Abstract
Microbial
pathogens
have
threatened
the
world
due
to
their
pathogenicity
and
ability
spread
in
communities.
The
conventional
laboratory‐based
diagnostics
of
microbes
such
as
bacteria
viruses
need
bulky
expensive
experimental
instruments
skilled
personnel
which
limits
usage
resource‐limited
settings.
biosensors‐based
point‐of‐care
(POC)
shown
huge
potential
detect
microbial
a
faster,
cost‐effective,
user‐friendly
manner.
use
various
transducers
electrochemical
optical
along
with
microfluidic
integrated
biosensors
further
enhances
sensitivity
selectivity
detection.
Additionally,
microfluidic‐based
offer
advantages
multiplexed
detection
analyte
deal
nanoliters
volume
fluid
an
portable
platform.
In
present
review,
we
discussed
design
fabrication
POCT
devices
for
include
bacteria,
viruses,
fungi,
parasites.
techniques
current
advances
this
field
terms
platforms
that
mainly
microfluidic‐
based
approaches
smartphone
Internet‐of‐things
(IoT)
Internet‐of‐Medical‐Things
(IoMT)
systems
been
highlighted.
Further,
availability
commercial
will
be
briefed.
end,
challenges
while
POC
expected
future
biosensing
discussed.
biosensor‐based
IoT/IoMT
usually
collect
data
track
community
infectious
diseases
would
beneficial
better
preparedness
futuristic
pandemics
is
prevent
social
economic
losses.
Ageing Research Reviews,
Journal Year:
2023,
Volume and Issue:
91, P. 102068 - 102068
Published: Sept. 12, 2023
Alzheimer's
disease
(AD)
represents
the
most
frequent
type
of
dementia
in
elderly
people.
Two
major
forms
exist:
sporadic
-
causes
which
have
not
yet
been
fully
understood
and
familial
inherited
within
families
from
generation
to
generation,
with
a
clear
autosomal
dominant
transmission
mutations
Presenilin
1
(PSEN1),
2
(PSEN2)
or
Amyloid
Precursors
Protein
(APP)
genes.
The
main
hallmark
AD
consists
extracellular
deposits
amyloid-beta
(Aβ)
peptide
intracellular
hyperphosphorylated
form
tau
protein.
An
ever-growing
body
research
supports
viral
infectious
hypothesis
AD.
In
particular,
it
has
shown
that
several
herpes
viruses
(i.e.,
HHV-1,
HHV-2,
HHV-3
varicella
zoster
virus,
HHV-4
Epstein
Barr
HHV-5
cytomegalovirus,
HHV-6A
B,
HHV-7),
flaviviruses
Zika
Dengue
fever
Japanese
encephalitis
virus)
as
well
Human
Immunodeficiency
Virus
(HIV),
hepatitis
(HAV,
HBV,
HCV,
HDV,
HEV),
SARS-CoV2,
Ljungan
virus
(LV),
Influenza
A
Borna
could
increase
risk
Here,
we
summarized
discussed
these
results.
Based
on
findings,
significant
issues
for
future
studies
are
also
put
forward.
Microbiology Spectrum,
Journal Year:
2022,
Volume and Issue:
10(1)
Published: Feb. 2, 2022
In
clinical
settings,
rapid
and
accurate
diagnosis
of
antibiotic
resistance
is
essential
for
the
efficient
treatment
bacterial
infections.
Conventional
methods
testing
are
time
consuming,
while
molecular
such
as
PCR-based
might
not
accurately
reflect
phenotypic
resistance.
Thus,
fast
analysis
in
high
demand
applications.
this
pilot
study,
we
isolated
7
carbapenem-sensitive
Klebsiella
pneumoniae
(CSKP)
strains
8
carbapenem-resistant
(CRKP)
from
samples.
Surface-enhanced
Raman
spectroscopy
(SERS)
a
label-free
noninvasive
method
was
employed
discriminating
CSKP
CRKP
through
computational
analysis.
Eight
supervised
machine
learning
algorithms
were
applied
sample
According
to
results,
all
could
successfully
predict
carbapenem
sensitivity
K.
pneumoniae,
with
convolutional
neural
network
(CNN)
algorithm
on
top
other
methods.
Taken
together,
study
confirmed
application
potentials
surface-enhanced
discrimination
different
profiles.
IMPORTANCE
With
low-cost,
label-free,
nondestructive
features,
becoming
an
attractive
technique
great
potential
discriminate
analyzed
surfaced-enhanced
spectra
via
algorithms,
which
SERS
Abstract
Microbial
pathogens
have
threatened
the
world
due
to
their
pathogenicity
and
ability
spread
in
communities.
The
conventional
laboratory‐based
diagnostics
of
microbes
such
as
bacteria
viruses
need
bulky
expensive
experimental
instruments
skilled
personnel
which
limits
usage
resource‐limited
settings.
biosensors‐based
point‐of‐care
(POC)
shown
huge
potential
detect
microbial
a
faster,
cost‐effective,
user‐friendly
manner.
use
various
transducers
electrochemical
optical
along
with
microfluidic
integrated
biosensors
further
enhances
sensitivity
selectivity
detection.
Additionally,
microfluidic‐based
offer
advantages
multiplexed
detection
analyte
deal
nanoliters
volume
fluid
an
portable
platform.
In
present
review,
we
discussed
design
fabrication
POCT
devices
for
include
bacteria,
viruses,
fungi,
parasites.
techniques
current
advances
this
field
terms
platforms
that
mainly
microfluidic‐
based
approaches
smartphone
Internet‐of‐things
(IoT)
Internet‐of‐Medical‐Things
(IoMT)
systems
been
highlighted.
Further,
availability
commercial
will
be
briefed.
end,
challenges
while
POC
expected
future
biosensing
discussed.
biosensor‐based
IoT/IoMT
usually
collect
data
track
community
infectious
diseases
would
beneficial
better
preparedness
futuristic
pandemics
is
prevent
social
economic
losses.
