Endothelial Unfolded Protein Response‐Mediated Cytoskeletal Effects DOI
Joy T. Folahan,

Saikat Fakir,

Nektarios Barabutis

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)

Published: Oct. 25, 2024

ABSTRACT The endothelial semipermeable monolayers ensure tissue homeostasis, are subjected to a plethora of stimuli, and their function depends on cytoskeletal integrity remodeling. permeability those membranes can fluctuate maintain organ homeostasis. In cases severe injury, inflammation or disease, barrier hyperpermeability cause irreparable damage endothelium‐dependent issues, eventually death. Elucidation the signaling regulating structure promotes development targeted pharmacotherapies towards disorders related impaired endothelium (e.g., acute respiratory distress syndrome, sepsis). Recent reports investigate role unfolded protein response in function. Herein we review components, function; interrelations health disorder. Moreover, emphasize modulators, since they ameliorate illness leak.

Language: Английский

NEK kinases in cell cycle regulation, DNA damage response, and cancer progression DOI
Joy T. Folahan, Nektarios Barabutis

Tissue and Cell, Journal Year: 2025, Volume and Issue: 94, P. 102811 - 102811

Published: March 1, 2025

Language: Английский

Citations

0
Endothelial Unfolded Protein Response‐Mediated Cytoskeletal Effects DOI
Joy T. Folahan,

Saikat Fakir,

Nektarios Barabutis

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)

Published: Oct. 25, 2024

ABSTRACT The endothelial semipermeable monolayers ensure tissue homeostasis, are subjected to a plethora of stimuli, and their function depends on cytoskeletal integrity remodeling. permeability those membranes can fluctuate maintain organ homeostasis. In cases severe injury, inflammation or disease, barrier hyperpermeability cause irreparable damage endothelium‐dependent issues, eventually death. Elucidation the signaling regulating structure promotes development targeted pharmacotherapies towards disorders related impaired endothelium (e.g., acute respiratory distress syndrome, sepsis). Recent reports investigate role unfolded protein response in function. Herein we review components, function; interrelations health disorder. Moreover, emphasize modulators, since they ameliorate illness leak.

Language: Английский

Citations

2