Newborn auditory brainstem response and sudden infant death syndrome DOI Creative Commons
Sarah E. Maylott, Guangyu Zeng, Tiffany S. Leung

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(6)

Published: June 1, 2024

Abstract Sudden infant death syndrome (SIDS)—the sudden and unexplained of a seemingly healthy infant, <1 year old—may be associated with abnormalities in the brain regions that underlie breathing arousal during sleep. While post‐mortem studies suggest SIDS infants' brainstems, there are no these brainstem function before death. One way to assess is auditory response (ABR), routine hearing‐screening method noninvasively measures brainstem's sound. We hypothesize anomalies newborns' ABR may predict SIDS. Indeed, previous identified characteristics small samples near‐miss infants hospitalized for apnea syndrome. However, need examine ABRs who died Therefore, current study, we propose integrating two secondary datasets ( N = 156,972), including those later n ~42; .27 out every 1000 infants), using existing archived records neonatal results from sample newborns born Florida. die more likely than non‐SIDS have abnormal as newborns. Understanding association between facilitate accurate identification an infant's risk at birth, enabling increased monitoring, which interventions improve survivorship.

Language: Английский

The vicious spiral in Sudden Infant Death Syndrome DOI Creative Commons
Siri H. Opdal, Arne Stray‐Pedersen, Johanna Marie Lundesgaard Eidahl

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 11, 2025

Sudden Infant Death Syndrome (SIDS) is the sudden and unexpected death of an otherwise healthy infant less than 1 year age where cause remains unexplained after a thorough post-mortem investigation evaluation circumstances. Epidemiological, clinical, biochemical, immunological pathological evidence indicates that three factors must coincide for SIDS to occur: vulnerable developmental stage immune system central nervous in infant, predisposing factors, external trigger events. This model referred as fatal triangle or triple risk hypothesis. The concept vicious spiral SIDS, starting with ending death, proposed understand mechanism. initiated by mucosal infection activation upper respiratory digestive tracts, increased production cytokines, overstimulation immature rapidly developing system. A second prone sleeping position, which may lead rebreathing hypercapnia, addition intensify stimulation. In susceptible infants, this induces aberrant cytokine affects sleep regulation, hyperthermia, disrupts arousal mechanisms. turn, initiates downregulation respiration hypoxemia, worsened nicotine. Inefficient autoresuscitation results severe hypoxia accumulation hypoxic markers which, if not prevented normally functioning serotonergic network, contribute self-amplifying eventually leads coma death. purpose review summarize research underpins spiral.

Language: Английский

Citations

0
The Genetics of Sudden and Unexpected Death DOI
Monica H. Wojcik, Richard D. Goldstein

Published: Jan. 1, 2025

Language: Английский

Citations

0
Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis DOI Creative Commons
Kevin J. Cummings, James C. Leiter,

Felicia Trachtenberg

et al.

Journal of Neuropathology & Experimental Neurology, Journal Year: 2024, Volume and Issue: 83(3), P. 144 - 160

Published: Feb. 7, 2024

Abstract The failure of chemoreflexes, arousal, and/or autoresuscitation to asphyxia may underlie some sudden infant death syndrome (SIDS) cases. In Part I, we showed that SIDS infants had altered 5-hydroxytryptamine (5-HT)2A/C receptor binding in medullary nuclei supporting and autoresuscitation. Here, using the same dataset, tested hypotheses prevalence low 5-HT1A 5-HT2A/C (defined as levels below 95% confidence interval controls—a new approach), percentages affected are greater versus controls, distribution varied with age death. percentage were twice controls. was older infants. &gt;80% infants, characterized hypoglossal nucleus, vagal dorsal nucleus solitary tract, olivocerebellar subnetwork (important for blood pressure regulation). Together, our findings from animal models serotonergic dysfunction suggest cases represent a serotonopathy. We present hypotheses, yet be tested, about how defects within subnetworks lead SIDS.

Language: Английский

Citations

3
Divergent Causes and Convergent Mechanisms of SUDEP DOI Creative Commons
George B. Richerson

Annals of Neurology, Journal Year: 2023, Volume and Issue: 94(5), P. 809 - 811

Published: Sept. 16, 2023

Language: Английский

Citations

7
Newborn auditory brainstem response and sudden infant death syndrome DOI Creative Commons
Sarah E. Maylott, Guangyu Zeng, Tiffany S. Leung

et al.

Journal of Neuroscience Research, Journal Year: 2024, Volume and Issue: 102(6)

Published: June 1, 2024

Abstract Sudden infant death syndrome (SIDS)—the sudden and unexplained of a seemingly healthy infant, <1 year old—may be associated with abnormalities in the brain regions that underlie breathing arousal during sleep. While post‐mortem studies suggest SIDS infants' brainstems, there are no these brainstem function before death. One way to assess is auditory response (ABR), routine hearing‐screening method noninvasively measures brainstem's sound. We hypothesize anomalies newborns' ABR may predict SIDS. Indeed, previous identified characteristics small samples near‐miss infants hospitalized for apnea syndrome. However, need examine ABRs who died Therefore, current study, we propose integrating two secondary datasets ( N = 156,972), including those later n ~42; .27 out every 1000 infants), using existing archived records neonatal results from sample newborns born Florida. die more likely than non‐SIDS have abnormal as newborns. Understanding association between facilitate accurate identification an infant's risk at birth, enabling increased monitoring, which interventions improve survivorship.

Language: Английский

Citations

0