Jin-Zhen oral liquid for pediatric coronavirus disease (COVID-19): A randomly controlled, open-label, and non-inferiority trial at multiple clinical centers DOI Creative Commons
Qian Dong,

Hongmei Qiao,

Huiyi Jiang

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 27, 2023

Background: As the coronavirus disease 2019 (COVID-19) pandemic progressed, especially with emergence of Omicron variant, proportion infected children and adolescents increased significantly. Some treatment such as Chinese herbal medicine has been administered for COVID-19 a therapeutic option. Jin-Zhen Oral Liquid is widely used pediatric acute bronchitis, while efficacy safety in are unclear. Methods: We conducted randomized controlled, open-label, multicenter, non-inferiority clinical study involving hospitalized mild to moderate COVID-19. Children eligible enrollment were randomly assigned 1:1 ratio (the group) Jinhua Qinggan Granules positive control received respective agent 14 days, followed by 14-day follow-up after discontinuation treatment. The primary endpoint was time first negative viral testing. secondary endpoints rate major symptoms disappearance, duration hospitalization, changed from asymptomatic or severe/critical illness. In addition, end points any adverse events observed. Results: A total 240 child patients into (117 patients) (123 groups. There no significant difference baselines terms characteristics initial between two After administration, testing group (median 6.0 95% CI 5.0-6.0) significantly shorter compared 7.0 7.0-8.0). disappearance comparable control. symptom pharyngalgia hospitalization shortened Jin-zhen group. No participants either experienced post-treatment exacerbation severe critical observed (0.0%) 1 patient occurred granules (0.8%). serious during period both Conclusion: safe effective medium children. It non-inferior shortening testing, duration. results suggest that can be recommended drug patients.

Language: Английский

Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives DOI Creative Commons
Cheng Zhang, Guoming Chen,

Guoyi Tang

et al.

Acta Materia Medica, Journal Year: 2023, Volume and Issue: 2(1)

Published: Jan. 1, 2023

For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism action as desirable candidates for potential drugs. However, this conventional strategy faced challenges including low success rate high costs. Herein, we critically review state-of-the-art based on multi-component Chinese medicine formulas. We policies application status new drugs medicines in US, China, European Union. Moreover, illustrate several excellent cases ongoing applications. Biomedical technologies that may facilitate formulas are discussed, network pharmacology, integrative omics, CRISPR gene editing, chemometrics. Finally, discuss problems solutions pre-clinical clinical research hope will promote discussion roles treatment human diseases.

Language: Английский

Citations

32
Role of dietary supplements in the continuous battle against COVID‐19 DOI
Rahela Zaman, Vignesh Ravichandran, Chung Keat Tan

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(2), P. 1071 - 1088

Published: Jan. 2, 2024

Abstract A sudden outbreak of the COVID‐19 pandemic was a big blow to world community on every level. Created by novel coronavirus, SARS‐CoV‐2, which previously unknown human immune system. The expert opinion almost immediately united fact that most effective way fighting would be building immunity artificially via mass immunization program. However, it took about year for approval first vaccine against COVID‐19. In meantime, part general population started adapting nutritious diet plans and dietary supplements boost natural as potential prophylactic strategy SARS‐CoV‐2 infection. Whether they originate from mainstream medicine, such synthetic supplements, or traditional herbal remedies in form single poly‐herbs, these may comprise various components exhibit immunomodulatory, anti‐inflammatory, antioxidant, antimicrobial characteristics. There is substantial body predictions opinions suggesting enhancing one's with containing additional nutrients bioactive compounds like vitamins, minerals, amino acids, fatty phytochemicals, probiotics can enhance system's ability develop resistance COVID‐19, although none them have any conclusive evidence nor officially recommended World Health Organization (WHO). current review critically acclaims gap between public perception‐based preference real evidence‐based study weigh actual benefit relation prevention management.

Language: Английский

Citations

7
Recent advances towards natural plants as potential inhibitors of SARS-Cov-2 targets DOI Creative Commons

Zhouman He,

Jia Yuan, Yuanwen Zhang

et al.

Pharmaceutical Biology, Journal Year: 2023, Volume and Issue: 61(1), P. 1186 - 1210

Published: Aug. 22, 2023

Context Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still ongoing and currently the most striking epidemic disease. With rapid global spread of SARS-CoV-2 variants, new antivirals are urgently needed to avert a more serious crisis. Inhibitors from traditional medicines or natural plants have shown promising results fight COVID-19 with different mechanisms action.Objectives To provide comprehensive approaches medical community in against this reviewing potential plant-derived anti-SARS-CoV-2 inhibitors.Methods Structural databases such as TCMSP (http://lsp.nwu.edu.cn/tcmsp.php), TCM Database @ Taiwan (http://tcm.cmu.edu.tw/), BATMAN-TCM (http://bionet.ncpsb.org/batman-tcm/) TCMID (http://www.megabionet.org/tcmid/), well PubMed, Sci Finder, Research Gate, Science Direct, CNKI, Web Google Scholar were searched for relevant articles on TCMs products SARS-CoV-2.Results Seven Chinese formulas unique advantages regulating immune system treating COVID-19. The compounds inhibitors identified based 5 key proteins, namely, angiotensin-converting enzyme (ACE2), 3 C-like protease (3CLpro), papain-like (PLpro), spike (S) protein, nucleocapsid (N) protein.Conclusions A variety products, flavonoids, terpenoids, phenols, alkaloids, identified, which could be used SASR-Cov-2 inhibitors. These shed light efficient discovery products.

Language: Английский

Citations

11
The efficacy of different traditional Chinese medicine treatment for Corona Virus Disease 2019: Systematic Review and Meta-analysis DOI Creative Commons

S U Youzhu,

Rui Su, Shuo Wang

et al.

Journal of Herbal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101001 - 101001

Published: Feb. 1, 2025

Language: Английский

Citations

0
Effect of Traditional Chinese Medicine on COVID-19 Treatment: A Meta-Analysis of Randomized Clinical Trials DOI Creative Commons
Marharyta Sobczak, Rafał Pawliczak

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 357 - 357

Published: March 2, 2025

Background/Objectives: Traditional Chinese medicine (TCM) has a long history and is known for its anti-inflammatory, antiviral, immunoregulatory qualities. It been extensively studied during the COVID-19 pandemic. Therefore, to evaluate relationship between TCM treatment of COVID-19, we conducted meta-analysis. Methods: Our meta-analysis included 22 randomized clinical trials, which investigated analyzed endpoints: time recovery from fever, severity dyspnea or breathlessness according on different scales, coughing, including dry wet fatigue, changes in respiratory rate, length hospitalization, hospital discharging number intensive care unit (ICU) admissions, cases requiring any supplemental oxygenation, deaths among patients, conversion rate SARS-CoV-2 tests particular day, viral assay conversion. The relative risk (RR) with 95% confidence intervals (CIs) mean difference standardized CIs were calculated compare effect. A random effects model was used calculate effect sizes. Results: We indicated positive symptoms. influences hospitalization duration, ICU admission, mortality, patients. Moreover, positively affects test rates days (RR = 1.21; CI [1.10; 1.32]; p < 0.0001; I2 84%). Conclusions: may potentially support standard COVID-19. Nevertheless, necessity further trials greater participants wider range countries remains apparent.

Language: Английский

Citations

0
The methodological reporting quality in strictly randomized controlled trials for COVID-19 and precise reporting of Chinese herbal medicine formula intervention DOI Creative Commons
Min‐Li Chen,

Shi-Yan Qian,

Jiang-Li Yang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

Chinese herbal medicine (CHM) formulas played an important role during the pandemic of coronavirus disease 2019 (COVID-19). Many randomized controlled trials (RCTs) on CHM for COVID-19 were quickly published. Concerns have been raised about their quality. In addition, inadequate detailed information formula intervention may arouse suspicion effectiveness. We aim to assess most recent evidence methodological reporting quality these RCTs with strict randomization, and precise intervention. searched from nine databases. The CONSORT 2010, CONSORT-CHM Formulas 2017, risk bias guidelines used included RCTs. checklist sub-questions based 2017 was evaluate A comparison made between that enrolled participants after first wave (defined here as December March 2020). average score 66 studies evaluated three guidelines, is 16.4, 15.2, 17.2, respectively. rate sample size calculation, allocation concealment, blinding less than 30%. can help report more precisely. Most assessed "unclear bias" due insufficient information. published in English recruited subjects a higher participant (P < 0.05). strictly inadequate-the need improve especially. worse pandemic.

Language: Английский

Citations

0
Recent advances in Chinese patent medicines entering the international market DOI Open Access
Bo Zhang,

Wenjian Pei,

Pingping Cai

et al.

Drug Discoveries & Therapeutics, Journal Year: 2022, Volume and Issue: 16(6), P. 258 - 272

Published: Dec. 20, 2022

As an indispensable part of Traditional Chinese medicine (TCM), patent medicines have played important role in preventing and treating diseases China. Since they are easy to use, store, cost-effective, been generally accepted widely used clinical practice as a vital medical resource. In recent years, TCM has developed it around the world, many companies gained international market access successfully registered several over-the-counter (OTC) or prescription drugs regions countries that primarily use Western such EU, Russia, Canada, Singapore, Vietnam. Moreover, obtained US Food Drug Administration (FDA) approval conducting phase II III trials US. The current work focused on submitted for registration abroad. Summarized here advances efficacy molecular mechanisms these treat respiratory infectious (Lianhua Qingwen capsules, Jinhua Qinggan granules, Shufeng Jiedu Capsules), cardiovascular cerebrovascular (Compound Danshen Dripping Pills, Huatuo Zaizao pills, Tongxinluo cancers (a Kanglaite injection Shenqi Fuzheng Injection), gynecological (Guizhi Fuling Capsules). hope is this review will contribute better understanding by people world.

Language: Английский

Citations

14
Effect of salidroside on neuroprotection and psychiatric sequelae during the COVID-19 pandemic: A review DOI Creative Commons
Ting Zhu, Hui Liu,

Shiman Gao

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115999 - 115999

Published: Dec. 12, 2023

The coronavirus disease 2019 (COVID-19) pandemic has affected the mental health of individuals worldwide, and risk psychiatric sequelae consequent disorders increased among general population, care workers patients with COVID-19. Achieving effective widespread prevention pandemic-related to protect global population is a serious challenge. Salidroside, as natural agent, substantial pharmacological activity effects, exerts obvious neuroprotective may be in preventing treating resulting from stress stemming COVID-19 pandemic. Herein, we systematically summarise, analyse discuss therapeutic effects salidroside treatment well its roles progression disorders, fully clarify potential widely applicable agent for caused by stress; mechanisms underlying protective are involved regulation oxidative stress, neuroinflammation, neural regeneration cell apoptosis brain, network homeostasis neurotransmission, HPA axis cholinergic system, improvement synaptic plasticity. Notably, this review innovatively proposes that stress-induced issues during provides scientific evidence theoretical basis use products combat current crisis.

Language: Английский

Citations

8
Effect of Lianhua Qingwen capsules on the positive rate of COVID-19 close contacts: A retrospective analysis of a large-scale population-based cohort study DOI Creative Commons

Yunfeng Qiao,

Xiaolong Xu, Fangfang Zhou

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 112, P. 154690 - 154690

Published: Feb. 3, 2023

Coronavirus disease 2019 (COVID-19) is still spreading worldwide. COVID-19 close contact a key point of this epidemic. However, no medication now available for contact. This study aims to evaluate the beneficial effect and safety Lianhua Qingwen capsule (LHQW) on contacts via large, retrospective cohort study.A total 25,002 from 199 quarantine sites in Changchun, Jilin, who underwent medical observation, were included. The information about these collected further epidemiological research. Moreover, subjects divided into an exposure group (LHQW group, oral, 4 capsules/time, t.i.d.; 18,579 subjects) non-exposure (control group; 6,423 subjects). Inverse probability treatment weighting (IPTW) with propensity score was employed positive rate SARS-CoV-2 nucleic acid test nasal throat swabs confirmed by polymerase chain reaction (PCR).A 22,975 included analysis, 17,286 cases LHQW 5,689 control group. testing 5.12%, that 9.70% before adjustment IPTW score; difference between two groups -4.58% (95% CI -5.44- -3.77%, p < 0.001). After adjusting IPTW, 5.10% 9.80%, respectively; -4.70% -5.18- -4.23, conclusions after consistent. No drug-related adverse reactions observed during period.LHQW has are under observation at can be used as optional drug those contacts.

Language: Английский

Citations

6
New perspective on the immunomodulatory activity of ginsenosides: Focus on effective therapies for post-COVID-19 DOI Open Access
Yixin Wang, Qin Han, Shuxia Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115154 - 115154

Published: July 14, 2023

More than 700 million confirmed cases of Coronavirus Disease-2019 (COVID-19) have been reported globally, and 10–60% patients are expected to exhibit "post-COVID-19 symptoms," which will continue affect human life health. In the absence safer, more specific drugs, current multiple immunotherapies failed achieve satisfactory efficacy. Ginseng, a traditional Chinese medicine, is often used as an immunomodulator has in COVID-19 treatment tonic increase blood oxygen saturation. Ginsenosides main active components ginseng. this review, we summarize ways ginsenosides post-COVID-19 symptoms, including inhibition lipopolysaccharide, tumor necrosis factor signaling, modulation chemokine receptors inflammasome activation, induction macrophage polarization, effects on Toll-like receptors, nuclear kappa-B, mitogen-activated protein kinase pathway, lymphocytes, intestinal flora, epigenetic regulation. virus-mediated tissue damage, local or systemic inflammation, immune modulation, other links, thus alleviating respiratory pulmonary reducing cardiac burden, protecting nervous system, providing new ideas for rehabilitation with symptoms. Furthermore, analyzed its role strengthening body resistance eliminate pathogenic factors from perspective ginseng-epidemic disease highlighted challenges clinical applications. However, benefit modulating organismal imbalance needs be further evaluated better validate pharmacological mechanisms associated their efficacy determine individualized therapy.

Language: Английский

Citations

6