Genes,
Journal Year:
2022,
Volume and Issue:
13(8), P. 1434 - 1434
Published: Aug. 12, 2022
Bacteria
use
quorum
sensing
(QS)
to
communicate
with
each
other
via
secreted
small
autoinducers
produced
by
individuals.
QS
allows
bacteria
display
a
unified
response
that
benefits
the
species
during
adaptation
environment,
colonization,
and
defense
against
competitors.
In
oral
streptococci,
CSP-ComDE
is
an
inducible
DNA
damage
repair
system
pivotal
for
bacterial
survival.
pathogen
Streptococcus
mutans,
positively
influences
formation
of
antibiotic
persisters,
cells
can
survive
attack
entering
non-proliferative
state.
We
recently
identified
novel
gene,
pep299,
activated
in
persister
cell
fraction
induced
QS.
this
study,
we
focused
our
investigation
on
role
gene
encoding
bacteriocin-like
peptide,
persisters.
Mutant
Δ299,
unable
produce
Pep299,
showed
dramatic
reduction
number
stress-induced
Using
co-culture
assay,
overproducing
pep299
persisters
mutant,
suggesting
Pep299
was
actively
detected
neighboring
cells.
Cells
exposed
conditions
expression
pep299.
Interestingly,
results
suggested
also
involved
regulation
QS-inducible
toxin–antitoxin
system.
Our
study
suggests
at
core
triggered
persistence
phenotype
S.
allowing
transition
into
state
reduced
metabolic
activity
tolerance.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: March 16, 2023
A
small
subpopulation
of
Vibrio
splendidus
AJ01
that
was
exposed
to
tetracycline
at
10
times
the
minimal
inhibitory
concentration
(MIC)
still
survived,
named
tetracycline-induced
persister
cells
in
our
previous
work.
However,
formation
mechanisms
is
largely
unknown.
Here,
we
investigated
by
transcriptome
analysis
and
found
purine
metabolism
pathway
significantly
downregulated,
which
consistent
with
lower
levels
ATP,
purine,
derivatives
metabolome
analysis.
Inhibition
6-mercaptopurine
(6-MP,
inhibits
ATP
production),
increased
cell
accompanied
decreasing
intracellular
increasing
protein
aggresome.
On
other
hand,
had
reduced
concentrations
higher
membrane
potential
after
6-MP
treatment.
carbonyl
cyanide
m-chlorophenyl
hydrazone
reversed
6-MP-induced
persistence
resulted
accumulation.
Meanwhile,
treatment
dissipating
transmembrane
proton
pH
gradient,
activated
efflux
decrease
concentration.
Together,
findings
show
reduction
regulates
associated
aggresome
efflux.
Trends in cancer,
Journal Year:
2024,
Volume and Issue:
10(5), P. 393 - 406
Published: March 1, 2024
The
persistence
of
drug-sensitive
tumors
poses
a
significant
challenge
in
cancer
treatment.
concept
bacterial
persisters,
which
are
subpopulation
bacteria
that
survive
lethal
antibiotic
doses,
is
frequently
used
to
compare
residual
disease
cancer.
Here,
we
explore
drug
tolerance
cells
and
bacteria.
We
highlight
the
fact
bacteria,
contrast
cells,
have
been
selected
for
survival
at
population
level
may
therefore
possess
contingency
mechanisms
lack.
precise
drug-tolerant
persisters
still
being
investigated.
Undoubtedly,
by
understanding
common
features
as
well
differences,
we,
field,
can
learn
from
microbiology
find
strategies
eradicate
persisting
cells.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 11883 - 11921
Published: Nov. 1, 2024
Chronic
wound
infection
has
become
a
global
health
problem,
with
bacterial
biofilms,
which
are
difficult
to
penetrate
using
traditional
antibiotics,
considered
the
primary
cause
of
recurrent
and
delayed
healing
in
chronic
wounds.
In
recent
years,
outstanding
performance
nanomaterials
controlling
biofilm
infections
been
widely
acknowledged,
these
materials
regarded
as
highly
promising
for
management.
The
formation
structure
biofilms
undergo
complex
dynamic
changes.
Therefore,
deep
understanding
underlying
causes
repeated
specific
antibacterial
mechanisms
at
different
stages
is
crucial
effective
"chronic
management".
This
review
first
reveals
relationship
between
chronicity,
infections.
Secondly,
it
focuses
on
four
formation:
(1)
adhesion
stage,
(2)
aggregation
promotion
(3)
maturation
(4)
regeneration
dissemination
stage.
It
also
comprehensively
summarizes
nanomaterials.
study
analyzes
essential
factors
affecting
control
by
nanoparticles
from
various
perspectives,
such
material
itself,
local
environment,
systemic
host
response.
Finally,
limitations
potential
future
trends
current
research
discussed.
summary,
represent
strategy
combating
infections,
this
provides
new
insights
alternative
adjuvant
therapies
managing
Genes,
Journal Year:
2022,
Volume and Issue:
13(8), P. 1434 - 1434
Published: Aug. 12, 2022
Bacteria
use
quorum
sensing
(QS)
to
communicate
with
each
other
via
secreted
small
autoinducers
produced
by
individuals.
QS
allows
bacteria
display
a
unified
response
that
benefits
the
species
during
adaptation
environment,
colonization,
and
defense
against
competitors.
In
oral
streptococci,
CSP-ComDE
is
an
inducible
DNA
damage
repair
system
pivotal
for
bacterial
survival.
pathogen
Streptococcus
mutans,
positively
influences
formation
of
antibiotic
persisters,
cells
can
survive
attack
entering
non-proliferative
state.
We
recently
identified
novel
gene,
pep299,
activated
in
persister
cell
fraction
induced
QS.
this
study,
we
focused
our
investigation
on
role
gene
encoding
bacteriocin-like
peptide,
persisters.
Mutant
Δ299,
unable
produce
Pep299,
showed
dramatic
reduction
number
stress-induced
Using
co-culture
assay,
overproducing
pep299
persisters
mutant,
suggesting
Pep299
was
actively
detected
neighboring
cells.
Cells
exposed
conditions
expression
pep299.
Interestingly,
results
suggested
also
involved
regulation
QS-inducible
toxin–antitoxin
system.
Our
study
suggests
at
core
triggered
persistence
phenotype
S.
allowing
transition
into
state
reduced
metabolic
activity
tolerance.
