Genomic surveillance for antimicrobial resistance — a One Health perspective

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(2), P. 142 - 157

Published: Sept. 25, 2023

Language: Английский

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Potential Causes of Spread of Antimicrobial Resistance and Preventive Measures in One Health Perspective-A Review

Infection and Drug Resistance, Journal Year: 2023, Volume and Issue: Volume 16, P. 7515 - 7545

Published: Dec. 1, 2023

Abstract: Antimicrobial resistance, referring to microorganisms' capability subsist and proliferate even when there are antimicrobials is a foremost threat public health globally. The appearance of antimicrobial resistance can be ascribed anthropological, animal, environmental factors. Human-related causes include overuse misuse in medicine, antibiotic-containing cosmetics biocides utilization, inadequate sanitation hygiene settings. Prophylactic therapeutic overuse, using as feed additives, microbes resistant antibiotics genes animal excreta, residue found animal-origin food excreta animals related contributive factors for the antibiotic emergence spread. Environmental including naturally existing genes, improper disposal unused antimicrobials, contamination from waste settings, farms, pharmaceutical industries, use agricultural chemicals facilitatet its Wildlife has plausible role Adopting one-health approach involving properly humans, improving spaces implementing coordinated governmental regulations crucial combating resistance. Collaborative cooperative involvement stakeholders public, veterinary ecological sectors circumvent problem effectively. Keywords: one health, gene, environment, wildlife

Language: Английский

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Soil and Phytomicrobiome for Plant Disease Suppression and Management under Climate Change: A Review

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2736 - 2736

Published: July 23, 2023

The phytomicrobiome plays a crucial role in soil and ecosystem health, encompassing both beneficial members providing critical goods services pathogens threatening food safety security. potential benefits of harnessing the power for plant disease suppression management are indisputable interest agriculture but also forestry landscaping. Indeed, diseases can be mitigated by situ manipulations resident microorganisms through agronomic practices (such as minimum tillage, crop rotation, cover cropping, organic mulching, etc.) well applying microbial inoculants. However, numerous challenges, such lack standardized methods microbiome analysis difficulty translating research findings into practical applications at stake. Moreover, climate change is affecting distribution, abundance, virulence many pathogens, while altering functioning, further compounding strategies. Here, we will first review literature demonstrating how agricultural have been found effective promoting health enhancing suppressiveness mitigation shift phytomicrobiome. Challenges barriers to identification use then discussed before focusing on impacts functioning outcome.

Language: Английский

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Wastewater treatment plants, an “escape gate” for ESCAPE pathogens

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: May 24, 2023

Antibiotics are an essential tool of modern medicine, contributing to significantly decreasing mortality and morbidity rates from infectious diseases. However, persistent misuse these drugs has accelerated the evolution antibiotic resistance, negatively impacting clinical practice. The environment contributes both transmission resistance. From all anthropically polluted aquatic environments, wastewater treatment plants (WWTPs) probably main reservoirs resistant pathogens. They should be regarded as critical control points for preventing or reducing release antibiotics, antibiotic-resistant bacteria (ARB), antibiotic-resistance genes (ARGs) into natural environment. This review focuses on fate pathogens Enterococcus faecium , Staphylococcus aureus Clostridium difficile Acinetobacter baumannii Pseudomonas aeruginosa Enterobacteriaceae spp. (ESCAPE) in WWTPs. All ESCAPE pathogen species, including high-risk clones resistance determinants last-resort antibiotics such carbapenems, colistin, multi-drug platforms, were detected wastewater. whole genome sequencing studies demonstrate clonal relationships dissemination Gram-negative species via hospital effluents enrichment virulence S. enterococci Therefore, efficiency different processes regarding removal clinically relevant ARB ARGs, well influence water quality factors their performance, explored monitored, along with development more effective treatments appropriate indicators (ESCAPE and/or ARGs). knowledge will allow standards point sources consolidate WWTP barrier role against environmental public health AR threats.

Language: Английский

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Antibiotics and microplastics in manure and surrounding soil of farms in the Loess Plateau: Occurrence and correlation

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 465, P. 133434 - 133434

Published: Jan. 4, 2024

Language: Английский

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Veterinary Drug Residues in the Food Chain as an Emerging Public Health Threat: Sources, Analytical Methods, Health Impacts, and Preventive Measures

Foods, Journal Year: 2024, Volume and Issue: 13(11), P. 1629 - 1629

Published: May 23, 2024

Veterinary medications are necessary for both contemporary animal husbandry and food production, but their residues can linger in foods obtained from animals pose a dangerous human risk. In this review, we aim to highlight the sources, occurrence, exposure pathways, health effects of drug food-animal products. Following usage veterinary medications, pharmacologically active compounds known as be found food, environment, or animals. They cause major concerns people, including antibiotic resistance development, development cancer, teratogenic effects, hypersensitivity, disruption normal intestinal flora. Drug products originate variety water contamination, extra-label use, ignoring withdrawal periods. This review also examines how humans exposed through drinking water, air, dust, discusses various analytical techniques identifying these food. Furthermore, suggest some potential solutions prevent reduce such implementing periods, monitoring programs, education campaigns, new technologies that crucial safeguarding public health. underscores urgency addressing significant emerging threat, calling collaborative efforts researchers, policymakers, industry stakeholders develop sustainable ensure safety global supply chain.

Language: Английский

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From Herd Health to Public Health: Digital Tools for Combating Antibiotic Resistance in Dairy Farms

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 634 - 634

Published: July 9, 2024

The emergence of antimicrobial resistance (AMR) is a significant threat to global food security, human health, and the future livestock production. Higher rates use in dairy farming sheer lack new antimicrobials available for focused attention on question how production sector contributed development AMR paved path toward taking action curtail it targeted type farms. This paper aims provide an introduction phenomenon that has gained considerable recent past due its ever-increasing impact, drugs, farms, seeks discuss possibilities approaches such as digital health monitoring precision farming. Using sensors, data, knowledge, automation, etc., monitoring, well Precision Livestock Farming (PLF), expected enhance control minimize disease usage. work presents literature review current status trends understanding concept PLF, presentation usefulness PLF preventing AMR. study also analyses strengths weaknesses adopting incorporating technologies artificial intelligence areas further level use.

Language: Английский

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Potential of Pine Biochar to Mitigate Bacterial Hazards Present in Recycled Manure Solids from Dairy Cows

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(1), P. 43 - 43

Published: Jan. 10, 2025

The use of recycled manure solids (RMS) as cow bedding in dairy farms poses concerns due to its potential harbor pathogenic and antimicrobial-resistant bacteria. This study evaluated the impact RMS supplementation with biochar at three concentrations (2.5%, 5%, 10%) on bacterial counts antimicrobial resistance virulence profiles Escherichia coli Enterococcus isolates. results show that did not promote a significant reduction numbers. Overall, there were no changes isolates’ or profiles, none isolates obtained classified high moderate threats based their MAR VIR indexes. most found present control samples. A phylogenetic analysis E. allowed us identify phylogroup D strains, predominantly supplemented 2.5% 10% biochar, which are associated higher resistance. These findings indicate tested effective significantly reducing risks RMS. Further research is needed evaluate different formulations concentrations, aiming optimize for supplementation.

Language: Английский

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A review on the effects of discharging conventionally treated livestock waste to the environmental resistome

Environmental Pollution, Journal Year: 2023, Volume and Issue: 338, P. 122643 - 122643

Published: Sept. 27, 2023

Language: Английский

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Roadmap for the integration of environmental microbiomes in risk assessments under EFSA's remit

EFSA Supporting Publications, Journal Year: 2024, Volume and Issue: 21(2)

Published: Feb. 1, 2024

Scientific interest in the use of environmental microbiomes for risk assessment is rapidly growing, as exemplified by various EFSA opinions. In absence official regulatory guidelines on how to integrate assessment, aims this report are therefore determine whether microbiome studies can be used such purposes, and propose a roadmap integration assessments under EFSA's remit. The identifies current gaps (in terms knowledge from technical point view) barriers that might delay implementation methods, offers recommendations standardised (multi-)omics techniques purposes. Our main findings identified five priorities: (i) defining core (what it encompasses what made of, including identification bioindicators) assess impact any type disturbance; (ii) standardising methodologies protocols, sampling interpretation, guarantee comparability analyses; (iii) developing tools facilitate interpretation; (iv) collecting microbiome-based data shared, curated maintained databases; (v) setting up European Network Microbiome Laboratories reach an agreement standardise studies, interactions between researchers access or samples, actively include multiple stakeholders discussions involving assessment. There both short- longer-term priorities, all which highlight need mobilise concurrently different agencies institutions, well research. also points out capacity building training, acceptance emerging technology, communication issues. These will hopefully contribute elaboration widely accepted framework dealing with.

Language: Английский

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