Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16042 - 16042

Published: Nov. 7, 2023

Bronchial asthma is a heterogeneous disease characterized by persistent respiratory system inflammation, airway hyperreactivity, and airflow obstruction. Airway remodeling, defined as changes in wall structure such extensive epithelial damage, smooth muscle hypertrophy, collagen deposition, subepithelial fibrosis, key feature of asthma. Lung fibrosis common occurrence the pathogenesis fatal long-term asthma, it associated with severity resistance to therapy. It can thus be regarded an irreversible consequence asthma-induced inflammation remodeling. Asthma heterogeneity presents several diagnostic challenges, particularly distinguishing between chronic other pulmonary diseases disruption normal lung architecture functions, obstructive disease. The search for instruments that predict development structural lungs, components remodeling difficult. To overcome these significant efforts are being directed toward discovery investigation molecular characteristics biomarkers capable different types well disorders similar characteristics. main features bronchial etiology, pathogenesis, morphological asthma-associated successive stages one process will discussed this review. most murine models progression post-asthmatic also covered. mechanisms cellular players asthmatic described systematized review intended help new markers promising therapeutic targets prediction

Language: Английский

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A Holistic Approach for Ethics and Sustainability in the Food Chain: The Gateway to Oral and Systemic Health

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1224 - 1224

Published: April 17, 2024

Food production is a complex matter, affecting people’s lives, organizations’ profits, and the well-being of whole planet, has multifaceted ethical considerations surrounding its production, distribution, consumption. This paper addresses pressing need to confront challenges within food system, encompassing issues such as environmental sustainability, security, individual choices for better oral systemic health all individuals around globe. From agricultural practices global trade waste, implications are addressed across various domains, highlighting interconnectedness decision-making in industry. Central themes explored include dimensions methods, impact on ethics, role making ethically informed choices. Additionally, this considers spiritual physical significance food, particularly through lens gateway holistic well-being. Recognizing complexity mouth ecosystem, calls serious interventions legislation economics promote protocols techniques sustainability reasons. It emphasizes importance safety management systems, regulatory frameworks, quality standards. Moreover, underlines comprehensive approach address dilemmas moral values inherent industry policies, adopting precautionary principle frameworks. article finally aims serve call action stakeholders healthcare sector, prioritize practices, transparency, rearrange economic parameters, work towards more sustainable equitable system inner outer human all.

Language: Английский

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Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report

Allergy, Journal Year: 2023, Volume and Issue: 78(7), P. 1758 - 1776

Published: April 12, 2023

Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care asthma, they cannot be largely used primary care. There no validated or allergen immunotherapy (AIT) that can clinical practice. The digital transformation health (including mHealth) places patient at center system is likely to optimize practice allergy. Allergic Rhinitis its Impact on Asthma (ARIA) EAACI (European Academy Allergy Clinical Immunology) developed a Task Force aimed proposing patient-reported outcome measures (PROMs) as easily different purposes asthma. It first defined control should make bridge between practice, randomized controlled trials, observational real-life studies challenges. Using MASK-air app model, daily electronic combined symptom-medication score allergic diseases (CSMS) (e-DASTHMA), monthly questionnaire, was embedded strategy similar diabetes approach disease control. To mimic real-life, it secondly proposed quality-of-life including EQ-5D visual analogue scales bi-weekly RhinAsthma Patient Perspective (RAAP). potential implications management respiratory were proposed.

Language: Английский

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The Emerging Clinical Significance of the Red Cell Distribution Width as a Biomarker in Chronic Obstructive Pulmonary Disease: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(19), P. 5642 - 5642

Published: Sept. 25, 2022

There is an intense focus on the identification of novel biomarkers chronic obstructive pulmonary disease (COPD) to enhance clinical decisions in patients with stable and acute exacerbations (AECOPD). Though several local (airway) circulatory inflammatory have been proposed, emerging evidence also suggests a potential role for routine haematological parameters, e.g., red cell distribution width (RDW). We conducted systematic literature search PubMed, Web Science, Scopus, from inception April 2022, articles investigating diagnostic prognostic RDW COPD AECOPD. The risk bias was assessed using Joanna Briggs Institute Critical Appraisal Checklist. Significant associations between presence severity disease, outcomes (mortality, hospital readmission), other relevant parameters (right heart failure, arterial hypertension) were reported 13 out 16 studies (low 11 studies), 17 21 AECOPD studies). Pending further research, our review that might be useful, singly or combination diagnosis stratification (PROSPERO registration number: CRD42022348304).

Language: Английский

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Neuroinflammation in the Evolution of Motor Function in Stroke and Trauma Patients: Treatment and Potential Biomarkers

Current Issues in Molecular Biology, Journal Year: 2023, Volume and Issue: 45(11), P. 8552 - 8585

Published: Oct. 25, 2023

Neuroinflammation has a significant impact on different pathologies, such as stroke or spinal cord injury, intervening in their pathophysiology: expansion, progression, and resolution. involves oxidative stress, damage, cell death, playing an important role neuroplasticity motor dysfunction by affecting the neuronal connection responsible for control. The diagnosis of this pathology is performed using neuroimaging techniques molecular diagnostics based identifying measuring signaling molecules specific markers. In parallel, new therapeutic targets are being investigated via use bionanomaterials electrostimulation to modulate neuroinflammatory response. These novel diagnostic strategies have potential facilitate development anticipatory patterns deliver most beneficial treatment improve patients’ quality life directly skills. However, challenges remain be solved. Hence, goal study was review implication neuroinflammation evolution function trauma patients, with particular focus methods biomarkers aid clinicians diagnosis, treatment, therapy. A analysis strengths, weaknesses, threats, opportunities conducted, highlighting key faced coming years.

Language: Английский

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Correlation between Red Blood Cell Distribution Width and the Prognosis of Patients with Chronic Obstructive Pulmonary Disease

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 751 - 756

Published: Jan. 1, 2025

Language: Английский

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Smart lab-on-chip devices for healthcare

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 345 - 371

Published: Jan. 1, 2025

Language: Английский

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Oral Cavity is the Gateway to the Body: Role of Oral Health Professionals: A Narrative Review

Journal of the California Dental Association, Journal Year: 2023, Volume and Issue: 51(1)

Published: March 30, 2023

Background The oral cavity is the most important link between human body and external environment well-equipped to protect against invading pathogens. Emerging data on bidirectional relationship health severity of COVID-19 symptoms has prompted us reexamine our role as guardians - true gateway body. Recent studies have shown that microbiome a complex ecological system interactions its residents host cells influence disease. This narrative review elaborates oral-systemic connection from an standpoint discusses future professionals.Methods A PubMed literature search using keywords "Oral Microbiome Diseases" Health" for range ten years 2012-2022 was completed. Meta-Analyses, Reviews, Randomized Control Trials, Clinical books were included in search.Results yielded 6392 results 4287 results.Conclusion Oral professionals need be trained periodically appreciate recent advances this field.Practical Implications deeper understanding impact existing treatment modalities could expand preventing maintaining patients' overall health. Implementing point-of-care salivary diagnostics detect biomarkers non-oral diseases conditions may significant leap toward goal.

Language: Английский

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Severe Acute Bronchial Asthma with Sepsis: Determining the Status of Biomarkers in the Diagnosis of the Disease

Diagnostics, Journal Year: 2023, Volume and Issue: 13(16), P. 2691 - 2691

Published: Aug. 16, 2023

Bronchial asthma is a widely prevalent illness that substantially impacts an individual's health standard worldwide and has significant financial impact on society. Global guidelines for managing do not recommend the routine use of antimicrobial agents because most episodes condition are linked to viral respiratory tract infections (RTI), bacterial infection appears have insignificant impact. However, antibiotics recommended when there high-grade fever, consolidation chest radiograph, purulent sputum contains polymorphs rather than eosinophils. Managing acute bronchial with sepsis, specifically choice whether or initiate treatment, remains difficult since currently no practical clinical radiological markers allow simple distinction between infections. Researchers found serum procalcitonin (PCT) values can efficiently safely minimize antibiotic usage in individuals severe asthma. Again, manifestations RTI similar, as frequently used test values, like C-reactive protein (CRP) white blood cell (WBC) count, making it harder doctors differentiate patients. The role scope each biomarker been precisely defined yet, although they all established aid healthcare professionals their diagnostics treatment strategies.

Language: Английский

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Microfluidics in the diagnosis, treatment, and drug delivery of chronic respiratory disorders: Advancements and potential applications

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 209 - 265

Published: Nov. 1, 2024

Language: Английский

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