A Novel Nomogram Developed Based on Preoperative Immune Inflammation-Related Indicators for the Prediction of Postoperative Delirium Risk in Elderly Hip Fracture Cases: A Single-Center Retrospective Cohort Study DOI Creative Commons
Xiao Chen,

Yuanhe Fan,

Hong-Liang Tu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7155 - 7169

Published: Oct. 1, 2024

Objective: Postoperative delirium (POD) commonly occurs in elderly individuals following hip fracture surgery, with unclear pathophysiological mechanism. Inflammation is a known factor affecting the onset of delirium. The current work aimed to examine associations preoperative immune inflammation-related indicators POD occurrence cases surgery. Methods: retrospective cohort study included 437 administered surgery from January 2018 December 2023. clinicodemographic data and laboratory findings all were retrospectively analyzed. Immune assessed, eg, MLR, NLR PLR, as well SII SIRI. bootstrap method was employed assign at 7:3 training (48 258 no-POD groups, respectively) internal validation (13 118 cohorts. Next, LASSO, univariable multivariable logistic regression analyses applied determine risk factors cohort, based on which nomogram model built. obtained examined for accuracy by calibration plot analysis. Finally, nomogram's clinical value assessed decision curve analysis (DCA), followed cohort. Results: Of cases, 61 developed POD, indicating incidence 13.96%. LASSO revealed SIRI independently predicted had an area under (AUC) 0.991 (95% CI 0.983~0.998) versus 0.986 0.966~1.000) Calibration nomogram-predicted actual probabilities line. DCA demonstrated novel could confer net benefits prediction Conclusion: predict Keywords: postoperative delirium, fracture, elderly, inflammation related indicators,

Language: Английский

Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation DOI
Jianhui Liu, Cheng Li, Junyan Yao

et al.

Science China Life Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
Study on the predictive model of delirium risk after surgery for elderly hip fractures based on meta-analysis DOI
Weiliang Wan, Liyun Li, Zhuan Zou

et al.

European Geriatric Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 5, 2024

Language: Английский

Citations

1
Effects of esketamine combined with dexmedetomidine on postoperative delirium and quality of recovery in elderly patients undergoing thoracoscopic radical lung cancer surgery: a randomized controlled trial DOI Open Access

Cong-Li Zhang,

Yan Yan, Yang Zhang

et al.

CNS Spectrums, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Nov. 20, 2024

This study aimed to investigate the effects of esketamine (Esk) combined with dexmedetomidine (Dex) on postoperative delirium (POD) and quality recovery (QoR) in elderly patients undergoing thoracoscopic radical lung cancer surgery.

Language: Английский

Citations

1
A Novel Nomogram Developed Based on Preoperative Immune Inflammation-Related Indicators for the Prediction of Postoperative Delirium Risk in Elderly Hip Fracture Cases: A Single-Center Retrospective Cohort Study DOI Creative Commons
Xiao Chen,

Yuanhe Fan,

Hong-Liang Tu

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 7155 - 7169

Published: Oct. 1, 2024

Objective: Postoperative delirium (POD) commonly occurs in elderly individuals following hip fracture surgery, with unclear pathophysiological mechanism. Inflammation is a known factor affecting the onset of delirium. The current work aimed to examine associations preoperative immune inflammation-related indicators POD occurrence cases surgery. Methods: retrospective cohort study included 437 administered surgery from January 2018 December 2023. clinicodemographic data and laboratory findings all were retrospectively analyzed. Immune assessed, eg, MLR, NLR PLR, as well SII SIRI. bootstrap method was employed assign at 7:3 training (48 258 no-POD groups, respectively) internal validation (13 118 cohorts. Next, LASSO, univariable multivariable logistic regression analyses applied determine risk factors cohort, based on which nomogram model built. obtained examined for accuracy by calibration plot analysis. Finally, nomogram's clinical value assessed decision curve analysis (DCA), followed cohort. Results: Of cases, 61 developed POD, indicating incidence 13.96%. LASSO revealed SIRI independently predicted had an area under (AUC) 0.991 (95% CI 0.983~0.998) versus 0.986 0.966~1.000) Calibration nomogram-predicted actual probabilities line. DCA demonstrated novel could confer net benefits prediction Conclusion: predict Keywords: postoperative delirium, fracture, elderly, inflammation related indicators,

Language: Английский

Citations

0