Separations,
Journal Year:
2023,
Volume and Issue:
10(6), P. 364 - 364
Published: June 18, 2023
Quantity
and
measure
value
transfer
is
widely
used
to
examine
the
correlation
between
quality
of
Chinese
herbs,
herbal
intermediates,
patent
medicines.
This
study
performed
a
quantity
analysis
assess
total
solids
yield,
phenolic
component
purity
in
Salvia
miltiorrhiza
purified
extract
(SMPE)
preparation
process.
The
amount
extracted
was
45–250
mg/g
following
processes
reflux
extraction,
vacuum
concentration,
lime–sulfuric
acid
refining,
first
ethanol
precipitation,
second
acidification,
alkalization,
thermal
hydrolysis,
acidification.
Regarding
yield
purity,
Danshensu
ranked
among
all
components.
Additionally,
quantitative
index
defined
as
variation
(TV)
proposed
describe
consistency
SMPE
batch-to-batch
came
from
variable
herb
process,
latter
contributed
more.
contribution
individual
(TVP)
an
impact
on
consistency.
According
TVP
value,
refining
precipitation
acidification
process
were
deemed
crucial.
When
similarity
algorithms
for
composition
intermediates
examined,
Euclidean
distance
outperformed
Pearson
coefficient,
Spearman
cosine
pinch
angles.
Based
average
(ΔDj¯)
during
hydrolysis
determined
be
critical.
clarified
primary
causes
fluctuation,
identified
critical
processes,
examined
pharmaceutical
traditional
medicine
(TCM)
standpoint
transfer.
method
can
reference
other
TCM
processes.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(4), P. 538 - 538
Published: April 7, 2025
Herbs,
used
as
food
and
a
source
of
medicine
for
centuries,
have
been
extensively
studied
over
time
their
chemical
pharmacological
properties,
with
two
main
aims
[...]
Polimery,
Journal Year:
2024,
Volume and Issue:
69(1), P. 33 - 43
Published: Feb. 13, 2024
Materials
based
on
polydimethylsiloxane
have
been
developed
with
antibacterial
activity
and
mechanical
properties
required
for
wound
treatment.
Sage
herb
(raw,
modified,
polyphenol
extract)
was
used
as
a
filler
in
an
amount
of
5
10%
by
weight.
Physicochemical,
mechanical,
biological
were
examined.
The
results
indicate
beneficial
effect
sage
modification
the
tested
properties.
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
38(1), P. 411 - 453
Published: Dec. 5, 2023
Abstract
Ischemic
stroke
(IS)
remains
one
of
the
leading
causes
death
and
disability
in
humans.
Unfortunately,
none
treatments
effectively
provide
functional
benefits
to
patients
with
IS,
although
many
do
so
by
targeting
different
aspects
ischemic
cascade
response.
The
advantages
traditional
Chinese
medicine
(TCM)
preventing
treating
IS
are
obvious
terms
early
treatment
global
coordination.
efficacy
TCM
its
bioactive
constituents
has
been
scientifically
proven
over
past
decades.
Based
on
clinical
trials,
this
article
provides
a
review
commonly
used
patent
medicines
herbal
decoctions
indicated
for
IS.
In
addition,
paper
also
reviews
mechanisms
recent
years,
both
domestically
internationally.
A
comprehensive
preclinical
studies
will
hopefully
new
ideas
address
threat
The Heart Surgery Forum,
Journal Year:
2024,
Volume and Issue:
27(3), P. E252 - E263
Published: March 17, 2024
Objective:
To
investigate
the
effect
and
mechanism
of
Danshen
Zhizi
Compatibility
(DZ)
on
alleviating
heart
injury
cardiac
ferroptosis
in
rats
with
myocardial
infarction.
Methods:
A
rat
model
infarction
was
established
by
ligation
left
anterior
descending
artery.
The
were
equally
randomly
divided
into
5
groups.
sham
group
underwent
open-chest
surgery
without
arterial
ligation,
while
other
4
groups
surgery,
including
3
treated
low
dose
(4
g/kg/d),
high
(8
g/kg/d)
DZ
supplemented
H-89
(0.5
mg/kg/d)
respectively.
received
same
volume
saline.
14
days
after
serum
tissues
harvested
to
detect
cyclic
adenosine
monophosphate
(cAMP)
protein
kinase
(PKA)
activity,
level
ferroptosis.
Results:
G-protein
coupled
receptors
(GPCRs)
have
a
binding
affinity
main
components
DZ,
which
indicated
that
probably
contributed
ameliorating
activating
downstream
(cAMP)/protein
signaling.
Treatment
significantly
increased
cAMP
concentration
serum,
PKA
activity
tissue
upregulated
perilipin
(PLIN)5
expression.
attenuated
injury,
whereas
reversed
protective
effects
DZ.
In
addition,
administration
inhibited
as
evidenced
reduced
malondialdehyde
(MDA),
4-hydroxynonenal
(4-HNE)
levels.
glutathione
(GSH)
levels
Glutathione
peroxidase
(GPX)4
expression
tissue,
abrogated
regulatory
Conclusion:
Our
results
demonstrated
alleviated
through
cAMP-PKA
signalling
pathway.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 10, 2024
Arecanut
seed
is
an
important
traditional
medicine
in
Southeast
Asia.
It
has
been
presented
a
clinical
formula
to
treat
osteoporosis
(OP)
China.
abundant
phenols.
However,
most
of
current
studies
mainly
focused
on
estrogen-deficient
model
arecanut
phenols
(ASP),
there
still
lack
roundly
research
about
molecular
mechanism
ASP
therapy
OP
and
its
influence
drug-induced
bone
loss.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 14, 2023
Introduction:
Pharbitidis
Semen
(PS)
has
been
widely
used
in
traditional
Chinese
medicine
to
treat
several
diseases
such
as
nephritis.
PS
is
usually
stir-fried
enhance
its
therapeutic
efficacy
before
use
clinical
practice.
However,
the
changes
phenolic
acids
during
stir-frying
and
mechanisms
of
their
effects
on
nephritis
are
still
unclear.
Methods:
Here,
we
studied
processing-induced
chemical
elucidated
mechanism
treatment
We
determined
levels
7
raw
(RPS)
(SPS)
using
high-performance
liquid
chromatography,
analyzed
dynamic
compositional
stir-frying,
network
analysis
molecular
docking
predict
verify
compound
targets
pathways
corresponding
Results:
The
suggestive
a
transesterification
reaction.
Pathway
revealed
that
were
mainly
enriched
AGE-RAGE,
hypoxia-inducible
factor-1,
interleukin-17,
tumor
necrosis
factor
signaling
among
others.
Molecular
results
showed
had
good
binding
ability
with
key
nephritic
targets.
Discussion:
potential
pharmaceutical
basis,
targets,
treating
explored.
Our
findings
provide
scientific
basis
for
