Gallnut Tannic Acid Exerts Anti-stress Effects on Stress-Induced Inflammatory Response, Dysbiotic Gut Microbiota, and Alterations of Serum Metabolic Profile in Beagle Dogs DOI Creative Commons
Kang Yang,

Shiyan Jian,

Chaoyu Wen

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: April 27, 2022

Stress exposure is a potential threat to humans who live or work in extreme environments, often leading oxidative stress, inflammatory response, intestinal dysbiosis, and metabolic disorders. Gallnut tannic acid (TA), naturally occurring polyphenolic compound, has become compelling source due its favorable anti-diarrheal, anti-oxidative, anti-inflammatory, anti-microbial activities. Thus, this study aimed evaluate the anti-stress effects of gallnut TA on stress-induced dysbiotic gut microbiota, alterations serum profile using beagle models. A total 13 dogs were randomly divided into stress (ST) ST + groups. Dietary supplementation with at 2.5 g/kg was individually fed each dog group for 14 consecutive days. On day 7, all transported 3 h from stressful environment (days 1-7) livable site 8-14). In our results, relieved environmental diarrheal symptoms shown protect myocardial injury help improve immunity by biochemistry hematology analysis. Also, inhibited secretion hormones [cortisol (COR), glucocorticoid (GC), adrenocorticotropic hormone (ACTH)] expression heat shock protein (HSP) 70 injury, thereby relieving response. Fecal 16S rRNA gene sequencing revealed that stimulated growth beneficial bacteria (Allobaculum, Dubosiella, Coriobacteriaceae_UCG-002, Faecalibaculum) suppressed pathogenic (Escherichia-Shigella Streptococcus), increasing fecal butyrate levels. Serum metabolomics further showed phytosphingosine, indoleacetic acid, arachidonic biotin, related metabolism sphingolipid, tryptophan, respectively, could serve as biomarkers exposure. Furthermore, Spearman's correlation analysis strong relationships between four differential bacteria. Overall, may be prebiotic prevention treatment disorders targeting microbiota.

Language: Английский

Biochemistry of Antioxidants: Mechanisms and Pharmaceutical Applications DOI Creative Commons
Sonia Losada‐Barreiro, Zerrin Sezgin Bayındır, Fátima Paiva‐Martins

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3051 - 3051

Published: Nov. 25, 2022

Natural antioxidants from fruits and vegetables, meats, eggs fish protect cells the damage caused by free radicals. They are widely used to reduce food loss waste, minimizing lipid oxidation, as well for their effects on health through pharmaceutical preparations. In fact, use of natural is among main efforts made relieve pressure resources move towards more sustainable systems. Alternative waste management approaches include valorization by-products a source phenolic compounds functional formulations. this review, we will deal with chemistry antioxidants, including molecular structures reaction mechanisms. The biochemical aspects also be reviewed, acidity temperature partitioning in binary multiphasic poor bioavailability remains huge constraint clinical applications, briefly describe some delivery systems that provide enhanced pharmacological action via drug targeting increased bioavailability. activity can improved designing nanotechnology-based formulations, recent nanoformulations nanoparticles, polymeric micelles, liposomes/proliposomes, phytosomes solid all showing promising outcomes improving efficiency antioxidants. Finally, an overview effects, therapeutic properties future choice incorporated.

Language: Английский

Citations

83
ROS-triggered self-disintegrating and pH-responsive astaxanthin nanoparticles for regulating the intestinal barrier and colitis DOI
Xuedi Zhang, Xue Zhao,

Zheng Hua

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 292, P. 121937 - 121937

Published: Nov. 30, 2022

Language: Английский

Citations

70
Marine algae: A treasure trove of bioactive anti-inflammatory compounds DOI

Dina S. Ghallab,

Reham S. Ibrahim, Mohamed M. Mohyeldin

et al.

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 199, P. 116023 - 116023

Published: Jan. 10, 2024

Language: Английский

Citations

25
Sophora japonica flowers and their main phytochemical, rutin, regulate chemically induced murine colitis in association with targeting the NF-κB signaling pathway and gut microbiota DOI
Yan Liu,

Weisu Huang,

Shengyang Ji

et al.

Food Chemistry, Journal Year: 2022, Volume and Issue: 393, P. 133395 - 133395

Published: June 4, 2022

Language: Английский

Citations

52
Extracellular vesicle miRNAs promote the intestinal microenvironment by interacting with microbes in colitis DOI Creative Commons
Qichen Shen,

Zhuizui Huang,

Lingyan Ma

et al.

Gut Microbes, Journal Year: 2022, Volume and Issue: 14(1)

Published: Sept. 29, 2022

Inflammatory bowel disease (IBD) is a global with no cure. Disruption of the microbial ecosystem considered to be an important cause IBD. Extracellular vesicles (EVs) are vital participants in cell–cell and cell-organism communication. Both host-derived EVs bacteria-derived membrane (OMVs) contribute homeostasis intestine. However, roles EVs-miRNAs MVs host-microbe interactions colitis remain unclear. In present study, animal model was established by dextran sulfate sodium (DSS) investigate changes miRNAs colonic from colitis. Several were significantly altered EVs. miR-181b-5p transplantation inhibited M1 macrophage polarization promoted M2 reduce levels inflammation both acute remission chronic miR-200b-3p could interact bacteria regulate composition microbiota, which contributed intestinal barrier integrity homeostasis. Notably, normal feces effectively reverse restore rescue colitis, BMVs would also have similar effects after treatment. Our results preliminarily identify vesicle-based host‐microbe interaction cycle provide new ideas for

Language: Английский

Citations

40
A comprehensive review of the classification, sources, biosynthesis, and biological properties of hydroxybenzoic and hydroxycinnamic acids DOI
Aline Priscilla Gomes da Silva, William Gustavo Sganzerla, Oliver D. John

et al.

Phytochemistry Reviews, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 17, 2023

Language: Английский

Citations

30
Gut Bacterial Indole-3-acetic Acid Induced Immune Promotion Mediates Preventive Effects of Fu Brick Tea Polyphenols on Experimental Colitis DOI
Xiangnan Zhang, Lin Shi, Nan Wang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(2), P. 1201 - 1213

Published: Jan. 9, 2023

Ulcerative colitis has been consistently associated with gut microbiota imbalance and disturbed immune system. Emerging research suggests a protective function of polyphenols on prevention treatment ulcerative colitis, yet underlying mechanisms remain unclear. Fu brick tea, postfermented contains abundant anti-inflammatory antioxidant properties. In the present study, we found that prophylactic supplementation extracted from tea (FBTP) dose-dependently alleviated symptoms, cells infiltration, pro-inflammatory cytokines secretion in mice suffering dextran sulfate sodium induced murine colitis. FBTP substantially reshaped promoted microbial transformation tryptophan into indole-3-acetic acid (I3A), thereafter leading to aryl hydrocarbon receptor (AHR)-mediated protection through enhanced expressions IL-22 tight junction proteins (i.e., ZO-1, occluding claudin-1) colon. Multiomics integration analyses revealed strong connections between I3A, tryptophan-metabolizing bacteria, AHR activity, pathological phenotypes Notably, failed significantly alleviate symptoms absence microbiota, while intragastric administration I3A could imitate benefits alleviation intestinal epithelial homeostasis direct enhancement activity microbiota-depleted mice. These findings further determine key role controlled I3A-AHR signaling mediating alleviation. This study provides first data proposing as natural prebiotic for microbiota-dependent modulation pathway. Most importantly, also identified metabolite targeted by exhibiting health-promoting effects.

Language: Английский

Citations

25
Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets DOI Creative Commons
Xiaobin Wen, Fan Wan, You Wu

et al.

Food & Function, Journal Year: 2023, Volume and Issue: 14(16), P. 7705 - 7717

Published: Jan. 1, 2023

CA supplementation could enhance intestinal integrity and barrier function by modifying microbiota its metabolites, which lead to a reduction in inflammatory responses oxidative stress LPS-challenged piglets.

Language: Английский

Citations

25
Gut microbiota-derived metabolites in inflammatory diseases based on targeted metabolomics DOI Creative Commons
Hui Xu,

Li-Bin Pan,

Hang Yu

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 27, 2022

The gut microbiota plays an important role in inflammatory diseases. Metabolites the three metabolic pathways of tryptophan (Trp), histidine (His), and phenylalanine (Phe) can affect various conditions, such as obesity, diabetes, arthritis, colitis, atherosclerosis, neuroinflammation. We established LC-MS/MS method to measure 17 metabolites-Trp, 3-indole-acetic acid (Iaa), 3-indole-lactate (Ila), 3-indole-propionic (Ipa), 3-indole formaldehyde (Iald), kynurenine (Kn), kynurenic (Kyna), 3-Hydroxyanthranilic (3-Haa), His, 3-methylhistidine (3-Mhis), histamine (Hist), imidazole propionic (Imp), 4-imidazoacetic (Imaa), urocanic (Ua), Phe, phenylethylamine (Pea), hippuric (Ha)-in pathways. exhibited high sensitivity good selectivity, linearity, accuracy, precision, stability; recovery rate; all met requirements biological sample analysis. By establishing a rheumatoid arthritis (RA) model Sprague-Dawley rats performing 16S rRNA sequencing on their feces, it was found that there dysbiosis, including changes phylum level, genus α biodiversity bacteria. contents metabolites Iaa Ipa group were significantly decreased, those Iald, Kn, Kyna, Ha, Imp increased. common therapeutic drugs Tripterygium glycosides, total glucosides peony, main active ingredients screened by vitro incubation with bacteria: glycosides could lead variation Trp Phe Total components peony pathway microbiota.

Language: Английский

Citations

30
Coffee by-products: An underexplored source of prebiotic ingredients DOI Creative Commons
Marlene Machado, Helena Ferreira, M. Beatriz P.P. Oliveira

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(20), P. 7181 - 7200

Published: Feb. 27, 2023

Consumers' demand for foods with high nutritional value and health benefits has fueled the development of prebiotic foods. In coffee industry, cherries transformation into roasted beans generates a large amount waste/by-products (pulp/husks, mucilage, parchment, defective beans, silverskin spent grounds) that usually end up in landfills. The possibility to use by-products as relevant sources ingredients is herein ascertained. As prelude this discussion, an overview pertinent literature on action was conducted, including biotransformation prebiotics, gut microbiota, metabolites. Existing research indicates contain significant levels dietary fiber other components can improve by stimulating beneficial bacteria colon, making them excellent candidates ingredients. Oligosaccharides from have lower digestibility than inulin be fermented microbiota functional metabolites, such short-chain fatty acids. Depending concentration, melanoidins chlorogenic acids may also action. Nevertheless, there still lack vivo studies validate findings vitro. This review shows how interesting foods, contributing sustainability, circular economy, food security, health.

Language: Английский

Citations

22