Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
249, P. 114339 - 114339
Published: Dec. 9, 2022
Aflatoxin
B1
(AFB1),
the
most
harmful
aflatoxins,
is
a
frequent
contamination
in
feed
and
food
items,
raising
global
concerns
animal
production
human
public
health.
Also,
AFB1
induces
oxidative
stress,
cytotoxicity,
mutations,
DNA
lesions
through
its
metabolic
transformation
into
aflatoxin
B1–8,9-epoxide
(AFBO)
by
cytochrome
P450
(CYP450).
Hedyotis
diffusa
(HD)
traditional
Chinese
herbal
medicine
known
for
multiple
pharmacological
activities,
including
antioxidant,
anti-inflammatory,
immunomodulatory.
Yet,
influence
of
HD
on
AFB1-induced
liver
injury
ducks
still
unknown.
Here,
we
investigated
whether
positively
affects
ducks.
Results
revealed
that
I)
caused
significant
changes
serum
biochemical
indices
decreased
growth
performance
(such
as
ALT,
AST,
ALP,
TP,
ALB,
final
body
weight,
weight
gain),
whereas
supplementation
at
200
mg/kg
mitigated
these
alterations.
II)
alleviated
hepatic
histopathological
index
induced
III)
significantly
attenuated
measured
increased
antioxidant
enzyme
activities
such
SOD,
GPx,
T-AOC
MDA
levels.
Furthermore,
reduced
level
AFB1-DNA
adduct
duck
liver.
IV)
promoted
transcriptional
expression
NF-E2-related
nuclear
factor
2
(Nrf2)
associated
genes,
heme
oxygenase
1
(HO-1),
NAD(P)H
dehydrogenase
quinone
(NQO1),
glutamate-cysteine
ligase
catalytic
(GCLC).
In
conclusion,
results
demonstrated
could
activate
Nrf2
pathway
to
reduce
hepatotoxicity
driven
AFB1.
This
finding
also
provides
theoretical
data
support
deeper
understanding
toxic
mechanisms
prevention.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(7), P. 3060 - 3060
Published: March 29, 2023
Plant
extracts
and
essential
oils
have
a
wide
variety
of
molecules
with
potential
application
in
different
fields
such
as
medicine,
the
food
industry,
cosmetics.
Furthermore,
these
plant
derivatives
are
widely
interested
human
animal
health,
including
potent
antitumor,
antifungal,
anti-inflammatory,
bactericidal
activity.
Given
this
diversity,
methodologies
were
needed
to
optimize
extraction,
purification,
characterization
each
class
biomolecules.
In
addition,
products
can
still
be
used
synthesis
nanomaterials
reduce
undesirable
effects
conventional
routes
based
on
hazardous/toxic
chemical
reagents
associate
properties
those
present
oils.
Vegetable
chemically
complex,
although
they
already
nanomaterials,
limited
studies
examined
which
effectively
acting
stabilization
nanostructures.
Similarly,
few
investigated
whether
coating
derived
from
would
bring
benefits
or
somehow
their
This
synergistic
effect
presents
promising
field
further
explored.
Thus,
review
article,
we
conducted
comprehensive
addressing
main
groups
oils,
extraction
capacity,
available
for
characterization.
Moreover,
highlighted
metallic
antimicrobial
capacity.
correlated
extract’s
role
activity,
considering
synergy
between
product
forms
associated
nanomaterials.
Molecules,
Journal Year:
2022,
Volume and Issue:
27(16), P. 5152 - 5152
Published: Aug. 12, 2022
Fresh
fruits
and
vegetables,
being
the
source
of
important
vitamins,
minerals,
other
plant
chemicals,
are
boundless
importance
these
days.
Although
in
agriculture,
green
revolution
was
a
milestone,
it
accompanied
by
intensive
utilization
chemical
pesticides.
However,
pesticides
have
hazardous
effects
on
human
health
environment.
Therefore,
increasingly
stimulating
toward
more
eco-friendly
safer
alternatives
to
prevent
postharvest
losses
lead
improving
shelf
life
fresh
vegetables.
Proposed
alternatives,
natural
extracts,
very
promising
due
their
high
efficacy.
The
plant-based
extract
is
from
has
no
or
few
concerns.
Many
researchers
elaborated
harmful
synthetic
chemicals
life.
People
now
much
aware
safety
concerns
than
ever
before.
In
present
review,
we
discussed
latest
research
for
Considering
that
use
extracts
aloe
vera,
lemongrass,
neem
non-chemical
by-products
vegetable
industry,
they
proved
safe
may
be
integrated
with
economic
strategies.
Such
can
good
alternative
preservatives.
Pathogens,
Journal Year:
2023,
Volume and Issue:
12(2), P. 320 - 320
Published: Feb. 15, 2023
Currently,
the
cosmetic
industry
is
a
very
intensively
growing
part
of
economy.
Consumer
demands
are
adapted
to
current
lifestyle,
which
based
on
technological
innovations
and
awareness
impact
various
factors
human
health
fitness.
There
interest
in
cosmetics
environmentally
friendly
natural
compounds
exerting
health-promoting
effects.
Chemicals
with
antimicrobial
properties
used
as
ingredients
ensure
their
durability
safety.
Polyphenolic
compounds,
peptides,
essential
oils,
plant
extracts
characterized
by
these
that
can
replace
synthetic
components
cosmetics.
The
advantage
they
exhibit
antioxidant,
anti-inflammatory,
soothing
properties,
enhancing
product
value
addition
properties.
This
review
article
describes
protect
previously
preservative
agents.
Various
studies
indicate
use
increases
consumer
products
has
positive
environment.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(29), P. 10877 - 10900
Published: July 11, 2023
There
is
growing
interest
in
reducing
the
number
of
synthetic
products
or
additives
and
replacing
them
with
natural
ones.
The
pharmaceutical,
cosmetic,
food
industries
are
especially
focused
on
bioactive
chemicals
isolated
from
plants
microorganisms.
main
challenge
here
to
develop
efficient
ecological
methods
for
their
isolation.
According
strategies
rules
sustainable
development
green
chemistry,
solvents
environmentally
friendly
technologies
must
be
used.
application
deep
eutectic
as
biodegradable
seems
a
promising
alternative
traditional
methods.
They
classified
being
but,
most
importantly,
very
extraction
media
compared
organic
solvents.
aim
this
review
present
recent
findings
extraction,
well
biological
activities
possible
applications
plant
ingredients,
namely,
phenolics,
flavonoids,
terpenes,
saponins,
some
others.
This
paper
thoroughly
reviews
modern,
ecological,
use
(DESs).
newest
findings,
factors
influencing
efficiency
such
water
content,
hydrogen
bond
donor
acceptor
types,
systems,
also
discussed.
New
solutions
major
problem
separating
DESs
extract
solvent
recycling
presented.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(7), P. e17657 - e17657
Published: June 26, 2023
Over
the
past
decade,
numerous
publications
have
emerged
in
literature
focusing
on
inhibition
of
quorum
sensing
(QS)
by
plant
extracts
and
phenolic
compounds.
However,
there
is
still
a
scarcity
studies
that
delve
into
specific
mechanisms
which
these
compounds
inhibit
QS.
Thus,
our
question
whether
can
QS
or
indirect
manner
to
elucidate
underlying
involved.
This
study
focused
most
studied
system,
namely,
auto-inducer
(AI-1)
type
QS,
represented
N-acyl-homoserine
lactone
(AHL)
signals
AHL-mediated
responses.
Here,
we
analyzed
recent
order
understand
how
act
at
cellular
level,
sub-inhibitory
concentrations,
evaluated
they
may
act.
The
biotechnological
application
inhibitors
holds
promising
prospects
for
pharmaceutical
food
industries,
serving
as
adjunct
therapies
prevention
biofilms
various
surfaces.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2022,
Volume and Issue:
64(6), P. 1736 - 1763
Published: Sept. 6, 2022
The
recalcitrance
of
microbial
aggregation
or
biofilm
in
the
food
industry
underpins
emerging
antimicrobial
resistance
among
foodborne
pathogens,
exacerbating
phenomena
spoilage,
processing
and
safety
management
failure,
prevalence
illnesses.
challenges
growing
tolerance
to
current
chemical
disinfectant-based
antibiofilm
strategies
have
driven
urgency
finding
a
less
vulnerable
bacterial
resistance,
effective
alternative
agent.
To
address
these
issues,
various
novel
are
suggested
days
combat
biofilm.
Among
innovative
approaches,
phytochemicals
already
demonstrated
their
excellent
performance
preventing
formation
bactericidal
actions
against
resident
bacteria
within
biofilms.
However,
diverse
group
different
modes
action
become
barrier
applying
them
specific
pathogenic
biofilm-formers.
This
phenomenon
mandates
need
elucidate
multi-mechanistic
design
an
strategy.
Therefore,
this
review
critically
illustrates
structure
-
activity
relationship,
functional
sites
actions,
target
molecules
regarding
multiple
major
mechanisms
reversal
resistance.
implementation
in-depth
knowledge
will
hopefully
aid
future
studies
for
developing
phytochemical-based
next-generation
antimicrobials.
Food & Function,
Journal Year:
2024,
Volume and Issue:
15(8), P. 4122 - 4139
Published: Jan. 1, 2024
The
health-promoting
effects
of
berries
have
attracted
attention
due
to
the
possible
application
their
extracts
as
functional
ingredients
in
food
products.
Natural
deep
eutectic
solvents
(NADESs)
are
a
new
generation
environmentally
friendly
for
extraction
natural
products,
and
they
green
alternatives
organic
solvents,
can
improve
solubility,
stability,
bioavailability
isolated
biocompounds.
In
this
study,
an
efficient
eco-friendly
method
was
used
phenolic
compounds
from
different
berries:
chokeberries,
blueberries,
black
goji
with
range
consisting
hydrogen
bond
acceptors
(HBAs)
such
choline
chloride,
L-proline,
L-glycine,
L-lysine
donors
(HBDs)
malic,
citric,
tartaric,
lactic
succinic
acids,
glucose
glycerol.
obtained
results
indicated
ability
NADESs
towards
selective
phenolics;
system
chloride
:
malic
acid
showed
anthocyanins,
while
glycerol
urea
selectivity
flavonoids
acids.
methodology
screening
NADES
performance,
which
included
chromatographic
profiling
via
high-performance
thin
layer
chromatography
combined
chemometrics
spectrophotometric
essays,
allowed
effective
assessment
optimal
isolation
groups
phenolics.
Great
antioxidant
antimicrobial
activities
extracts,
along
nature
enable
berry
be
"green-labelled"
foods
or
ingredients.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(5), P. 560 - 560
Published: April 27, 2024
Growing
concern
over
antimicrobial
resistance
in
chronic
wound
patients
necessitates
the
exploration
of
alternative
treatments
from
natural
sources.
This
study
suggests
that
honey’s
phenolic
compounds
may
offer
benefits,
warranting
further
investigation
for
therapeutic
development.
The
main
aim
this
was
to
investigate
activity
and
determine
effects
their
sub-inhibitory
concentrations
against
Escherichia
coli
(E.
coli).
3-phenyllactic
acid
(PLA),
p-coumaric
(PCA),
phloretin
were
tested
bacterial
strain
E.
ATCC
25922.
Comparison
honey
constituents
vitro
performed
using
a
broth
culture
assay.
Measurement
inhibitory
properties
conducted
disc
well
diffusion
assays.
PCA
on
susceptibility
25922
penicillin–streptomycin
tested.
results
demonstrated
PLA
most
efficient
agent,
followed
by
PCA,
whereas
phloretin,
at
lower
(2
mg/mL)
concentrations,
led
an
increase
growth
coli.
Various
modifications
agar
assay
did
not
reveal
antibacterial
studied
phytochemicals.
enhancing
effect
concentration
cooperation
with
shown.
These
findings
might
be
helpful
development
new
agents
treatment
skin
infections
wounds.