Exploring the Role of Inflammatory Cytokines in Cervical cancer Pathogenesis: Evidence from Mendelian Randomization Analysis DOI Creative Commons
Yuqiang Zhang,

D.Y. Luo,

Xinguang Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background: Cervical cancer (CC) is a prevalent malignancy worldwide, which seriously threatens women's quality of life and health. Although CC etiology remains uncertain, mounting evidence suggests that inflammatory cytokines (CKs) contribute to pathogenesis. Nonetheless, more research required determine if there causal connection between them. Therefore, our study performed Mendelian randomized (MR) investigate the link CKs CC. Methods: The CK data are derived from two European population databases: one containing 41 other 91 CKs. came UK Biobank (n ≤ 408961), including 1659 cases 381902 controls ancestry. Our employed inverse variance weighted, MR-Egger, weighted median, mode analyze relation Additionally, multiple sensitivity analyses, MRE intercept test, MR-PRESSO Leave One Out, were deployed further validate robustness results. Eventually, reverse MR analysis was carried out. RESULTS: results showed increase Monokine triggered by gamma interferon )INF-γ( level negatively correlated with (odds ratio (OR) = 0.84, 95% confidence interval (95% CI): 0.72–0.99, P 0.044). Elevated cystatin D (CysD), Interleukin-8 (IL-8), Leukemia Inhibitory Factor (LIF), Monocyte chemoattractant protein 2 (MCP-2) levels positively occurrence (OR 1.18, CI:1.02–1.36, 0.025; OR 1.41, CI:1.02–1.95, 0.035; 1.39, CI:1.00–1.94, 0.044; 1.76, CI:1.25–2.47, 9×10–4), aligned analyses Reverse Results had no effect on 132 Conclusion: Herein, demonstrated potential INF-γ, CysD, IL-8, LIF, MCP-2 risk. role in development needs investigation.

Language: Английский

Inflammatory cytokines and oral lichen planus: a Mendelian randomization study DOI Creative Commons
Xin Chen, Simin Zhang, Xiao Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 7, 2024

Background Inflammatory cytokines have long been considered closely related to the development of oral lichen planus (OLP), and we further explored causal relationship between two by Mendelian randomization (MR) method. Methods We performed bidirectional MR analyses large genome-wide association studies (GWAS). The data included a large-scale OLP dataset, as well datasets 41 inflammatory cytokines. All were obtained from University Bristol database, which includes cytokines, GWAS Catalog 91 Finngen 6411 cases 405770 healthy controls. used inverse variance weighted (IVW) method, MR-Egger median simple mode method analyze OLP, also combined with sensitivity analysis verify robustness results. meta-analysis positive or potentially results for same genes confirm reliability final Results primarily IVW corrected using Benjamin Hochberg (BH) When p<0.00038 (0.05/132), are significantly causal; when 0.00038<p<0.05, causal. found total 7 significant potential associations (University database: 2, 5). In reverse analysis, that 30 associated 5, 25). After meta-analysis, finally determined there was 3 in forward most FGF21 (p=0.02954, odds ratio (OR): 1.113, 95% confidence interval (95%CI): 1.011-1.226). 14 causally PLAU (p=0.00002, OR: 0.951, 95%CI: 0.930-0.973). Conclusion There is some may play an important role pathogenesis require attention.

Language: Английский

Citations

5
Exploring the Association Between Human Blood Metabolites and Autism Spectrum Disorder Risk: A Bidirectional Mendelian Randomization Study DOI Creative Commons
Wenhua Li, Suya Ma, Yulong Tian

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(3)

Published: March 1, 2025

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with poorly understood etiology. Recent studies have suggested that metabolic dysregulation might be linked to the development of ASD; however, causal relationships remain unclear. This study aimed investigate association between these factors using two-sample Mendelian randomization (TSMR). We conducted TSMR analysis assess relationship blood metabolites and ASD summarized GWAS data. The metabolite dataset from Canadian Longitudinal Study Aging included 1091 309 ratios 7824 European individuals. data Psychiatric Genomics Consortium comprised 18,381 cases 27,969 controls. Blood were set as exposures outcome. primarily used inverse-variance weighted method, supplemented by MR-Egger, median, simple mode, mode methods. also sensitivity analyses confirm robustness. Replication, confounding, reserve performed verify causation. Additionally, pathway network pharmacology explore potential mechanisms. identified 55 known including 13 10 unknown associated ASD. our pathways, among which tryptophan metabolism was most notable (p = 0.0388). Gene Ontology functional Kyoto Encyclopedia Genes Genomes highlighted crucial such cellular glucuronidation, glucuronosyltransferase activity, bile secretion, significance apical part cell. Our findings indicate dodecenedioate, methionine sulfone, cysteine alanine ratio proline glutamate an impact on These results enhance understanding pathways involved in could lead new avenues for intervention prevention. Further research needed mechanisms underlying associations different populations.

Language: Английский

Citations

0
Association between Frailty and Asthma DOI Creative Commons

Jong Myung Park,

Su-Jin Lee,

Jae Ho Chung

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1479 - 1479

Published: Sept. 10, 2024

Background and Objectives: This study investigated whether there is an association between elderly frailty asthma. Material Methods: We examined 9745 participants who did not have asthma 275 patients had diagnosed by a doctor from the 2020 Survey of Living Conditions Welfare Needs Korean Older Persons Survey. Study Selections: The version fatigue, resistance, ambulation, illnesses, loss weight (K-FRAIL) scale was used to determine their level frailty. relationship geriatric using multiple logistic regression analysis, which adjusted for number confounding variables (socioeconomic, health behavior, psychological characteristics, functional status). Results: Frailty as defined K-FRAIL significantly higher in group (7.6%) than non-asthma (4.9%). phenotype component showed that illness severity were more severe group. After adjusting, associated with increased risk (OR 1.45; 95% confidence interval [CI] 1.01–2.09) compared Conclusions: might be population. may only asthma, but also other diseases. So, evidence needed establish this association.

Language: Английский

Citations

0
Exploring the Role of Inflammatory Cytokines in Cervical cancer Pathogenesis: Evidence from Mendelian Randomization Analysis DOI Creative Commons
Yuqiang Zhang,

D.Y. Luo,

Xinguang Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background: Cervical cancer (CC) is a prevalent malignancy worldwide, which seriously threatens women's quality of life and health. Although CC etiology remains uncertain, mounting evidence suggests that inflammatory cytokines (CKs) contribute to pathogenesis. Nonetheless, more research required determine if there causal connection between them. Therefore, our study performed Mendelian randomized (MR) investigate the link CKs CC. Methods: The CK data are derived from two European population databases: one containing 41 other 91 CKs. came UK Biobank (n ≤ 408961), including 1659 cases 381902 controls ancestry. Our employed inverse variance weighted, MR-Egger, weighted median, mode analyze relation Additionally, multiple sensitivity analyses, MRE intercept test, MR-PRESSO Leave One Out, were deployed further validate robustness results. Eventually, reverse MR analysis was carried out. RESULTS: results showed increase Monokine triggered by gamma interferon )INF-γ( level negatively correlated with (odds ratio (OR) = 0.84, 95% confidence interval (95% CI): 0.72–0.99, P 0.044). Elevated cystatin D (CysD), Interleukin-8 (IL-8), Leukemia Inhibitory Factor (LIF), Monocyte chemoattractant protein 2 (MCP-2) levels positively occurrence (OR 1.18, CI:1.02–1.36, 0.025; OR 1.41, CI:1.02–1.95, 0.035; 1.39, CI:1.00–1.94, 0.044; 1.76, CI:1.25–2.47, 9×10–4), aligned analyses Reverse Results had no effect on 132 Conclusion: Herein, demonstrated potential INF-γ, CysD, IL-8, LIF, MCP-2 risk. role in development needs investigation.

Language: Английский

Citations

0