Hedyotis diffusa alleviate aflatoxin B1-induced liver injury in ducks by mediating Nrf2 signaling pathway DOI Creative Commons
Pengpeng Wang, Yingli Wang, Tianyi Feng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 249, P. 114339 - 114339

Published: Dec. 9, 2022

Aflatoxin B1 (AFB1), the most harmful aflatoxins, is a frequent contamination in feed and food items, raising global concerns animal production human public health. Also, AFB1 induces oxidative stress, cytotoxicity, mutations, DNA lesions through its metabolic transformation into aflatoxin B1–8,9-epoxide (AFBO) by cytochrome P450 (CYP450). Hedyotis diffusa (HD) traditional Chinese herbal medicine known for multiple pharmacological activities, including antioxidant, anti-inflammatory, immunomodulatory. Yet, influence of HD on AFB1-induced liver injury ducks still unknown. Here, we investigated whether positively affects ducks. Results revealed that I) caused significant changes serum biochemical indices decreased growth performance (such as ALT, AST, ALP, TP, ALB, final body weight, weight gain), whereas supplementation at 200 mg/kg mitigated these alterations. II) alleviated hepatic histopathological index induced III) significantly attenuated measured increased antioxidant enzyme activities such SOD, GPx, T-AOC MDA levels. Furthermore, reduced level AFB1-DNA adduct duck liver. IV) promoted transcriptional expression NF-E2-related nuclear factor 2 (Nrf2) associated genes, heme oxygenase 1 (HO-1), NAD(P)H dehydrogenase quinone (NQO1), glutamate-cysteine ligase catalytic (GCLC). In conclusion, results demonstrated could activate Nrf2 pathway to reduce hepatotoxicity driven AFB1. This finding also provides theoretical data support deeper understanding toxic mechanisms prevention.

Language: Английский

Biosynthesis of Nanoparticles Using Plant Extracts and Essential Oils DOI Creative Commons
Sérgio Antunes Filho, Mayara Santana dos Santos, Otávio Augusto L. dos Santos

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(7), P. 3060 - 3060

Published: March 29, 2023

Plant extracts and essential oils have a wide variety of molecules with potential application in different fields such as medicine, the food industry, cosmetics. Furthermore, these plant derivatives are widely interested human animal health, including potent antitumor, antifungal, anti-inflammatory, bactericidal activity. Given this diversity, methodologies were needed to optimize extraction, purification, characterization each class biomolecules. In addition, products can still be used synthesis nanomaterials reduce undesirable effects conventional routes based on hazardous/toxic chemical reagents associate properties those present oils. Vegetable chemically complex, although they already nanomaterials, limited studies examined which effectively acting stabilization nanostructures. Similarly, few investigated whether coating derived from would bring benefits or somehow their This synergistic effect presents promising field further explored. Thus, review article, we conducted comprehensive addressing main groups oils, extraction capacity, available for characterization. Moreover, highlighted metallic antimicrobial capacity. correlated extract’s role activity, considering synergy between product forms associated nanomaterials.

Language: Английский

Citations

67

Unlocking the Potential of Leaf Extracts in Promoting Probiotic Growth DOI
Li Ying Jessie Lau, Kang Huang, Siew Young Quek

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105863 - 105863

Published: Jan. 1, 2025

Language: Английский

Citations

2

Natural Plant Extracts: An Update about Novel Spraying as an Alternative of Chemical Pesticides to Extend the Postharvest Shelf Life of Fruits and Vegetables DOI Creative Commons
Muhammad Umar Shahbaz,

Mehwish Arshad,

Kinza Mukhtar

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(16), P. 5152 - 5152

Published: Aug. 12, 2022

Fresh fruits and vegetables, being the source of important vitamins, minerals, other plant chemicals, are boundless importance these days. Although in agriculture, green revolution was a milestone, it accompanied by intensive utilization chemical pesticides. However, pesticides have hazardous effects on human health environment. Therefore, increasingly stimulating toward more eco-friendly safer alternatives to prevent postharvest losses lead improving shelf life fresh vegetables. Proposed alternatives, natural extracts, very promising due their high efficacy. The plant-based extract is from has no or few concerns. Many researchers elaborated harmful synthetic chemicals life. People now much aware safety concerns than ever before. In present review, we discussed latest research for Considering that use extracts aloe vera, lemongrass, neem non-chemical by-products vegetable industry, they proved safe may be integrated with economic strategies. Such can good alternative preservatives.

Language: Английский

Citations

47

Natural Compounds with Antimicrobial Properties in Cosmetics DOI Creative Commons
Kamila Rybczyńska‐Tkaczyk, Anna Grenda, Anna Jakubczyk

et al.

Pathogens, Journal Year: 2023, Volume and Issue: 12(2), P. 320 - 320

Published: Feb. 15, 2023

Currently, the cosmetic industry is a very intensively growing part of economy. Consumer demands are adapted to current lifestyle, which based on technological innovations and awareness impact various factors human health fitness. There interest in cosmetics environmentally friendly natural compounds exerting health-promoting effects. Chemicals with antimicrobial properties used as ingredients ensure their durability safety. Polyphenolic compounds, peptides, essential oils, plant extracts characterized by these that can replace synthetic components cosmetics. The advantage they exhibit antioxidant, anti-inflammatory, soothing properties, enhancing product value addition properties. This review article describes protect previously preservative agents. Various studies indicate use increases consumer products has positive environment.

Language: Английский

Citations

39

The Most Potent Natural Pharmaceuticals, Cosmetics, and Food Ingredients Isolated from Plants with Deep Eutectic Solvents DOI Creative Commons
Agata Wawoczny, Danuta Gillner

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(29), P. 10877 - 10900

Published: July 11, 2023

There is growing interest in reducing the number of synthetic products or additives and replacing them with natural ones. The pharmaceutical, cosmetic, food industries are especially focused on bioactive chemicals isolated from plants microorganisms. main challenge here to develop efficient ecological methods for their isolation. According strategies rules sustainable development green chemistry, solvents environmentally friendly technologies must be used. application deep eutectic as biodegradable seems a promising alternative traditional methods. They classified being but, most importantly, very extraction media compared organic solvents. aim this review present recent findings extraction, well biological activities possible applications plant ingredients, namely, phenolics, flavonoids, terpenes, saponins, some others. This paper thoroughly reviews modern, ecological, use (DESs). newest findings, factors influencing efficiency such water content, hydrogen bond donor acceptor types, systems, also discussed. New solutions major problem separating DESs extract solvent recycling presented.

Language: Английский

Citations

35

Quorum sensing interference by phenolic compounds – A matter of bacterial misunderstanding DOI Creative Commons
Emília Maria França Lima, Stephen C. Winans, Uelinton Manoel Pinto

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(7), P. e17657 - e17657

Published: June 26, 2023

Over the past decade, numerous publications have emerged in literature focusing on inhibition of quorum sensing (QS) by plant extracts and phenolic compounds. However, there is still a scarcity studies that delve into specific mechanisms which these compounds inhibit QS. Thus, our question whether can QS or indirect manner to elucidate underlying involved. This study focused most studied system, namely, auto-inducer (AI-1) type QS, represented N-acyl-homoserine lactone (AHL) signals AHL-mediated responses. Here, we analyzed recent order understand how act at cellular level, sub-inhibitory concentrations, evaluated they may act. The biotechnological application inhibitors holds promising prospects for pharmaceutical food industries, serving as adjunct therapies prevention biofilms various surfaces.

Language: Английский

Citations

29

Prebiotic property of tamarind seed kernel on Bifidobacterium animalis growth and biofilm formation DOI Creative Commons

Roongrawee Wandee,

Khaetthareeya Sutthanut,

Jenjira Songsri

et al.

Food Chemistry X, Journal Year: 2025, Volume and Issue: 25, P. 102180 - 102180

Published: Jan. 1, 2025

Language: Английский

Citations

1

Insights into antibiofilm mechanisms of phytochemicals: Prospects in the food industry DOI
A.G.M.Sofi Uddin Mahamud, Shamsun Nahar Begum, Md. Ashrafudoulla

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2022, Volume and Issue: 64(6), P. 1736 - 1763

Published: Sept. 6, 2022

The recalcitrance of microbial aggregation or biofilm in the food industry underpins emerging antimicrobial resistance among foodborne pathogens, exacerbating phenomena spoilage, processing and safety management failure, prevalence illnesses. challenges growing tolerance to current chemical disinfectant-based antibiofilm strategies have driven urgency finding a less vulnerable bacterial resistance, effective alternative agent. To address these issues, various novel are suggested days combat biofilm. Among innovative approaches, phytochemicals already demonstrated their excellent performance preventing formation bactericidal actions against resident bacteria within biofilms. However, diverse group different modes action become barrier applying them specific pathogenic biofilm-formers. This phenomenon mandates need elucidate multi-mechanistic design an strategy. Therefore, this review critically illustrates structure - activity relationship, functional sites actions, target molecules regarding multiple major mechanisms reversal resistance. implementation in-depth knowledge will hopefully aid future studies for developing phytochemical-based next-generation antimicrobials.

Language: Английский

Citations

31

Potential application of green extracts rich in phenolics for innovative functional foods: natural deep eutectic solvents as media for isolation of biocompounds from berries DOI Open Access
Mila Lazović, Marko Jović, Marija Petrović

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(8), P. 4122 - 4139

Published: Jan. 1, 2024

The health-promoting effects of berries have attracted attention due to the possible application their extracts as functional ingredients in food products. Natural deep eutectic solvents (NADESs) are a new generation environmentally friendly for extraction natural products, and they green alternatives organic solvents, can improve solubility, stability, bioavailability isolated biocompounds. In this study, an efficient eco-friendly method was used phenolic compounds from different berries: chokeberries, blueberries, black goji with range consisting hydrogen bond acceptors (HBAs) such choline chloride, L-proline, L-glycine, L-lysine donors (HBDs) malic, citric, tartaric, lactic succinic acids, glucose glycerol. obtained results indicated ability NADESs towards selective phenolics; system chloride : malic acid showed anthocyanins, while glycerol urea selectivity flavonoids acids. methodology screening NADES performance, which included chromatographic profiling via high-performance thin layer chromatography combined chemometrics spectrophotometric essays, allowed effective assessment optimal isolation groups phenolics. Great antioxidant antimicrobial activities extracts, along nature enable berry be "green-labelled" foods or ingredients.

Language: Английский

Citations

8

Antimicrobial Effect of Honey Phenolic Compounds against E. coli—An In Vitro Study DOI Creative Commons
Laura Kassym, Assiya Kussainova, Yuliya Semenova

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 560 - 560

Published: April 27, 2024

Growing concern over antimicrobial resistance in chronic wound patients necessitates the exploration of alternative treatments from natural sources. This study suggests that honey’s phenolic compounds may offer benefits, warranting further investigation for therapeutic development. The main aim this was to investigate activity and determine effects their sub-inhibitory concentrations against Escherichia coli (E. coli). 3-phenyllactic acid (PLA), p-coumaric (PCA), phloretin were tested bacterial strain E. ATCC 25922. Comparison honey constituents vitro performed using a broth culture assay. Measurement inhibitory properties conducted disc well diffusion assays. PCA on susceptibility 25922 penicillin–streptomycin tested. results demonstrated PLA most efficient agent, followed by PCA, whereas phloretin, at lower (2 mg/mL) concentrations, led an increase growth coli. Various modifications agar assay did not reveal antibacterial studied phytochemicals. enhancing effect concentration cooperation with shown. These findings might be helpful development new agents treatment skin infections wounds.

Language: Английский

Citations

6