Investigating Risk Factors for Meibomian Gland Dysfunction and Loss Among Young Medical Trainees DOI Creative Commons
Marjan Farid, Christine Kim,

Aidin Spina

et al.

Cornea, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Purpose: To determine risk factors for meibomian gland disease and associated structural abnormalities in meibography among young medical trainees. Methods: This study included 84 students residents younger than 45 years. All participants completed an ocular history lifestyle questionnaire the standardized patient evaluation of eye dryness (SPEED) II questionnaire. Meibomian (MG) dropout changes were evaluated using scored by 2 graders meiboscores. Statistical analysis aimed to identify MG loss factors. Results: Eighty-four individuals participated, 168 images reviewed. Previous contact lens (CL) use (n = 88) demonstrated increased ( P 0.007). Correlation revealed positive associations between both frequency (Spearman r 0.212, 0.003) duration 0.271, <0.001) CL use. Eye makeup users 112) showed greater nonusers 56, 0.030), particularly eyeliner 102) eyeshadow 100) showing meiboscores 0.020 0.040, respectively). Self-reported screen time SPEED scores did not correlate with >0.05). Conclusions: In a trainee population, where age-related are reduced, previous significant loss. Frequency length wear affect severity. usage also affected Highlighting incongruence symptoms signs, no relationship integrity.

Language: Английский

Potential New Target for Dry Eye Disease—Oxidative Stress DOI Creative Commons
Jinghua Bu, Yanbo Liu, Rongrong Zhang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 422 - 422

Published: March 29, 2024

Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It characterized by loss of tear film homeostasis and accompanied symptoms that may potentially result in damage to surface even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, ethanol consumption. As its prevalence continues rise, has garnered considerable attention, prompting exploration potential new therapeutic targets. Recent studies have found when production ROS exceeds capacity antioxidant defense system on surface, oxidative stress ensues, leading cellular apoptosis further damage. These events can exacerbate inflammation responses, increasing levels promoting vicious cycle DED. Therefore, given central role reactive oxygen species DED, strategies involving antioxidants emerged novel approach treatment. This review aims enhance our understanding intricate relationship between thereby providing directions explore innovative approaches this complex disorder.

Language: Английский

Citations

22
An Injectable Copolymer for in Situ Lubrication Effectively Relieves Dry Eye Disease DOI
Lan Yang, Jinghua Li,

Bowen Zhou

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 884 - 890

Published: Feb. 7, 2025

Language: Английский

Citations

2
Identification of Microplastics in Human Tear Fluid and Meibum: Implications for Dry Eye Disease Pathogenesis DOI Creative Commons
Jingyi Wang, Huanmin Kang,

Xixuan Huang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137635 - 137635

Published: Feb. 18, 2025

Language: Английский

Citations

1
Therapeutic benefits of glycerol in dry eye disease DOI Creative Commons

Victoria Ronderos,

Wendy B. Bollag

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 15, 2025

Dry eye disease (DED) is one of the most commonly diagnosed disorders, with a prevalence ranging from 5 to 50%, depending on geographic location. DED multifactorial disorder tears and ocular surface, which results in symptoms discomfort, visual disturbance, tear film instability potential damage surface. It also accompanied by increased osmolarity inflammation surface eye. Multiple therapeutic agents have been used treat DED, glycerol emerging as promising component ophthalmic preparations, due its humectant, lubricant, demulcent, osmoprotective properties. This review aims evaluate current evidence concerning benefits managing focusing possible mechanisms action, clinical efficacy, advantages over other treatments.

Language: Английский

Citations

0
Corneal protective effects of a new ophthalmic formulation based on vitamin B12 and sodium hyaluronate DOI Creative Commons
Francesca Lazzara, Federica Conti, Grazia Maugeri

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 31, 2025

Corneal damage can happen due to a variety of insults, including environmental factors and iatrogenic issues. For instance, the corneal epithelium is sensitive oxidative stress caused by reactive oxygen species (ROS) or ultraviolet B (UVB) radiation. Moreover, strictly correlated inflammatory processes impair reparative wound healing mechanism. protection after remains an unmet medical need that requires urgent management. Sodium hyaluronate known protect cornea against injury. Additionally, vitamin B12 good candidate for counteracting damage, helping preserve visual functions. The present study aimed investigate potential protective effect ophthalmic formulation based on 0.01% B12% 0.15% sodium (DROPYAL EVO) compared other formulations containing trehalose (TRIMIX THEALOZ DUO). Two different in vitro models were carried out epithelial cells exposed hydrogen peroxide (H2O2, 1 mM) UVB (20 mJ/cm2). Cell viability, cytotoxicity, ROS production, mRNA expression pro-inflammatory cytokines (TNF-α IL-1β) assessed MTT, LDH, 2',7'-dichlorofluorescein diacetate (DCFDA) assays Real-time PCR, respectively. ability affect process was at time points scratch assay. eye drops able significantly counteract H2O2 stimulus radiation, terms production expression. obtained better outcomes closure 36 h 48 scratching cells, two trehalose. Vitamin potentially enhances hyaluronate, accelerating modulating inflammation. B12, combination with could represent promising approach managing damage. Further clinical investigations are needed confirm this data.

Language: Английский

Citations

0
Recalcitrant Dry Eye Disease in a 31-Year-Old Female: Favorable Outcomes Following Complete Ocular Lavage Facilitated by an Irrigating Eyelid Retractor DOI Open Access

Sathi Maiti,

Srinivas Sai A. Kondapalli,

Laura M. Periman

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

This report explores the management of an otherwise healthy 31-year-old Caucasian female with chronic, refractory dry eye disease (DED) unresponsive to extensive conventional therapies. The initial treatment included artificial tears, cyclosporine, hypochlorous acid spray, and thermal eyelid pulsation, which provided limited relief. Progressive therapeutic interventions, such as intense pulsed light, varenicline nasal perfluorohexyloctane drops, platelet-rich plasma, topical antibiotics, resulted in only modest improvement over 15 months. Persistent symptoms corneal staining prompted implementation a novel treatment: high-pressure ocular surface lavage using irrigating retractor (Rinsada®) preservative-free saline. Post-lavage, patient experienced immediate significant symptomatic relief, marked noted on slit lamp examination. Continued was observed two weeks following procedure. underscores potential saline irrigation for addressing inflammatory mediators biofilm surface. enabled precise effective palpebral conjunctiva fornices, reducing load resetting technique represents promising adjunctive therapy recalcitrant DED, offering rapid symptom relief improved clinical outcomes. Further studies are warranted validate these findings optimize care.

Language: Английский

Citations

0
Implications of nanotechnology for the treatment of Dry Eye Disease: Recent advances DOI
Roghayyeh Baghban,

Shahram Bamdad,

Alireza Attar

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125355 - 125355

Published: Feb. 1, 2025

Language: Английский

Citations

0
Role of Chinese Medicine Monomers in Dry Eye Disease: Breaking the Vicious Cycle of Inflammation DOI Creative Commons

Zhuoyu Hu,

Xiangdong Chen, Qi Hu

et al.

Pharmacology Research & Perspectives, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 20, 2025

Dry eye disease (DED) is a chronically inflammatory ocular surface disorder of unknown pathogenesis. Anti-inflammatory medications, artificial tears, autologous serum, and LipiFlow have been shown to be highly beneficial in alleviating symptoms. Nevertheless, these interventions often provide only short-term results do not address the underlying problems disease. There growing evidence that risk DED associated with vicious cycle inflammation. This inflammation produced by interaction several factors, including tear film hyperosmolarity, instability, inflammation, apoptosis. Chinese medicine monomers, distinguished their multicomponent multitarget advantages, help treat modulating status, inhibiting responses, apoptosis, providing new way thinking management medicine.

Language: Английский

Citations

0
Advances in understanding the role and mechanism of the cGAS-STING signaling pathway in ocular diseases DOI Creative Commons
Mengdi Zhang, Jiayu Xu,

Wenjia Qu

et al.

Immunological Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 8, 2025

The cGAS-STING signaling pathway plays a critical role in the immune defense against DNA viruses and autoimmunity, coordinating cascade of events that enhance cytokine production, particularly type I interferons. This review summarizes recent advancements understanding pathway's impact on various ocular diseases, including age-related macular degeneration (AMD), diabetic retinopathy, uveitis. Activation this by cytoplasmic from either damaged retinal cells or external pathogens induces inflammatory responses may accelerate disease progression. Moreover, paper explores new therapeutic approaches target pathway, offering insights into how modulation could reduce inflammation improve clinical outcomes. emerging research area suggests potential for innovative treatments degenerative conditions.

Language: Английский

Citations

0
Biogenic Amino Acid Cross-Linked Hyaluronic Acid Nanoparticles Containing Dexamethasone for the Treatment of Dry Eye Syndrome DOI
Ajit Mishra, Jitu Halder,

Ivy Saha

et al.

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: March 27, 2025

Language: Английский

Citations

0