Review of antibiotic-resistant bacteria and antibiotic resistance genes within the one health framework

Infection Ecology & Epidemiology, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 13, 2024

Background: The interdisciplinary One Health (OH) approach recognizes that human, animal, and environmental health are all interconnected. Its ultimate goal is to promote optimal for through the exploration of these relationships. Antibiotic resistance (AR) a public challenge has been primarily addressed within context human clinical settings. However, it become increasingly evident antibiotic resistant bacteria (ARB) genes (ARGs) confer transmitted circulated humans, animals, environment. Therefore, effectively address this issue, must also be considered an livestock/wildlife problem.

Language: Английский

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Efficient synergistic photocatalytic degradation by sunlight-driven natural tourmaline modified g-C3N4 interface electric field

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: 361, P. 131496 - 131496

Published: Jan. 7, 2025

Language: Английский

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Ecological Consequences of Antibiotics Pollution in Sub-Saharan Africa: Understanding Sources, Pathways, and Potential Implications

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100475 - 100475

Published: Jan. 1, 2025

Language: Английский

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Metagenomic assembly reveals hosts and mobility of common antibiotic resistome in animal manure and commercial compost

Environmental Microbiome, Journal Year: 2022, Volume and Issue: 17(1)

Published: Aug. 11, 2022

Antibiotics and antibiotic resistance genes (ARGs) used in intensive animal farming threaten human health worldwide; however, the common resistome, ARG mobility, host composition different manures mixed manure composts remain unclear. In present study, metagenomic assembly cross-sample mapping were to comprehensively decipher resistome its potential mobility hosts composts.In total, 201 ARGs shared among (layer, broiler, swine, beef cow, dairy cow) accounted for 86-99% of total relative abundance ARGs. Except multidrug, sulfonamide, trimethoprim genes, most was significantly lower than that manure. Procrustes analysis indicated residues positively correlated with but not composts. More 75% subtypes between plasmids chromosomes our samples. Transposases could play a pivotal role mediating transfer phyla composting. Cross-sample contigs carrying showed had preference on species, dominant genus shifted from Enterococcus Pseudomonas The broad range linking diverse mobile genetic elements (MGEs) two key factors ARGs, such as sul1 aadA, which survive during multidrug represented pathogenic antibiotic-resistant bacteria be effectively controlled by composting.Our experiments revealed manure, classified quantified hosts, assessed Composting can mitigate altering bacterial hosts; persistent escape removal because MGEs. Our findings provide an overall background source tracking, risk assessment, control livestock

Language: Английский

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A sustainable waste-to-protein system to maximise waste resource utilisation for developing food- and feed-grade protein solutions

Green Chemistry, Journal Year: 2022, Volume and Issue: 25(3), P. 808 - 832

Published: Dec. 8, 2022

Analysis of an integrated waste-to-protein system for a sustainable protein future to ameliorate the rising global hunger pandemic.

Language: Английский

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Insights into the impact of manure on the environmental antibiotic residues and resistance pool

Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 16, 2022

The intensive use of antibiotics in the veterinary sector, linked to application manure-derived amendments agriculture, translates into increased environmental levels chemical residues, AR bacteria (ARB) and antibiotic resistance genes (ARG). aim this review was evaluate current evidence regarding impact animal farming manure on pool environment. Several studies reported correlations between prevalence clinically relevant ARB amount classes used (high rates being for medically important such as penicillins, tetracyclines, sulfonamides fluoroquinolones). However, results are difficult compare, due diversity antimicrobials quantification techniques different amounts types antibiotics, exhibiting various degradation times, given feed countries. soils fertilized with products harbor a higher chronic abundance ARB, multiple ARG an enriched associated mobilome, which is also sometimes seen crops grown amended soils. Different processing have efficiencies removal ARGs, but there only small data from commercial farms. efficiency sludge anaerobic digestion appears be dependent microbial communities composition, ARB/ARG operating temperature (mesophilic vs. thermophilic conditions). Composting seems reduce or eliminate most enteric bacteria, representative more rapidly effectively than lagoon storage. Our highlights that despite body research accumulated last years, still knowledge gaps contribution AMR emergence, accumulation, spread risk human exposure countries high clinical rates. Land microbiome before after application, treatment decreasing natural environments along food chain must investigated depth, covering geographical regions using harmonized methodologies. support stakeholders required development specific best practices prudent - cautious farm animals. reserve medicine unprescribed should stopped farms limited. This integrated approach needed determine optimal conditions ARG, formulate recommendations livestock treatment, storage handling procedures translate them practical on-farm management decisions, ultimately prevent population.

Language: Английский

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Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

BioMed Research International, Journal Year: 2023, Volume and Issue: 2023(1)

Published: Jan. 1, 2023

Antimicrobial resistance (AMR) is a ubiquitous public health menace. AMR emergence causes complications in treating infections contributing to an upsurge the mortality rate. The epidemic of sync with high utilization rate antimicrobial drugs signifies alarming situation for fleet recovery both animals and humans. resistant species calls new treatments therapeutics. Current records propose that drug dependency, veterinary medicine, agricultural application, vaccination reluctance are primary etymology gene spread. Recently, several encouraging avenues have been presented contest resistance, such as antivirulent therapy, passive immunization, peptides, vaccines, phage botanical liposomal nanoparticles. Most these therapies used cutting‐edge methodologies downplay antibacterial subdue pressure, which featured motive discussion this review article. can fade away through potential use current therapeutics, advancement susceptibility testing, diagnostic prompt clinical response, probing pharmacodynamic properties antimicrobials. It also needs promote future research on contemporary methods maintain host homeostasis after caused by AMR. Referable microbial ability break there great ultimatum using not only appropriate advanced but other neoteric diverse

Language: Английский

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Antimicrobial Resistance and Clonal Lineages of Escherichia coli from Food-Producing Animals

Antibiotics, Journal Year: 2023, Volume and Issue: 12(6), P. 1061 - 1061

Published: June 15, 2023

Escherichia coli are one of the most important pathogenic bacteria readily found in livestock and widely studied as an indicator that carries drug-resistant genes between humans, animals, environment. The use antimicrobials food chain, particularly food-producing is recognized a significant contributor to development spread antimicrobial resistance (AMR) can be transferred from farm through food-chain. objective this review highlight background more specifically, study clonal lineages profiles observed E. coli, well extended spectrum beta-lactamases (ESBL) producing set food-production animals with greater relevance consumption, such pigs, poultry, cattle, fish farming rabbits. Regarding prevalence ESBL-producing among high-to-moderate was observed, highest rates tetracycline ampicillin detected different farms all geographic regions. Worldwide pandemic clones high-risk zoonotic have been identified some these already disseminated niches, environment humans. A better understanding epidemiology urgently needed. Animal production major causes antibiotic problem worldwide One Health approach

Language: Английский

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Persistence and potential risks of tetracyclines and their transformation products in two typical different animal manure composting treatments

Environmental Pollution, Journal Year: 2023, Volume and Issue: 341, P. 122904 - 122904

Published: Nov. 10, 2023

Language: Английский

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Current State of Knowledge Regarding WHO High Priority Pathogens—Resistance Mechanisms and Proposed Solutions through Candidates Such as Essential Oils: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9727 - 9727

Published: June 4, 2023

Combating antimicrobial resistance (AMR) is among the 10 global health issues identified by World Health Organization (WHO) in 2021. While AMR a naturally occurring process, inappropriate use of antibiotics different settings and legislative gaps has led to its rapid progression. As result, grown into serious menace that impacts not only humans but also animals and, ultimately, entire environment. Thus, effective prophylactic measures, as well more potent non-toxic agents, are pressingly needed. The activity essential oils (EOs) supported consistent research field. Although EOs have been used for centuries, they newcomers when it comes managing infections clinical settings; mainly because methodological largely non-overlapping there insufficient data regarding EOs' vivo toxicity. This review considers concept main determinants, modality which issue globally addressed potential alternative or auxiliary therapy. focus shifted towards pathogenesis, mechanism several against six high priority pathogens listed WHO 2017, new therapeutic solutions required.

Language: Английский

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