaired vagal activity, substantial sympathovagal imbalance. New research subject must encouraged enhance long-term risks cause

Language: Английский

Citations

27
Whole-Body Cryostimulation in Post-COVID Rehabilitation for Patients with Obesity: A Multidisciplinary Feasibility Study DOI Creative Commons
Jacopo Maria Fontana, Angelo Alito, Paolo Piterà

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3092 - 3092

Published: Nov. 18, 2023

A post-COVID condition can reduce activity and quality of life, resulting in a significant socioeconomic health burden. Understanding its impact on patients' is important for the development personalized rehabilitation interventions. An independent association between obesity was found because complications comorbidities.Sixteen patients with symptoms (i.e., dyspnea, pain, poor sleep quality, muscle fatigue), admitted to Istituto Auxologico Italiano, Piancavallo (VB), Italy, were recruited four-week program including conventional exercise therapy, nutritional intervention, psychological support whole-body cryostimulation (WBC).All participants attended all sessions program. Anthropometric data showed statistically changes weight, waist circumference body mass index. Biochemical analyses reductions lipid inflammatory profiles. There improvement physical performance, reduction pain well-being.A multidisciplinary protocol WBC, designed condition, safe feasible. The overall improvements demonstrate that effective post COVID suggest use WBC could play role as booster programs.

Language: Английский

Citations

18
Nonallergic Rhinopathy: A Comprehensive Review of Classification, Diagnosis, and Treatment DOI
Fuad M. Baroody, Philippe Gevaert, Peter Smith

et al.

The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: 12(6), P. 1436 - 1447

Published: March 11, 2024

Language: Английский

Citations

6
People with Long Covid and ME/CFS Exhibit Similarly Impaired Balance and Physical Capacity: A Case-Case-Control Study DOI Creative Commons
Lawrence D. Hayes, Nilihan E. M. Sanal‐Hayes, Marie Mclaughlin

et al.

The American Journal of Medicine, Journal Year: 2023, Volume and Issue: 138(1), P. 140 - 147

Published: July 23, 2023

PurposePostural sway and physical capacity had not previously been compared between people with long COVID myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Therefore, this study determined postural in (∼16-month illness duration; n = 21) ME/CFS (∼16-year 20), vs age-matched healthy controls (n 20).MethodsPostural was during a 30-s static stand test. Physical using the Timed Up Go test 5 Times Sit to Stand Throughout, participants wore isoinertial measurement units.ResultsPostural worse (ie, greater) than controls, but different ME/CFS. Performance of were Of participants, 87% 13% exceeded threshold for muscle weakness test, respectively.ConclusionsThese data suggest that both have similarly impaired balance capacity. there is an urgent need interventions target ME/CFS, given current pandemic, COVID.

Language: Английский

Citations

15
Improving Neuropsychological Rehabilitation for COVID-19 Patients DOI Creative Commons
Catherine Widmann, Juliana Kolano, Martin Peper

et al.

Zeitschrift für Neuropsychologie, Journal Year: 2023, Volume and Issue: 34(2), P. 57 - 70

Published: May 24, 2023

Abstract: Cognitive sequelae after recovery from an initial COVID-19 disease are present in a subset of affected individuals, coalescing around several important issues such as effects age, severity, comorbidities, and other factors. Some neuropsychological symptoms appear more common among certain patient populations. Comorbidities may complicate assessment well. Hence, we need guideline-based evaluation to guide rehabilitation. Drawing the recent revision German National Guideline for Long- Post-COVID Syndrome current advances international guidance on assessment, this article provides practical scientifically informed recommendations individuals recovering coronavirus-related diseases.

Language: Английский

Citations

13
A murine model of post-acute neurological sequelae following SARS-CoV-2 variant infection DOI Creative Commons
Ankita Singh,

Awadalkareem Adam,

Aditi Aditi

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 3, 2024

Viral variant is one known risk factor associated with post-acute sequelae of COVID-19 (PASC), yet the pathogenesis largely unknown. Here, we studied SARS-CoV-2 Delta variant-induced PASC in K18-hACE2 mice. The virus replicated productively, induced robust inflammatory responses lung and brain tissues, caused weight loss mortality during acute infection. Longitudinal behavior studies surviving mice up to 4 months infection revealed persistent abnormalities neuropsychiatric state motor behaviors, while reflex sensory functions recovered over time. In brain, no detectable viral RNA minimal residential immune cell activation was observed Transcriptome analysis pathways, including humoral responses, complement, phagocytosis, gene expression levels ataxia telangiectasia, impaired cognitive function memory recall, neuronal dysfunction degeneration. Furthermore, maintained potent systemic T helper 1 prone cellular strong sera neutralizing antibodies against Omicron variants Overall, our findings suggest that recapitulates clinical symptoms reported long-COVID patients provides new insights into role factors pathogenesis.

Language: Английский

Citations

5
People with Long Covid and ME/CFS Exhibit Similarly Impaired Dexterity and Bimanual Coordination: A Case-Case-Control Study DOI Creative Commons
Nilihan E. M. Sanal‐Hayes, Lawrence D. Hayes, Marie Mclaughlin

et al.

The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 1, 2024

Abstract

Purpose

Dexterity and bimanual coordination had not previously been compared between people with long COVID Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Therefore, this study determined dexterity in (∼16 month illness duration; n=21) ME/CFS year n=20), versus age-matched healthy controls (n=20).

Methods

Dexterity, was using the Purdue pegboard test.

Results

The main findings of present investigation were that generally comparable for tests (p>0.556 d<0.36 pairwise comparisons). It is worth noting however, both these patient groups performed poorer Perdue test than (p<0.169 d>0.40

Conclusions

These data suggest have similarly impaired dexterity, coordination. there an urgent need interventions to target ME/CFS, given current pandemic, COVID.

Language: Английский

Citations

4
Proteomic Atlas of Post-COVID Sequelae DOI Creative Commons
Philipp S. Wild, Sepehr Golriz Khatami,

Rieke Baumkötter

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract The emergence of post-COVID sequelae (PCS) represents a global challenge. However, understanding biological mechanisms and the definition quantifiable risk factors remains limited. This study harnessed power predictive machine learning models to explore potential proteomics in predicting individual symptoms their collective manifestation as PCS. analysis utilized panel approximately 2900 proteins measured 495 COVID-19 patients. identified 235 unique associated with 21 distinct symptoms. Symptoms more closely linked by similar protein patterns tended co-occur frequently Six symptom clusters molecular pathway signatures were uncovered, metabolic inflammatory pathways prominently involved across several clusters. relevance specific for could be demonstrated explored objective, clinical tests, including cognitive somatic assessments, underlined relevance. Data from various modalities, pre-existing conditions, disease genetic susceptibility, revealed relevant relations that may contribute PCS heterogeneity. work underscores complex multifaceted nature It emphasizes need systematic approaches facilitate development targeted therapies treatment strategies.

Language: Английский

Citations

0
Using a Wearable Brain Activity Sensing Device in the Treatment of Long COVID Symptoms in an Open-Label Clinical Trial DOI Creative Commons
Ryan T. Hurt, Ravindra Ganesh, Darrell R. Schroeder

et al.

Journal of Primary Care & Community Health, Journal Year: 2025, Volume and Issue: 16

Published: March 1, 2025

Objective: This study evaluated the feasibility and satisfaction of using a wearable brain activity sensing device for stress reduction among patients experiencing Long COVID (LC). Patients Methods: with LC (N = 45) were invited to participate in an open-label pilot study. Participants asked use brain-sensing electroencephalogram (S-EEG) (Muse-S™) daily 90 days followed additional (180 total participation). Study enrollment began June 28, 2022, ended July 2023. Results: predominantly female (82%), white (96%), average age 47.6 (±12.5) years. At end treatment (90 days), cognition, sleep, self-efficacy, quality-of-life quality life improved ( P < .001 .04). In addition, anxiety significantly reduced .001). These significant changes persisted by end-of-study days). For .023) .033), change from baseline during follow-up was associated amount S-EEG usage. The survey indicated that very satisfied device, 97% planned continue it. Conclusion: Results suggest cognition LC, which is one main severe symptoms we see our clinic. it helped reduce anxiety. findings have important clinical implications as adjunct concurrent care includes pharmacotherapies.

Language: Английский

Citations

0