Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(4), P. 838 - 860
Published: June 22, 2023
Language: Английский
Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154889 - 154889
Published: May 20, 2023
Language: Английский
Citations
16
Journal of Integrative Neuroscience, Journal Year: 2023, Volume and Issue: 22(3)
Published: May 6, 2023
As a large and heterogeneous group of disorders, neurodegenerative diseases are characterized by the progressive loss structure or function in neurons, finally leading to neuronal death. Neurodegenerative cause serious threat patient’s quality life most common Alzheimer’s disease Parkinson’s disease. Currently, little is known detailed etiology these disorders; as such, there no effective treatments available. Furthermore, lack targeted, effective, resolvable therapy for diseases, represents an expanding research field discovery new therapeutic strategies. Investigations potential pathogenesis will become basis preventing occurrence development finding therapies. Existing theories mechanisms, such genetic environmental factors, abnormal protein accumulation, oxidative stress, intricately associated with each other. However, molecular theory that can entirely explain pathological processes underlying diseases. Due experimental technology support multidisciplinary integration, it has been possible perform more in-depth on targets have many exciting discoveries terms original mechanisms. With this review, we intend review existing literature provide insights into mechanisms
Language: Английский
Citations
14
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Jan. 27, 2023
At present, the preventive effect of ischemic stroke is not ideal, and drugs are limited. Danshen, dried root Salvia miltiorrhiza Bge, a common medicinal herb in Traditional Chinese Medicine, which has been used for treatment cardiovascular diseases many years. Phenolic Acids extracted from danshen, showed multiple biological activities, have developed as an injection stroke. However, its on fully reported. The current study aimed to identify potential active phenolic acids prevention explore mechanism using network pharmacology experimental analyses. targets were obtained public databases. Network predicted that 35 kinds had 201 core with include IL-6, AKT1, VEGFA, etc. signaling pathways involved AGE-RAGE pathway, HIF-1 cAMP pathways, Then, antiplatelet was screened by vitro experiment. Our results good inhibitory ADP-induced platelet aggregation salvianolic acid A effect. We further demonstrated SAA administration reduced neurobehavioral scores, decreased infarct size, protected tight junction proteins autologous thrombus model. These studies only shed light mechanisms components stroke, but also provided theoretical information development new medicines Danshen In addition, our suggest be candidate drug.
Language: Английский
Citations
11
Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e33265 - e33265
Published: June 1, 2024
Electroacupuncture pretreatment is considered as an optimal strategy for inducing cerebral ischaemic tolerance. However, the underlying neuroprotective mechanism of this approach has never been explored from perspective calcium homeostasis. Intracellular overload a key inducer cascade neuronal injury in early stage after ischaemia attack and Na
Language: Английский
Citations
4
Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 4625 - 4646
Published: July 1, 2024
Abstract: Ischemic stroke constitutes a significant global health care challenge, and comprehensive understanding of its recovery mechanisms is imperative for the development innovative therapeutic strategies. Angiogenesis, pivotal element ischemic tissue repair, facilitates restoration blood flow to damaged regions, thereby promoting neuronal regeneration functional recovery. Nevertheless, underlying postischemic angiogenesis remain incompletely elucidated. This review meticulously examines constituents neurovascular unit, ion channels, molecular mediators, signaling pathways implicated in following stroke. Furthermore, it delves into prospective strategies informed by these factors. Our objective provide detailed exhaustive information on intricate governing angiogenesis, thus providing robust scientific foundation advancement novel neurorepair therapies. Keywords: stroke,
Language: Английский
Citations
4
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 261 - 261
Published: Feb. 15, 2025
Long-lasting brain fatigue is a consequence of stroke or traumatic injury associated with emotional, psychological, and physical overload, distress in hypertension, atherosclerosis, viral infection, aging-related chronic low-grade inflammatory disorders. The pathogenesis linked to disrupted neurotransmission, the glutamate-glutamine cycle imbalance, glucose metabolism, ATP energy supply, which are multiple molecular targets signaling pathways neuroendocrine-immune blood circulation systems. Regeneration damaged tissue long-lasting multistage process, including spontaneously regulating hypothalamus-pituitary (HPA) axis-controlled anabolic-catabolic homeostasis recover harmonized sympathoadrenal system (SAS)-mediated function, deregulated gene expression rehabilitation. driving mechanism spontaneous recovery regeneration cross-talk mediators neuronal, microglia, immunocompetent, endothelial cells collectively involved neurogenesis angiogenesis, plant adaptogens can target. Adaptogens small molecules origin that increase adaptability organisms stress by interaction HPA axis SAS (neuroendocrine-immune cardiovascular complex), targeting adaptive GPCR pathways. Two major groups comprise (i) phenolic phenethyl phenylpropanoid derivatives (ii) tetracyclic pentacyclic glycosides, whose chemical structure be distinguished as related correspondingly monoamine neurotransmitters (epinephrine, norepinephrine, dopamine) steroid hormones (cortisol, testosterone, estradiol). In this narrative review, we discuss multitarget integrated pharmacological activity botanical ischemic stroke, fatigue; time-dependent dual response physiological regulatory systems support overload; (iii) dose-dependent reversal (hormetic) effect adaptogens. This review shows adaptogenic concept cannot reduced rectified various effects on selected specific modes action without estimating their interactions within networks complex that, turn, regulates other (cardiovascular, gastrointestinal, reproductive systems) due numerous intra- extracellular communications feedback regulations. These result polyvalent pleiotropic adaptogens, essential for characterizing distinct types botanicals. They trigger defense leads extension limits resilience inducing mental For first time, justifies potential particularly hybrid preparation (BHP) Arctic Root Ashwagandha, providing rationale use individuals experiencing fatigue. provided insight into future research network pharmacology preventing rehabilitating following trauma, infections.
Language: Английский
Citations
0
Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107473 - 107473
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2175 - 2175
Published: Feb. 28, 2025
Among all stroke types, ischemic (IS) occurs most frequently, resulting in neuronal death and tissue injury within both the central infarct region surrounding areas. This study explored neuroprotective mechanisms of scutellarin, a flavonoid compound, through an integrated strategy that merged silico analyses (including network pharmacology molecular docking simulations) with vitro vivo experimental verification. We identified 1887 IS-related targets 129 scutellarin targets, 23 overlapping targets. PPI analysis revealed five core demonstrated strong binding affinities between these Bioinformatic analyses, including GO functional annotation KEGG pathway mapping, indicated PI3K/AKT cascade represents primary signaling mechanism. An system was developed using PC12 cells under oxygen-glucose deprivation conditions to investigate how regulates cell via pathway. Western blot quantification treatment enhanced expression p-PI3K, p-AKT, Bcl-2 proteins, while simultaneously reducing levels apoptotic markers Bax cleaved caspase-3. Furthermore, pharmacological intervention selective PI3K inhibitor LY294002 attenuated alterations, diminished Bcl-2, accompanied by elevated In rat model middle cerebral artery occlusion, administration comparable effects, maintaining survival modulating protein activation. Collectively, this demonstrates therapeutic potential ischemia modulation, suggesting its possible application treating disorders.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 27, 2025
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory response elicited by cerebral tissue damage during an event. However, in-depth mechanistic understanding of their connection remains limited. This study aims to comprehensively analyze gene expression patterns pyroptosis-related differentially expressed genes (PRDEGs) employing integrated IS datasets machine learning techniques. primary objective was develop classification models identify crucial PRDEGs integral process. Leveraging three distinct algorithms (LASSO, Random Forest, Support Vector Machine), were developed differentiate Control patient samples. Through this approach, a core set 10 consistently emerged as significant across all models. Subsequent analysis these yielded insights into functional relevance potential therapeutic approaches. In conclusion, investigation underscores pivotal role pathways in identifies pertinent targets for development drug repurposing.
Language: Английский
Citations
0
Jundishapur Journal of Natural Pharmaceutical Products, Journal Year: 2025, Volume and Issue: 20(1)
Published: Feb. 26, 2025
Background: Cerebral ischemia activates harmful biochemical pathways that result in blood-brain barrier (BBB) breakdown and neuronal damage. Natural compounds such as chrysin gallic acid (GA), known for their antioxidant anti-inflammatory properties, may protect the BBB reduce injury. Objectives: This study aimed to examine effects of combining GA on hippocampal damage, cognitive function, integrity, claudin-5 expression a mouse model cerebral ischemia. Methods: was induced through bilateral common carotid artery occlusion (BCCAO) 30 minutes, followed by 48 hours reperfusion. Chrysin (30 mg/kg, intraperitoneally), (50 combination were administered at start reperfusion subsequently minutes 1 hour. Hippocampal spatial memory, Evans blue (EB) leakage, evaluated after Results: Administration chrysin, GA, significantly enhanced survival CA1, CA3, dentate gyrus (DG) regions (P < 0.001). The diminished neurological deficit scores (1.5 ± 0.22 vs. control 3.5 0.56, P 0.05) escape latency time (12.8 4.5 40 4.82 seconds, 0.01). Likewise, these interventions reduced EB leakage (3.46 0.62 11.28 0.98 μg/g brain tissue) upregulated (38% 1.29 10.75% 1.65, Conclusions: demonstrated combined treatment synergistically promoted neuron survival, improved maintained integrity upregulating expression. We suggest this therapeutic approach offer potential benefits stroke patients, though further experimental clinical investigation is required confirm its efficacy.
Language: Английский
Citations
0