International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(8), P. 3707 - 3707
Published: April 14, 2025
The
AGE
(advanced
glycation
end-products)–RAGE
(receptor
for
AGE)
system
is
a
pro-inflammatory
pathway
that
contributes
to
the
pathogenesis
of
obesity
and
obesity-related
cardiovascular
disorders
(CVD).
Circulating
soluble
form
RAGE
(sRAGE)
has
been
suggested
as
potential
biomarker
CVD
related
obesity.
In
this
study,
we
aim
(1)
summarize
current
knowledge
about
role
in
onset
progression
CVD,
(2)
discuss
AGE–RAGE
promoting
linking
(3)
highlight
available
strategies
reducing
activation
associated
beneficial
effects.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 9881 - 9881
Published: June 8, 2023
Ageing
is
a
composite
process
that
involves
numerous
changes
at
the
cellular,
tissue,
organ
and
whole-body
levels.
These
result
in
decreased
functioning
of
organism
development
certain
conditions,
which
ultimately
lead
to
an
increased
risk
death.
Advanced
glycation
end
products
(AGEs)
are
family
compounds
with
diverse
chemical
nature.
They
non-enzymatic
reactions
between
reducing
sugars
proteins,
lipids
or
nucleic
acids
synthesised
high
amounts
both
physiological
pathological
conditions.
Accumulation
these
molecules
increases
level
damage
tissue/organs
structures
(immune
elements,
connective
brain,
pancreatic
beta
cells,
nephrons,
muscles),
consequently
triggers
age-related
diseases,
such
as
diabetes
mellitus,
neurodegeneration,
cardiovascular
kidney
disorders.
Irrespective
role
AGEs
initiation
progression
chronic
disorders,
reduction
their
levels
would
certainly
provide
health
benefits.
In
this
review,
we
overview
areas.
Moreover,
examples
lifestyle
interventions,
caloric
restriction
physical
activities,
may
modulate
AGE
formation
accumulation
help
promote
healthy
ageing.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 425 - 425
Published: March 30, 2024
Niacinamide
(or
nicotinamide)
is
a
small-molecule
hydrosoluble
vitamin
with
essential
metabolic
functions
in
mammalian
cells.
has
become
key
functional
ingredient
diverse
skincare
products
and
cosmetics.
This
plays
pivotal
role
NAD+
synthesis,
notably
contributing
to
redox
reactions
energy
production
cutaneous
Via
diversified
biochemical
mechanisms,
niacinamide
also
known
influence
human
DNA
repair
cellular
stress
responses.
Based
on
decades
of
safe
use
cosmetics,
recently
gained
widespread
popularity
as
an
active
which
aligns
the
“Kligman
standards”
skincare.
From
therapeutic
standpoint,
intrinsic
properties
may
be
applied
managing
acne
vulgaris,
melasma,
psoriasis.
cosmeceutical
been
widely
leveraged
multipurpose
antiaging
ingredient.
Therein,
it
was
shown
significantly
reduce
oxidative
stress,
inflammation,
pigmentation.
Overall,
through
multimodal
considered
partially
prevent
and/or
reverse
several
biophysical
changes
associated
skin
aging.
The
present
narrative
review
provides
multifactorial
insights
into
mechanisms
niacinamide’s
functions.
ingredient’s
evolving
critically
appraised,
strong
focus
at
play.
Finally,
novel
indications
potential
applications
dermal
fillers
alternative
injectable
formulations
were
prospectively
explored.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 1215 - 1229
Published: May 1, 2023
Abstract:
Of
the
human
organs,
skin
is
most
visible
one
that
displays
manifestations
of
ageing.
It
has
a
very
intricate
microanatomical
structure
and
performs
several
key
physiological
functions.
The
pathophysiology
cutaneous
ageing
characterized
by
deterioration
structural
stability
functional
integrity,
implying
continuous
reduction
in
maximal
function
reserve
capacity,
as
result
accumulating
damage
due
to
both
intrinsic
extrinsic
factors.
Elimination
unfavorable
expressions
associated
with
facial
patient
demand
aesthetic
dermatology.
Even
though
progress
been
made
nonsurgical
therapies
like
fillers
lasers,
non-invasive
interventions
using
care
products
designed
for
rejuvenation
at
an
early
stage
are
popular
accessible
solution
among
people.
In
this
review,
we
have
scrutinized
ageing-associated
changes
molecular,
cellular
tissue
levels.
To
optimize
process
towards
healthy
skin,
propose
integrated,
multilayer-targeted
intervention,
which
involves
topical
application
anti-ageing
formulations
from
outside
oral
supplementation
inside.
Additionally,
promising
naturally
derived
ingredients
reviewed
anti-aging
perspective.
Most
them
possess
various
bioactivities
may
contribute
development
mentioned
remedy.
Keywords:
barrier,
ageing,
causative
factors,
remedy,
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 19, 2024
In
this
narrative
review,
we
sought
to
provide
a
comprehensive
overview
of
the
mechanisms
underlying
cutaneous
senescence,
framed
by
twelve
traditional
hallmarks
aging.
These
include
genomic
instability,
telomere
attrition,
epigenetic
alterations,
loss
proteostasis,
impaired
macroautophagy,
deregulated
nutrient
sensing,
mitochondrial
dysfunction,
cellular
stem
cell
exhaustion,
altered
intercellular
communication,
chronic
inflammation,
and
dysbiosis.
We
also
examined
how
topical
interventions
targeting
these
can
be
integrated
with
conventional
aesthetic
medicine
techniques
enhance
skin
rejuvenation.
The
potential
combining
targeted
therapies
against
aging
minimally
invasive
procedures
represents
significant
advancement
in
medicine,
offering
personalized
effective
strategies
combat
reviewed
evidence
paves
way
for
future
advancements
underscores
transformative
integrating
scientifically
validated
into
practices.
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 18, 2024
The
most
recognizable
implications
of
tissue
aging
manifest
themselves
on
the
skin.
Skin
laxity,
roughness,
pigmentation
disorders,
age
spots,
wrinkles,
telangiectasia
or
hair
graying
are
symptoms
physiological
aging.
Development
senescent
phenotype
depends
interaction
between
cells
and
remodeling
skin’s
extracellular
matrix
(ECM)
that
contains
collagen
elastic
fiber.
Aging
changes
occur
due
to
combination
both
endogenous
(gene
mutation,
cellular
metabolism
hormonal
agents)
exogenous
factors
(ultraviolet
light,
environmental
pollutants,
unsuitable
diet).
However,
overproduction
mitochondrial
reactive
oxygen
species
(ROS)
is
a
key
factor
driving
senescence.
theories
have
disclosed
range
diverse
molecular
mechanisms
associated
with
senescence
body.
Theories
best
supported
by
evidence
include
protein
glycation,
oxidative
stress,
telomere
shortening,
cell
cycle
arrest,
limited
number
divisions.
Accumulation
ECM
damage
suggested
be
in
skin
Every
indicates
functional
morphological
change
may
used
as
biomarker
Senescence-associated
β
-galactosidase
(SA-β-gal),
inhibitors
(p16INK4a,
p21CIP1,
p27,
p53),
DNA
segments
chromatin
alterations
reinforcing
(DNA-SCARS),
senescence-associated
heterochromatin
foci
(SAHF),
shortening
telomeres
downregulation
lamina
B1
constitute
just
an
example
biomarkers
known
so
far.
also
assessed
non-invasively
through
measuring
fluorescence
advanced
glycation
end-products
(AGEs).
This
review
summarizes
recent
knowledge
pathogenesis
clinical
conditions
well
