Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

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Intersections and Challenges in the Management of Acute Coronary Syndrome and Stroke: Pathophysiology, Treatment Dilemmas, and Integrated Prevention Strategies

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2354 - 2354

Published: March 29, 2025

Acute coronary syndrome (ACS) and stroke are interconnected conditions that often share risk factors such as atherosclerosis, thrombosis, systemic inflammation. When these events occur simultaneously, they present unique diagnostic therapeutic challenges. This review explores the pathophysiological mechanisms linking ACS stroke, including common pathways like plaque instability, cardioembolism, endothelial dysfunction, while highlighting distinct features of ischemic hemorrhagic strokes. The manuscript provides an overview strategies, emphasizing role biomarkers, advanced neuroimaging, stratification tools in guiding acute management. Furthermore, delves into treatment approach, need to balance reperfusion therapies for with thrombolysis or thrombectomy carefully managing challenges posed by anticoagulation cases complicated bleeding. Long-term strategies secondary prevention examined, antithrombotic regimens tailored dual thrombosis bleeding, well lipid-lowering blood pressure Future perspectives highlight potential novel pharmacological agents, neuroprotective therapies, AI-driven enhance patient outcomes. underscores importance integrated, multidisciplinary care identifies key areas future research optimize management high-risk patients.

Language: Английский

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Bi-directional causal association between 17 neurosurgical diseases and three emotional disorders: perspective from Mendelian randomization analysis

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Background Although numerous studies have reported correlations between emotional disorders and neurosurgical conditions, their causal relationships is not convincing. Therefore, we seek to comprehensively investigate the connection two using bidirectional Mendelian randomization studies. Methods The GWAS aggregated data encompassed 17 types of diseases (including cerebrovascular diseases, functional disorders, central nervous system neoplasms, spinal cord other brain conditions) 3 (anxiety, mania, depression), sourced from IEU FINNGEN. The primary analysis method applied was inverse variance-weighted (IVW) analysis, supplemented by MR-Egger weighted median methods ensure robust estimates. A series sensitivity analyses, including Cochran’s Q test, regression, leave-one-out were conducted detect pleiotropy or heterogeneity. Results IVW estimates indicated that trigeminal neuralgia significantly associated with risk mania (p=0.002, odds ratio [OR]=1.008, 95 % confidence interval [CI] = 1.003 1.014), a higher genetic predisposition congenital malformations may reduce development depression OR= 0.996; %CI 0.992 0.998) effect on transient ischemic attack (IVW, P=0.004, (p=0.004, OR 4.141; 1.560 10.988). results comprehensive analyses consistent main causality estimate. No heterogeneity detected in our MR study. Conclusions Our large-scaled predispose patients while depression, particular, increases vulnerability stroke.

Language: Английский

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Self-Assembly of Iron Oxide Nanoparticles for Microvascular Magnetic Resonance Imaging

Published: Jan. 1, 2024

Language: Английский

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